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| 1 | Liver cystic echinococcosis and human host immune and autoimmune follow-up:A review显示文摘Cystic echinococcosis(CE) is an infectious disease caused by the larvae of parasite Echinococcus granulosus(E.granulosus).To successfully establish an infection,parasite release some substances and molecules that can modulate host immune functions,stimulating a strong anti-inflammatory reaction to carry favor to host and to reserve self-survival in the host.The literature was reviewed using MEDLINE,and an open access search for immunology of hydatidosis was performed.Accumulating data from animal experiments and human studies provided us with exciting insights into the mechanisms involved that affect all parts of immunity.In this review we used the existing scientific data and discuss how these findings assisted with a better understanding of the immunology of E.granulosus infection in man.The aim of this study is to point the several facts that challenge immune and autoimmune responses to protect E.granulosus from elimination and to minimize host severe pathology.Understanding the immune mechanisms of E.granulosus infection in an intermediate human host will provide,we believe,a more useful treatment with immunomodulating molecules and possibly better protection from parasitic infections.Besides that,the diagnosis of CE has improved due to the application of a new molecular tool for parasite identification by using of new recombinant antigens and immunogenic peptides.More studies for the better understanding of the mechanisms of parasite immune evasion is necessary.It will enable a novel approach in protection,detection and improving of the host inflammatory responses.In contrast,according to the 'hygiene hypothesis',clinical applications that decrease the incidence of infection in developed countries and recently in developing countries are at the origin of the increasing incidence of both allergicand autoimmune diseases.Thus,an understanding of the immune mechanisms of E.granulosus infection is extremely important. | Nikica M Grubor Katica D Jovanova-Nesic Yehuda Shoenfeld | 2017 | World Journal of Hepatology2017，9，30： | 8 |
| 2 | Cystic lymphangioma of the pancreas显示文摘Lymphangioma of the pancreas is an extremely rare benign tumour of lymphatic origin,with fewer than 60 published cases. Histologically,it is polycystic,with the cysts separated by thin septa and lined with endothelial cells. Though congenital,it can affect all age groups,and occurs more frequently in females. Patients usually present with epigastric pain and an associated palpable mass. Complete excision is curative,even though,depending on the tumour location,surgery may be simple or involve extensive pancreatic resection and anastomoses. The authors present a 49-year-old woman in whom a polycystic septated mass,35 mm x 35 mm in size,was discovered by ultrasonography (US) in the body of the pancreas during investigations for epigastric pain and nausea. At surgery,a well circumscribed polycystic tumor was completely excised,with preservation of the pancreatic duct. The postoperative recovery was uneventful. Histology confirmed a microcystic lymphangioma of the pancreas. Immunohistochemistry showed cystic endothelial cells reactivity to factor Ⅷ -RA (++),CD31 (+++) and CD34 (-). Postoperatively,abdominal pain disappeared and the patient remained symptomfree for 12 mo until now. Although extremely rare,lymphangioma of the pancreas should be taken into consideration as a differential diagnosis of a pancreatic cystic lesion,especially in women. | Radoje B Colovic Nikica M Grubor Marjan T Micev Henry Dushan E Atkinson Vitomir I Rankovic Mihajlo M Jagodic | 2008 | World Journal of Gastroenterology2008，14，44： | 6 |
| 3 | Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME显示文摘AIM To cure typically life-threatening esophagogastric anastomosis in rats, lacking anastomosis healing and sphincter function rescue, in particular. METHODS Because we assume esophagogastric fistulas represent a particular NO-system disability, we attempt to identify the benefits of anti-ulcer stable gastric pentadecapeptide BPC 157, which was in trials for ulcerative colitis and currently for multiple sclerosis, in rats with esophagocutaneous fistulas. Previously, BPC 157 therapies have promoted the healing of intestinal anastomosis and fistulas, and esophagitis and gastric lesions, along with rescued sphincter function. Additionally, BPC 157 particularly interacts with the NOsystem. In the 4 d after esophagogastric anastomosis creation, rats received medication(/kg intraperitoneallyonce daily: BPC 157(10 μg, 10 ng), L-NAME(5 mg), or L-arginine(100 mg) alone and/or combined or BPC 157(10 μg, 10 ng) in drinking water). For rats underwent esophagogastric anastomosis, daily assessment included progressive stomach damage(sum of the longest diameters, mm), esophagitis(scored 0-5), weak anastomosis(m L H2 O before leak), low pressure in esophagus at anastomosis and in the pyloric sphincter(cm H2O), progressive weight loss(g) and mortality. Immediate effect assessed blood vessels disappearance(scored 0-5) at the stomach surface immediately after anastomosis creation. RESULTS BPC 157(all regimens) fully counteracted the perilous disease course from the very beginning(i.e., with the BPC 157 bath, blood vessels remained present at the gastric surface after anastomosis creation) and eliminated mortality. Additionally, BPC 157 treatment in combination with L-NAME nullified any effect of L-NAME that otherwise intensified the regular course. Consistently, with worsening(with L-NAME administration) and amelioration(with L-arginine), either L-arginine amelioration prevails(attenuated esophageal and gastric lesions) or they counteract each other(L-NAME + L-arginine); with the addition of BPC 157(L-NAME + L-arginine + BPC 157), there was a marked beneficial effect. BPC 157 treatment for esophagogastric anastomosis, along with NOS-blocker L-NAME and/or NOS substrate L-arginine, demonstrated an innate NO-system disability(as observed with L-arginine effectiveness). BPC 157 distinctively affected corresponding events: worsening(obtained with L-NAME administration that was counteracted); or amelioration(L-arginine + BPC 157-rats correspond to BPC 157-rats).CONCLUSION Innate NO-system disability for esophagogastric anastomoses, including L-NAME-worsening, suggests that these effects could be corrected by L-arginine and almost completely eliminated by BPC 157 therapy. | Zeljko Djakovic Ivka Djakovic Vedran Cesarec Goran Madzarac Tomislav Becejac Goran Zukanovic Domagoj Drmic Lovorka Batelja Anita Zenko Sever Danijela Kolenc Alen Pajtak Nikica Knez Mladen Japjec Kresimir Luetic Dinko Stancic-Rokotov Sven Seiwerth Predrag Sikiric | 2016 | World Journal of Gastroenterology2016，22，41： | 3 |
| 4 | Perigastric extraskeletal Ewing's sarcoma: A case report显示文摘Ewing's sarcoma (ES) is a neoplasm of undifferentiated small round cells, which occurs in the bones and deep soft tissues of children and adolescents. We present a rare case of a 44-year-old woman with gastric ES presenting with epigastric pain and weight loss. Ultrasound and computed tomography scans indicated a solid/cystic mass in the pancreatic tail. At laparotomy, the tumor was found attached to the posterior surface of the stomach, completely free from the pancreas, with no lymphadenopathy or local metastases. The polynodal, partly pseudocystic, dark-red soft tumor was excised. Histopathology revealed an anaplastic small-round-cell tumor with strong membranous CD99 immunoexpression. Additionally, there was patchy immunostaining for S-100 protein, vimentin, protein gene product (PGP) 9.5 and neuron-specifi c enolase, and weak focal CD117 cytoplasmic immunoreactivity. The patient had no adjuvant chemotherapy; her postoperative recovery was uneventful, and she remains symptom-free, and without any sign of recurrence at 20 mo. To the best of our knowledge, this is only the third ever case of gastric ES. | Radoje B Colovic Nikica M Grubor Marjan T Micev Slavko V Matic Henry Dushan Edward Atkinson Stojan M Latincic | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 5 | Two synchronous somatostatinomas of the duodenum and pancreatic head in one patient显示文摘Somatostatinomas are extremely rare neuroendocrine tumors of the gastrointestinal tract,f irst described in the pancreas in 1977 and in the duodenum in 1979.They may be functional and cause somatostatinoma or inhibi-tory syndrome,but more frequently are non-functioning pancreatic endocrine tumors that produce somatostatin alone.They are usually single,malignant,large lesions,frequently associated with metastases,and generally with poor prognosis.We present the unique case of a 57-year-old woman with two synchronous non-function-ing somatostatinomas,one solid duodenal lesion and one cystic lesion within the head of the pancreas,that were successfully resected with a pylorus-preserving Whipple's procedure.No secondaries were found in the liver,or in any of the removed regional lymph nodes.The patient had an uneventful recovery,and remains well and symptom-free at 18 mo postoperatively.This is an extremely rare case of a patient with two synchro-nous somatostatinomas of the duodenum and the pancreas.The condition is discussed with reference to the literature. | Radoje B olovi Slavko V Mati Marjan T Micev Nikica M Grubor Henry Dushan Atkinson Stojan M Latini | 2009 | World Journal of Gastroenterology2009，15，46： | 1 |
| 6 | Abdominal neurenteric cyst显示文摘Neurenteric cysts are extremely rare congenital anomalies,often presenting in the first 5 years of life,and are caused by an incomplete separation of the notochord from the foregut during the third week of embryogenesis. They are frequently accompanied with spinal or gastrointestinal abnormalities,but the latter may be absent in adults. Although usually located in the thorax,neurenteric cysts may be found along the entire spine. We present a 24-year-old woman admitted for epigastric pain,nausea,vomiting,low grade fever and leucocytosis. She underwent cystgastrostomy for a loculated cyst of the distal pancreas at the age of 4 years,which recurred when she was at the age of 11 years. Ultrasound and computer tomograghy(CT) scan revealed a 16 cm × 15 cm cystic mass in the body and tail of pancreas,with a 6-7 mm thickened wall. Laboratory data and chest X-ray were normal and spinal radiographs did not show any structural abnormalities. The patient underwent a complete cyst excision,and after an uneventful recovery,remained symptom-free without recurrence during the 5-year follow-up. The cyst was found to contain 1200 mL of pale viscous fluid. It was covered by a primitive single-layered cuboidal epithelium,along with specialized antral glandular parenchyma and hypoplastic primitive gastric mucosa. Focal glandular groups resemblingthose of the body of the stomach were also seen. In addition,ciliary respiratory epithelium,foci of squamous metaplasia and mucinous glands were present. The wall of the cyst contained a muscular layer,neuroglial tissue with plexogenic nerve fascicles,Paccini corpuscle-like structures,hyperplastic neuroganglionar elements and occasional psammomatous bodies,as well as fibroblast-like areas of surrounding stroma. Cartilagenous tissue was not found in any part of the cyst. Immunohistochemistry confirmed the presence of neurogenic elements marked by S-100,GFAP,NF and NSE. The gastric epithelium showed mostly CK7 and EMA immunoexpression,and the respiratory epithelium revealed a CK8 and CK18 immunoprofile without CK 10/13 positive elements,though neither CEA or AFP positive cells were found. To our knowledge,this is the first reported case of an abdominally located neurenteric cyst with no associated spinal anomalies. | Radoje olovi Marjan Micev Miodrag Jovanovi Slavko Mati Nikica Grubor Henry Dushan E Atkinson | 2008 | World Journal of Gastroenterology2008，14，23： | 1 |
| 7 | An experimental investigation of rate-dependent deformation and failure of three titanium alloys显示文摘 | Helen Sarsfield Li Wang Nikica Petrinic | 2007 | Journal of Materials Science2007，，13： | 1 |
| 8 | Complications following two methods of posterior chamber intraocular lens suturing显示文摘 | Nikica Gabri? Ljerka Hen?-Petrinovi? Iva Dekaris | 1996 | Documenta Ophthalmologica1996，，2： | 1 |
| 9 | Metastatic melanoma to the common bile duct causing obstructive jaundice:A case report显示文摘Metastatic melanoma to the common bile duct is very rare with only 18 cases reported so far. We report a 46 year old women who, 18 mo after excision of a skin melanoma, developped a painless progressive obstructive jaundice. At operation a melanoma within the distal third of the common bile duct was found. There were no other secondaries within the abdomen. The common bile duct, including the tumor, was resected and anastomosed with Roux-en-Y jejunal limb. The patient survived 31 mo without any sign of local recurrence and was submitted to three other operations for axillar and brain secondaries, from which she finally died. Radical resection of metastatic melanoma to the common bile duct may result in lifelong relief of obstructive jaundice. It is safe and relatively easy to perform. In other cases, a less aggressive approach, stenting or bypass procedures, should be adopted. | Radoje B Colovic Nikica M Grubor Miodrag D Jovanovic Marjan T Micev Natasa R Colovic | 2007 | World Journal of Gastroenterology2007，13，5： | 1 |
| 10 | Efficacy of IP6+ inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical study 显示文摘 | IVAN B NIKICA D ROBERT K | 2010 | J Exp Clin Cancer Res2010，29，1： | 1 |
| 11 | Formation of nanocrystalline silicon carbide powder from chlorine-containing polycarbosilane precursors 显示文摘 | Mitchell Brian S Zheng Haoyue Nikica Maljkoric | 1999 | J Am Ceram Soc1999，82，8： | 1 |
| 12 | Intravitreally administered bevacizumab (Avastin) in minimally classic and occult choroidal neovascularization secondary to age-related macular degeneration显示文摘 | Ratimir Lazic Nikica Gabric | 2007 | Graefe’s Archive for Clinical and Experimental Ophthalmology2007，，1： | 1 |
| 13 | Tuberculous lymphadenitis as a cause of obstructive jaundice:A case report and literature review显示文摘Obstructive jaundice secondary to tuberculosis (TB) is extremely rare. It can be caused by TB enlargement of the head of the pancreas, TB lymphadenitis, TB stricture of the biliary tree, or a TB mass of the retroperitoneum. A 29-year-old man with no previous history of TB presented with abdominal pain, obstructive jaundice, malaise and weight loss. Ultrasonography (US), computer tomography (CT) scan and endoscopic retrograde cholangiopancreatography (ERCP) were suggestive of a stenosis of the distal common bile duct (CBD) caused by a mass in the posterior head of the pancreas. Tumor markers, CEA and CA19-9 were within normal limits. At operation, an enlarged, centrally caseous lymph node of the posterior head of the pancreas was found, causing inflammatory stenosis and a fistula with the distal CBD. The lymph node was removed and the bile duct resected and anastomosed with the Roux-en Y jejunal limb. Histology and PCR based-assay confirmed tuberculous lymphadenitis. After an uneventful postoperative recovery, the patient was treated with anti-tuberculous medication and remained well 2.5 years later. Though obstructive jaundice secondary to tuberculous lymphadenitis is rare, abdominal TB should be considered as a differential diagnosis in immunocompromised patients and in TB endemic areas. Any stenosis or fistulation into the CBD should also be taken into consideration, and biliary bypass surgery be performed to both relieve jaundice and prevent further stricture. | Radoje Colovic Nikica Grubor Rada Jesic Marjan Micev Tanja Jovanovic Natasa Colovic Henry Dushan Atkinson | 2008 | World Journal of Gastroenterology2008，14，19： | 1 |
| 14 | Flooding as a cause of ungulate mortality in floodplain forests in Croatia显示文摘Floodplain forests with regular flooding regimes are the largest natural retentions areas in Croatia and are important as natural habitats for ungulates.The aim of this study was to determine the scale of mortality caused by flooding within these forests.Over a 10-year period,data on ungulate mortality(red deer,roe deer and wild boar),flood duration and flooded surface area were recorded.The study was conducted in primary(Posavske Sume—RET I)and secondary(Opeke II—RET II)retention areas within Lonjsko Polje Nature Park(Sava River region,Croatia).The longest flood period and the largest flooded surface area were recorded in RET I.Total ungulate mortality was749 individuals,with 482 individuals in RET I and 267 individuals in RET II,predominantly wild boar.Flood mortality did not differ by gender.The highest mortality of wild boar was recorded for the juvenile and yearling ageclasses.Low mortality of red and roe deer can be attributed to their body size and ecological niches.Differences in mortality between the primary and secondary retention areas corresponded to differences in flood regimes,flood column heights and micro relief structures.In both retention areas,wild boar mortality and flood duration,i.e.flooded surface area,were positively correlated.Because the growth rate of the analysed ungulate populations was higher than the recorded mortality,no long-term effect of floods is expected on species abundance in these areas. | Damir Ugarkovic Nikica Sprem Nikolina Kelava Ugarkovic Milan Orsanic | 2020 | Journal of Forestry Research2020，31，3： | 0 |
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