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| 1 | Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps:A meta-analysis and metaregression with single arm analysis显示文摘BACKGROUND Endoscopic submucosal dissection(ESD)has shown to be effective in management of colorectal neoplasm in the Asian countries,while its implementation in Western countries where endoscopic mucosal resection(EMR)is preferred is still debatable.AIM To compare the surgical,histological,and oncological outcomes between ESD and EMR in the treatment of colorectal polyps,with subgroup analysis comparing the efficacy of ESD and EMR between Japan and the rest of the world.METHODS Embase and Medline databases were searched from inception to October 2020 in accordance with PRISMA guidelines for studies comparing en bloc,complete resection,margin involvement,resection time,need for additional surgery,complications,and recurrence rate of ESD with EMR.RESULTS Of 281344 colorectal polyps from 21 studies were included.When compared to EMR,the pooled analysis revealed ESD was associated with higher en bloc and complete resection rate,and lower lateral margin involvement and recurrence.ESD led to increased procedural time,need for additional surgery,and perforation risk.No significant difference in bleeding risk was found between the two groups.Meta-regression analysis suggested only right colonic polyps correlated with an increased perforation risk in ESD.Confounders including polyp size and invasion depth did not significantly influence the en bloc and complete resection rate,bleeding risk and recurrence.In subgroup analysis,Japan performed better than the rest of the world in both ESD and EMR with perforation risk of 4%and 0.0002%,respectively,as compared to perforation risk of 8%and 1%,respectively,in reports coming from rest of the world.CONCLUSION ESD resulted in better resection outcomes and lower recurrence compared to EMR.With appropriate training,ESD is preferred over EMR as the first-line therapy for resection of colorectal polyps,without restricting to lesions greater than 20 mm and those with high suspicion of submucosal invasion. | Xiong Chang Lim Kameswara Rishi Yeshayahu Nistala Cheng Han Ng Snow Yunni Lin Darren Jun Hao Tan Khek-Yu Ho Choon-Seng Chong Mark Muthiah | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 2 | Angiotensin II-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells显示文摘 | Wei Y Sowers JR Nistala R | 2006 | Biol Chem2006，281，35： | 1 |
| 3 | Angiotensin receptor blockers for the reduction of proteinuria in diabetic patients with overt nephropathy: results from the AMADEO study 显示文摘 | Bichu P Nistala R Khan A | 2009 | Vasc Health Risk Manag2009，5，1： | 1 |
| 4 | Gestational diabe tes and the offspring: Implications in the development of the car- di0renal metabolic syndrome in offspring 显示文摘 | Garcia- Vargas L Addison SS Nistala R | 2012 | Cardiorenal Med2012，2，2： | 1 |
| 5 | Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment 显示文摘 | Nistala K Adams S Cambrook H | 2010 | Proc Natl Acad Sci USA2010，107，14： | 1 |
| 6 | The emerging role of biomarkers in diabetic and hypertensive chronic kidney disease显示文摘 | Chaudhary K Phadke G Nistala R | | 0，，01： | 1 |
| 7 | The emerging role of biomarkers in diabetic and hypertensive chronic kidney disease 显示文摘 | Chaudhary K Phadke G Nistala R | 2010 | Curr Diab Rep2010，10，1： | 1 |
| 8 | Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment 显示文摘 | Whaley-Connell Adam Habibi Javad Nistala Ravi | 2008 | Hyper- tension2008，51，2： | 1 |
| 9 | Thl7 and regulatory T cells: rebalancing pro-and anti-inflammatory forces in autoimmune arthritis显示文摘 | Nistala K Wedderburn LR | 2009 | Rheumatology(Oxford)2009，48，6： | 1 |
| 10 | Angiotensin II-induced NADPH oxidase activation impairs insulin signa-ling in skeletal muscle cells 显示文摘 | WEI Y SOWERS J H NISTALA R | 2006 | J Biol Chem2006，281，35： | 1 |
| 11 | Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment 显示文摘 | WHALEY-CONNELL A HABIBI J NISTALA R | 2008 | Hy- pertension2008，51，2： | 1 |
| 12 | Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat显示文摘 | WHALEY-CONNELL AI HABIBI J NISTALA R | 2012 | Regul Pept2012，176，13： | 1 |
| 13 | Attenuation of NADPH oxidase activation and glomerular filtration barrier remodefing with statin treatment显示文摘 | Whlacy- Connell A Habibi J Nistala R | 2008 | Hypertension2008，51，： | 1 |
| 14 | Gestatlonal diabetes and the offspring: implications in the development of the cardiorenal metabolic syndrome in offspring 显示文摘 | Gareia-Vargas L Addison SS Nistala R | 2012 | Cardiorenal Med2012，2，2： | 1 |
| 15 | Th17 and regulatory T cells:rebalancing pro-and anti-inflammatory forces in autoimmune arthritis显示文摘 | Nistala K Wedderburn LR | | 0，，： | 1 |
| 16 | Gestational diabetes and the offspring:implications in the development of the cardiorenal metabolic syndrome in offspring显示文摘 | Garcia-Vargas L Addison SS Nistala R | | 0，，： | 1 |
| 17 | Thl7 and regulatory T cells: rebalancing pro-and anti-inflammatory forces in autoim- mune arthritis显示文摘 | Nistala K Wedderburn LR | 2009 | Rheumatology2009，48，6： | 1 |
| 18 | Angiotensin Ⅱ-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells显示文摘 | Wei Y Sowers JR Nistala R | 2006 | J Biol Chem2006，281，35： | 1 |
| 19 | Interleukin - 17 - producing T cells are enriched in the joints of children with arthritis, but have a re- ciprocal relationship to regulatory T cell numbers显示文摘 | Nistala K Moncrieffe H Newton KR | 2008 | Arthritis Rheum2008，58，3： | 1 |
| 20 | Th 17 and regulatory T cells : rebalancing pro- and anti-lnflammatory forces in autoimmune arthritis 显示文摘 | Nistala K Wedderburn LR | 2009 | Rheumatology2009，48，6： | 1 |
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