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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Short and long term fate of human AMSC subcutaneously injected in mice显示文摘AIM:To study the ability of human adipose-derived mesenchymal stem cells(AMSCs)to survive over the short and long term,their biodistribution and their biosafety in vivo in tumor-prone environments.METHODS:We subcutaneously injected human AMSCs from different human donors into immunodeficient SCID mice over both short-(2 and 4 mo)and long-(17 mo)term in young,and aged tumor-prone mice.Presence of human cells was studied by immunohistochemistry and polymerase chain reaction analysis in all organs of injected mice.RESULTS:Subcutaneously injected AMSCs did not form teratomas at any time point.They did not migrate but remained at the site of injection regardless of animal age,and did not fuse with host cells in any organ examined.AMSCs survived in vivo for at least 17 mo after injection,and differentiated into fibroblasts of the subdermic connective tissue and into mature adipocytes of fat tissue,exclusively at the site of injection.CONCLUSION:Our results support the assertion that AMSC may be safe candidates for therapy when injected subcutaneously because of their long term inability to form teratomas. | Pilar López-Iglesias Alejandro Blázquez-Martínez Jorge Fernández-Delgado Javier Regadera Manuel Nistal Maria P De Miguel | 2011 | World Journal of Stem Cells2011，3，6： | 5 |
| 3 | 猪轮状病毒感染显示文摘轮状病毒是影响新生仔猪的几种重要的肠道致病因子之一。它们可导致仔猪爆发肠胃炎。病原学轮状病毒是一种RNA病毒,其特点是有一个二十面的衣壳结构(图1),衣壳外无覆盖物。研究表明,该病毒至少有7种不同的血清群(A、B、c、D、E、F和G血清群)。 | 马晓迪 Ana Carvajal Pedro Rubio Nistal | 2012 | 国外畜牧学(猪与禽)2012，，4： | 3 |
| 4 | Long-term results of the augmented PFNA: a prospective multicenter trial显示文摘 | C. Kammerlander H. Doshi F. Gebhard A. Scola C. Meier W. Linhart M. Garcia-Alonso J. Nistal M. Blauth | 2014 | Archives of Orthopaedic and Trauma Surgery2014，，3： | 1 |
| 5 | p-SMAD2/3 and DICER promote pre-miR-21 processing during pressure over- load-associated myocardial remodeling显示文摘 | GARCIA R NISTAL J F MERINO D | 2015 | Biochim Biophys Ac- ta2015，1852，7： | 1 |
| 6 | Testicular mierolithiasis in 2 children with bilateral eryptorchidism 显示文摘 | NISTAL M PANIAGUA R DIEZ-PARDO J A | 1979 | J Uro11979，121，： | 1 |
| 7 | An Intelligent Tuto- ring Module Controlled by BDI Agents for an E- learning Platform 显示文摘 | Fonte F A M Burguillo J C Nistal M L | 2012 | Expert Systems with Applications2012，39，8： | 1 |
| 8 | Granulomatous epididymal lesion of possible ischemic origin 显示文摘 | Nistal M Maate A Paniagua R | 1997 | Am J Surg Pathol1997，21，8： | 1 |
| 9 | In vivo experimental as-sessment of polytetrafluoroethylene trileaflet heartvalve prosthesis显示文摘 | Nistal F Garcia-Martinez V Arbe E Fernandez D Artinano E Mazorra F | 1990 | J Thorac Cardiovasc Surg1990，99，： | 1 |
| 10 | Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients显示文摘 | Ana V. Villar Raquel García David Merino Miguel Llano Manuel Cobo Cecilia Montalvo Rafael Martín-Durán María A. Hurlé J. Francisco Nistal | 2012 | International Journal of Cardiology2012，，： | 1 |
| 11 | Differences in faecal bacteria populations and faecal bacteria metabolism in healthy adults and celiac disease patients显示文摘 | Esther Nistal Alberto Caminero Santiago Vivas José M. Ruiz de Morales Luis E. Sáenz de Miera Leandro B. Rodríguez-Aparicio Javier Casqueiro | 2012 | Biochimie2012，，8： | 1 |
| 12 | In vivo experimental assessment of polytetralluoroethylene trileaflet heart valve prosthesis 显示文摘 | Nistal F Garcia-Martinez V Arbe E | 1990 | J Thorac Cardiovasc Surg1990，99，： | 1 |
| 13 | Testicular microlithiasis in 2 children with bilateral eryptorchidism 显示文摘 | Nistal M Paniagua R Diez - Pardo JA | 1979 | J Urol1979，2，4： | 1 |
| 14 | Degeneration in porcine bioprosthetic cardiac valves:incidence of primary tissue failure among 938 bioprostheses at risk 显示文摘 | Gallo I Ruiz B Nistal F | 1984 | Am J Cardiol1984，53，8： | 1 |
| 15 | Malignant fibrous histiocytoma of the larynx显示文摘 | Bernaldez R Nistal M Kaiser C | 1991 | Larygol Otol1991，105，2： | 1 |
| 16 | Cystic Transformation of the Rete Testis显示文摘 | Manuel Nistal Alberto Mate Ricardo Paniagua | 1996 | The American Journal of Surgical Pathology1996，，10： | 1 |
| 17 | Cystic transformation and calcium oxalate deposits in rete testis and efferent ducts in dialysis patients显示文摘 | Manuel Nistal JoséA Jimenez-Heffernan Manuel Garcia-Viera Ricardo Paniagua | 1996 | Human Pathology1996，，4： | 1 |
| 18 | Imaging tests in chronic thromboembolic pulmonary hypertension显示文摘 | Nistal MA Martín MT | 2009 | Arch Bronconeumol2009，45，6： | 1 |
| 19 | Retioperitoneal Castleman's disease with colon cancer: a rare association显示文摘 | Raposo C Nistal M De Castro Caxpe J | 2008 | Clin Transl Oncol2008，10，4： | 1 |
| 20 | Simultaneous Serological Evidence of Actinobacillus pleuropneumoniae,PRRS,Aujeszky's Disease and Influenza Viruses in Spanish Finishingpigs显示文摘 | Gutiérrez Martín C B Rodríguez Delgado O Alvarez Nistal D | 2000 | Res Vet Sci2000，68，1： | 1 |
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