|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy显示文摘AIM:To evaluate whether metabolic factors are related to distant recurrence of hepatocellular carcinoma(HCC) and survival after curative treatment.METHODS:This retrospective study included 344 patients whose HCC was treated curatively by radiofrequency ablation(RFA) therapy.The mean age was 67.6 years and the mean observation period was 4.04 years.The etiological background of liver disease was hepatitis B virus infection in 30,hepatitis C virus infection in 278,excessive alcohol drinking in 9,and other in 27 patients.The Child-Pugh classification grade was A(n = 307) or B(n = 37).The number of HCC nodules was one in 260,two in 61,and three in 23 patients.For surveillance of HCC recurrence after curative therapy with RFA,patients were radiologically evaluated every 3 mo.Factors associated with distant recurrence of HCC or survival were studied.RESULTS:Inadequate maintenance of blood glucose in diabetic patients was associated with higher incidence of distant recurrence.The 1-,2-,and 3-year recurrence rates were significantly higher in diabetic patients with inadequate maintenance of blood glucose compared with the others:50.6% vs 26.8%,83.5% vs 54.4%,and 93.8% vs 73.0%,respectively(P = 0.0001).Inadequate maintenance of blood glucose was an independent predictor of distant recurrence [adjusted relative risk 1.97(95%CI,1.33-2.91),(P = 0.0007)] after adjustment for other risk factors,such as number of HCC nodules [2.03(95%CI,1.51-2.73),P < 0.0001] and initial level of serum alpha fetoprotein(AFP) [1.43(95%CI,1.04-1.97),P = 0.028].Obesity was not an independent predictor of recurrence.The incidence of distant recurrence did not differ between diabetic patients with adequate maintenance of blood glucose and non-diabetic patients.Among 232 patients who had HCC recurrence,138 had a second recurrence.The 1-,2-,and 3-year rates of second recurrence were significantly higher in diabetic patients with inadequate maintenance of blood glucose than in the others:9.0% vs 5.9%,53.1% vs 24.3%,and 69.6% vs 42.3%,respectively(P = 0.0021).Inadequate maintenance of blood glucose in diabetic patients [1.99(95%CI,1.23-3.22),P = 0.0049] and presence of multiple HCC nodules [1.53(95%CI,1.06-2.22),P = 0.024] were again significantly associated with second HCC recurrence.Inadequate maintenance of blood glucose in diabetic patients was also a significant predictor of poor survival [2.77(95%CI,1.38-5.57),P = 0.0046] independent of excessive alcohol drinking [6.34(95%CI,1.35-29.7),P = 0.019],initial level of serum AFP [3.40(95%CI,1.88-6.18),P < 0.0001] and Child-Pugh classification grade B [2.24(95%CI,1.12-4.46),P = 0.022].Comparing diabetic patients with inadequate maintenance of blood glucose vs the others,the 1-,2-,and 3-year survival rates were significantly lower in diabetic patients with inadequate maintenance of blood glucose:92% vs 99%,85% vs 96%,and 70% vs 92%,respectively(P = 0.0003).CONCLUSION:Inadequate maintenance of blood glucose in diabetic patients is a significant risk factor for recurrence of HCC and for poor survival after curative RFA therapy. | Takanori Hosokawa Masayuki Kurosaki Kaoru Tsuchiya Shuya Matsuda Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Toru Nakata Takashi Nishimura Shoko Suzuki Ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Namiki Izumi | 2013 | World Journal of Gastroenterology2013，19，2： | 12 |
| 2 | Allogeneic hematopoietic stem cell transplantation for advanced extranodal natural killer/T-cell lymphoma, nasal type显示文摘 | Daisuke Ennishi Yoshinobu Maeda Nobuharu Fujii Eisei Kondo Katsuji Shinagawa Kazuma Ikeda Koichi Ichimura Tadashi Yoshino Mitsune Tanimoto | 2011 | Leukemia & Lymphoma2011，，7： | 1 |
| 3 | Experimental Study on Collapse Mechanism of Tunnel Lining and Effect of Reinforcing Material on Load-bearing Capacity of Tunnel Lining 显示文摘 | Hideto Mashimo Atsushi Kusaka Nobuharu Isago Tsutomu Kitani and Shinobu Kaise | 2008 | Proceedings of Japan Society of Civil Engineers2008，64，3： | 1 |
| 4 | Monitoring and mathematical modeling of mitochondrial ATP in myotubes at single-cell level reveals two distinct population with different kinetics显示文摘Backgrounds ATP is the major energy source for myotube contraction,and is quickly produced to compensate ATP consumption and to maintain sufficient ATP level.ATP is consumed mainly in cytoplasm and produced in mitochondria during myotube contraction.To understand the mechanism of ATP homeostasis during myotube contraction,it is essential to monitor mitochondrial ATP at single-cell level,and examine how ATP is produced and consumed in mitochondria.Methods:We established C2C12 cell line stably expressing fluorescent probe of mitochondrial ATP,and induced differentiation into myotubes・We gave electric pulse stimulation to the differentiated myotubes,and measured mitochondrial ATP.We constructed mathematical model of mitochondrial ATP at single-cell level,and analyzed kinetic parameters of ATP production and consumption.Results:We performed hierarchical clustering analysis of time course of mitochondrial ATP,which resulted in two clusters.Cluster 1 showed strong transient increase,whereas cluster 2 showed weak transient increase.Mathematical modeling at single-cell level revealed that the ATP production rate of cluster 1 was larger than that of cluster 2,and that both regulatory pathways of ATP production and consumption of cluster 1 were faster than those of cluster 2.Cluster 1 showed larger mitochondrial mass than cluster 2,suggesting that cluster 1 shows the similar property of slow muscle fibers,and cluster 2 shows the similar property of fast muscle fibers.Conclusions Cluster 1 showed the stronger mitochondrial ATP increase by larger ATP production rate,but not smaller consumption.Cluster 1 might reflect the larger oxidative capacity of slow muscle fiber. | Naoki Matsuda Ken-ichi Hironaka Masashi Fujii Takumi Wada Katsuyuki Kunida Haruki Inoue Miki Eto Daisuke Hoshino Yasuro Furuichi Yasuko Manabe Nobuharu LFujii Hiroyuki Noji Hiromi Imamura Shinya Kuroda | 2020 | Quantitative Biology2020，8，3： | 1 |
| 5 | Characterization of ethylene effects on sex determination in cucumher plants显示文摘 | Seiji Yamasaki Nobuharu Fujii Hideyuki Takahashi | 2003 | Sex Plant Reprod2003，16，： | 1 |
| 6 | Wind induced pointing errors and surface deformation of a 10-m submillimeter antenna 显示文摘 | NOBUHARU UKITA HAJIME EZAWA SACHIKO ON- ODERA | 2010 | Pro- ceeding of SPIE2010，7733，： | 1 |
| 7 | Reconstruction of phase objects from experimental far field intensities by exponential filtering显示文摘 | Nobuharu Nakajima | 1990 | Applied Optics1990，29，： | 1 |
| 8 | α‐fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C显示文摘 | Yasuhiro Asahina Kaoru Tsuchiya Takashi Nishimura Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Takanori Hosokawa Ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Masayuki Kurosaki Nobuyuki Enomoto Mina Nakagawa Sei Kakinuma Mamoru Wat | 2013 | Hepatology2013，，4： | 1 |
| 9 | Estimation of shear characteristics degradation and stress-strain rela- tionship of saturated clays after cyclic loading 显示文摘 | Tamotsu M Mohamed A B Nobuharu A | 1992 | Soils and Foundations1992，32，1： | 1 |
| 10 | Suppression of high-mobility group box-1 and receptor for advanced glycation end-product axis by polymyxin B-immobilized fiber hemoperfusion in septic shock patients显示文摘 | Tsukasa N Eiichi S Nobuharu F | 2011 | J Crit Care2011，26，6： | 1 |
| 11 | AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle显示文摘 | NICOLAS MUSI TATSUYA HAYASHI NOBUHARU FUJ | 2001 | Physiol Endocrin Metab2001，280，： | 1 |
| 12 | A Galilean invariant model of the lattice Boltzmann method for multiphase fluid flows using free-energy approach显示文摘 | Takaji Inamuro Nobuharu konishi fumimaru ogino | 2000 | Computer Physics Communications2000，129，： | 1 |
| 13 | CD34^+CD7^+ leukemic progenitor cells may be involved in maintenance and clonal evolution of chronic myeloid leukemia显示文摘 | Nobuharu Kosugi Yasuhiro Ebihara Tatsutoshi Nakahata | 2005 | Clin Cancer Res2005，11，： | 1 |
| 14 | Prognostic factors of pulmonary metastasectomy for colorectal carcinomas 显示文摘 | Fengshi Chen Nobuharu Hanaoka Kiyoshi Sato | 2009 | World J Surg2009，33，： | 1 |
| 15 | Mechanistic study of the reduction of oxygen in air electrode with manganese oxides as electrocatalysts 显示文摘 | MAO Lan-qun ZHANG Dun Tadashi Sotomura Kenichi Nakatsu Nobuharu Koshiba Takeo Ohsaka | 2003 | Electrochimica Acta2003，48，： | 1 |
| 16 | p38 gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle显示文摘 | Ho Richard C Alcazar Oscar Fujii Nobuharu | 2004 | Ameriean Journal of Physiology2004，286，2： | 1 |
| 17 | Relationship between the structures and the antitumor activities of tannins显示文摘 | Kenichl M Nobuharu K Ryozo K | 1987 | Chem Pharm Bull1987，35，2： | 1 |
| 18 | Relationship between the structures and the antitumor activities of tannins显示文摘 | Nobuharu K Ryozo K etal | 1987 | Chem Pharm Bull1987，35，2： | 1 |
| 19 | Increased levels of soluble receptor for advanced glycation end products (sRAGE) and high mobility group box 1 (HMGB1) are associated with death in patients with acute respiratory distress syndrome显示文摘 | Tsukasa Nakamura Eiichi Sato Nobuharu Fujiwara Yasuhiro Kawagoe Sayaka Maeda Sho-ichi Yamagishi | 2010 | Clinical Biochemistry2010，，8： | 1 |
| 20 | Hormonal interactions during root tropic growth: hydrotropism versus gravitropism显示文摘 | Hideyuki Takahashi Yutaka Miyazawa Nobuharu Fujii | 2009 | Plant Molecular Biology2009，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员