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| 1 | Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions显示文摘MiR-219 and miR-338(miR-219/miR-338)are oligodendrocyte-specific microRNAs.The overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes,which may enhance axonal remyelination after nerve injuries in the central nervous system(CNS).As such,the delivery of miR-219/miR-338 to the CNS to promote oligodendrocyte precursor cell differentiation,maturation and myelination could be a promising approach for nerve repair.However,nerve injuries in the CNS also involve other cell types,such as microglia and astrocytes.Herein,we investigated the effects of miR-219/miR-338 treatment on microglia and astrocytes in vitro and in vivo.We found that miR-219/miR-338 diminished microglial expression of pro-inflammatory cytokines and suppressed astrocyte activation.In addition,we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in vitro.Collectively,our results suggest miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve injuries.All experimental procedures were approved by the Institutional Animal Care and Use Committee(IACUC),Nanyang Technological University(approval No.A0309 and A0333)on April 27,2016 and October 8,2016. | Lan Huong Nguyen William Ong Kai Wang Mingfeng Wang Dean Nizetic Sing Yian Chew | 2020 | Neural Regeneration Research2020，15，4： | 11 |
| 2 | Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity and Protect Against Lethal Systemic Infection显示文摘Staphylococcus aureus(S.aureus)is a leading human pathogen capable of producing severe invasive infections such as bacteremia,sepsis,and endocarditis with high morbidity and mortality,exacerbated by the increasingly widespread antibiotic resistance exemplified by methicillin-resistant strains(MRSA).S.aureus pathogenesis is fueled by the secretion of toxins—such as the membrane-damaging pore-forming atoxin,which have diverse cellular targets including the epithelium,endothelium,leukocytes,and platelets.Here,we examine the use of human platelet membrane-coated nanoparticles(PNPs)as a biomimetic decoy strategy to neutralize S.aureus toxins and preserve host cell defense functions.The PNPs blocked platelet damage induced by S.aureus secreted toxins,thereby supporting platelet activation and bactericidal activity.Likewise,the PNPs blocked macrophage damage induced by S.aureus secreted toxins,thus supporting macrophage oxidative burst,nitric oxide production,and bactericidal activity,and diminishing MRSA-induced neutrophil extracellular trap release.In a mouse model of MRSA systemic infection,PNP administration reduced bacterial counts in the blood and protected against mortality.Taken together,the results from the present work provide a proof of principle of the therapeutic benefit of PNPs in toxin neutralization,cytoprotection,and increased host resistance to invasive S.aureus infection. | Jwa-Kyung Kim Satoshi Uchiyama Hua Gong Alexandra Stream Liangfang Zhang Victor Nizet | 2021 | Engineering2021，7，8： | 2 |
| 3 | Extracellular virulence factors of group B Streptococci显示文摘 | LIU G Y NIZET V | 2004 | Front Biosci2004，9，： | 1 |
| 4 | Prevalence and mechanisms of resistance to fluoroquinolones in Helicobacter pylori strains from patients living in Belgium 显示文摘 | BOGAERTS P BERHIN C NIZET H | 2006 | Helicobacter2006，11，5： | 1 |
| 5 | Antimicrobial susceptibility of anaerobic bacteria in Belgium as determined by E-test methodology 显示文摘 | Glupczynski Y Berhin C Nizet H | 2009 | Eur J Clin Infect Dis2009，28，3： | 1 |
| 6 | HIF transcription factors, inflammation, and immunity 显示文摘 | Palazon A Goldrath A W Nizet V | 2014 | Immunity2014，41，4： | 1 |
| 7 | Liposuction in benign sym- metric lipomatosis: sense or senseless? 显示文摘 | Verhelle NA Nizet JL Vanden HB | 2003 | Aesthetic Plast Surg2003，27，4： | 1 |
| 8 | Interdependence of hypoxic and innate immune responses 显示文摘 | Nizet V Johnson RS | 2009 | Nat Rev Immunol2009，9，9： | 1 |
| 9 | Innate antimicrobial peptide protects the skin from invasive bacterial infection显示文摘 | Nizet V Ohtake T Lauth X | | 0，，6862： | 1 |
| 10 | Interdependence of hypoxic and innate immune responses 显示文摘 | Nizet V Johnson RS | 2009 | Nat Rev Immunol2009，9，9： | 1 |
| 11 | Control of partial digestion combining the enzymes dam methylase and MboI 显示文摘 | HOHEISEL J D NIZETIC D LEHRACH H | 1989 | Nucleic Acids Research1989，17，23： | 1 |
| 12 | Role of the hypoxia inducible factors in iron metabolism 显示文摘 | Peyssonnaux C Nizet V Johnson RS | 2008 | Cell Cycle2008，7，1： | 1 |
| 13 | Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells显示文摘 | CHARLAND N NIZET V RUBENS C E | 2000 | Infect Immun2000，68，2： | 1 |
| 14 | Skin microbiota: a source of disease or defence显示文摘 | COGEN A L NIZET V GALLO R L | 2008 | British Journal of Der- matology2008，158，3： | 1 |
| 15 | Hypoxia inducible factor (HIF) function in innate immunity and infection显示文摘 | inkernagel A Johnson R Nizet V | 2007 | J Mol Med2007，85，： | 1 |
| 16 | IKKbeta/NF-kappaB and the miscreant macrophage显示文摘 | Timmer A M Nizet V | 2008 | J Exp Med2008，2115，6： | 1 |
| 17 | Long-term follow-up of residual disease in acute lymphoblastic leukemia patients in complete remission using clonogeneic lgH probes and the polymerase chain reaction显示文摘 | Nizet Y Daele SV Lewalle P | 1993 | Blood1993，82，5： | 1 |
| 18 | Innate immunity gone awry:linking microbial infections to chronic inflammation and cancer显示文摘 | Karin M Lawrence T Nizet V | 2006 | Cell2006，124，4： | 1 |
| 19 | Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection显示文摘 | Pinheiro da Silva F Nizet V | 2009 | Apoptosis2009，14，4： | 1 |
| 20 | Porous pellets as drug delivery system显示文摘 | Cosijns A Nizet D Nikolakakis I | 2009 | Drug Dev Ind Pharm2009，35，6： | 1 |
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