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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 3 | Modulation of T lymphocyte function by neuropeptides 显示文摘 | Nio D A Moylan R N Roche J K | 1993 | J lmmunol1993，150，： | 1 |
| 4 | E-cadherin,Alpha-catenin and Beta-catenin in Biliary Atresia:Correlation with Apoptosis And Cell Cycle显示文摘 | SASAKI H NIO M IWAMI D | 2001 | Pathol Int2001，51，12： | 1 |
| 5 | Efficiency of manual versus robotical (Zeus) assisted laparoscopic surgery in the performance of standardized tasks显示文摘 | Nio D Bemelman WA Boer KT | 2002 | Surg Endosc2002，16，3： | 1 |
| 6 | Plasmodium vivax infection among Duffy antigen-negative individuals from the Brazilian Amazon region: an exception?显示文摘 | Carlos Eugênio Cavasini Luiz Carlos de Mattos álvaro Augusto D'Almeida Couto Cláudia Regina Bonini-Domingos Socrates Herrera Valencia Wanessa Christina de Souza Neiras Renata Tomé Alves Andréa Regina Baptista Rossit Lilian Castilho Ricardo Luiz Dantas Mac | 2007 | Transactions of the Royal Society of Tropical Medicine and Hygiene2007，，10： | 1 |
| 7 | Laparoscop ic vascular surgery:a system review显示文摘 | Nio D Diks J Bemelman WA | 2007 | Eur J Vas Endovasc Surg2007，33，3： | 1 |
| 8 | E - cadherin, alpha - catenin and beta -catenin in biliary atresia: correlaltion with apoptosis and cell cycle 显示文摘 | Sasaki H Nio M Iwami D | 2001 | Pathol Int2001，51，12： | 1 |
| 9 | Endoscopic versus sur- gical drainage of the pancreatic duct in chronic pancreatitis 显示文摘 | Cahen DL Gouma D J Nio Y | 2007 | N Engl J Med2007，356，7： | 1 |
| 10 | E-cadherin,Alpha-catenin and Beta-catenin in Biliary Atresia:Correlation with Apoptosis and Cell Cycle显示文摘 | SASSKI H NIO M LWAMI D | 2001 | Pathol Int2001，51，12： | 1 |
| 11 | Lapamscopic vascular surgery : a system review 显示文摘 | Nio D Diks J Bemelman WA | 2007 | Eur J Vas Endovasc Surg2007，33，3： | 1 |
| 12 | Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis显示文摘 | Cahen DL Gouma D J Nio Y | 2007 | N Engl J Med2007，356，15： | 1 |
| 13 | Man- agement of splenic abscess in immuno- compromised children显示文摘 | Smith M D Nio M Camel J E et aI | 1993 | J Pediatr Surg1993，28，6： | 1 |
| 14 | Sound insulation provided by single and double panel walls-a comparison of analytical solutions versus experimental resuhs显示文摘 | A Tadeu J Ant 6 nio D Mateus | 2004 | Applied Acoustics2004，65，1： | 1 |
| 15 | Robot-assisted laparoscopic surgery of the infrarenal aorta:the early learning curve显示文摘 | Diks J Nio D Jongkind V | | 0，，： | 1 |
| 16 | Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis 显示文摘 | Cahen DL Gouma D J Nio Y | 2007 | N Engl J Med2007，356，7： | 1 |
| 17 | Spectral trend attribute analysis:applications in the stratigraphic analysis of wireline logs显示文摘 | Nio S D Brouwer J Smith D | 2005 | First Break2005，23，4： | 1 |
| 18 | The estimation of palaeohydynamic processes from subtidal deposits using time series analysis methods 显示文摘 | Yang C S Nio S D | 1985 | Sedimentology1985，32，： | 1 |
| 19 | Sound insulation provided by single and double panel walls-a comparison of analytical solution versus experimental results 显示文摘 | António J Mateus D | 2003 | Applied Acoustics2003，65，： | 1 |
| 20 | Spectral trend attribute analysis: Applications in the stratigraphic analysis of wireline logs 显示文摘 | Nio SD Brouwer J Smith D Jonh M Bhm A | 2005 | First Break2005，23，4： | 1 |
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