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| 1 | Inflammation and retinal degenerative diseases显示文摘Vision is an ability that depends on the precise structure and functioning of the retina.Any kind of stress or injury can disrupt the retinal architecture and leads to vision impairment,vision loss,and blindness.Immune system and immune response function maintain homeostasis in the microenvironment.Several genetic,metabolic,and environmental factors may alter retinal homeostasis,and these events may initiate various inflammatory cascades.The prolonged inflammatory state may contribute to the initiation and development of retinal disorders such as glaucoma,age-related macular degeneration,diabetic retinopathy,and retinitis pigmentosa,which pose a threat to vision.In the current review,we attempted to provide sufficient evidence on the role of inflammation in these retinal disorders.Moreover,this review paves the way to focus on therapeutic targets of the disease,which are found to be promising. | Geetika Kaur Nikhlesh K.Singh | 2023 | Neural Regeneration Research2023，18，3： | 3 |
| 2 | The Transcription Factor CREB Enhances Interleukin-17A Production and Inflammation in a Mouse Model of Atherosclerosis显示文摘 | Sivareddy Kotla Nikhlesh K. Singh Mark R. Heckle Gabor J. Tigyi Gadiparthi N. Rao | 2013 | 2013 (293)2013，，293： | 1 |
| 3 | Nanotechnology for colorectal cancer detection and treatment显示文摘Colorectal cancer(CRC)is the third most diagnosed cancer and the second leading cause of cancer-related mortality in the United States.Across the globe,people in the age group older than 50 are at a higher risk of CRC.Genetic and environmental risk factors play a significant role in the development of CRC.If detected early,CRC is preventable and treatable.Currently,available screening methods and therapies for CRC treatment reduce the incidence rate among the population,but the micrometastasis of cancer may lead to recurrence.Therefore,the challenge is to develop an alternative therapy to overcome this complication.Nanotechnology plays a vital role in cancer treatment and offers targeted chemotherapies directly and selectively to cancer cells,with enhanced therapeutic efficacy.Additionally,nanotechnology elevates the chances of patient survival in comparison to traditional chemotherapies.The potential of nanoparticles includes that they may be used simultaneously for diagnosis and treatment.These exciting properties of nanoparticles have enticed researchers worldwide to unveil their use in early CRC detection and as effective treatment.This review discusses contemporary methods of CRC screening and therapies for CRC treatment,while the primary focus is on the theranostic approach of nanotechnology in CRC treatment and its prospects.In addition,this review aims to provide knowledge on the advancement of nanotechnology in CRC and as a starting point for researchers to think about new therapeutic approaches using nanotechnology. | Purnima Gogoi Geetika Kaur Nikhlesh K Singh | 2022 | World Journal of Gastroenterology2022，28，46： | 0 |
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