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| 1 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 2 | Field Test on Current Carrying Performances of 1 000 kV GIS显示文摘 | YOSHIBUMI Y NOBUHIRO S MASATOMO O | 1999 | IEEE Trans1999，，2： | 1 |
| 3 | Development of tissue-engineeredhuman periodontal ligament constructs with intrinsic angiogenicpotential显示文摘 | Nobuhiro N Ayumi H Nao O | 2009 | Cells Tissues Organs2009，190，6： | 1 |
| 4 | Steam turbine new sealing and clearance-controlling technologies显示文摘 | Nobuhiro O | 2007 | Kami Pa Gikyoshi/Japan Tappi Journal2007，61，5： | 1 |
| 5 | Liquid crystal phase gratings using photo regulated photocrosslinkable polymer liquid crystals 显示文摘 | TOMOYUKI S HIROSHI O NOBUHIRO K | 2005 | Appl Phys Lett2005，87，16： | 1 |
| 6 | Anti-invasive activity of niacin and trigonelline against cancer cells显示文摘 | Nobuhiro H Rieko O Yutaka M | | 0，，03： | 1 |
| 7 | Relapsed small cell lung cancer: treatment options and latest developments 显示文摘 | Nobuhiro A Yoshihiro O Norihiro K | 2014 | Therapeutic Adv in Med Oncol2014，6，2： | 1 |
| 8 | Influence of the Alloy Morphology on the Kinetics of AB5-Type Metal Hydride Electrodes显示文摘 | Daniel C Nobuhiro K Andreas O | 1999 | J Alloys Compd1999，285，： | 1 |
| 9 | Primary hepatic eaareinoid tumor: a case report 显示文摘 | Yutaka M Nobuhiro O Keisei F | 2000 | Hepatogastroenterology2000，47，4： | 1 |
| 10 | Rising Tc in Bi and Cu co-doped BaTiO3显示文摘 | NOBUHIRO K HIDEYUKI O KEIKO S | 2010 | Mater Lett2010，64，3： | 1 |
| 11 | Biosynthesis of plant pigments: anthoeyanins, betalains and carote- noids 显示文摘 | Yoshikazu T Nobuhiro S Akemi O | 2006 | The Plant Journal2006，54，： | 1 |
| 12 | Early diagnosis and treatment are crucial for the survival of Pneumocystis pneumonia patients without human immunodeficiency virus infection显示文摘 | Nobuhiro A Shinji M Yoshihiro O | | 0，，06： | 1 |
| 13 | Genipin,a metabolite derived from the herbal medicine Inchin-ko-to,and suppression of Fas-induced lethal liver apoptosis in mice 显示文摘 | MASAHIRO Y NAOKO M NOBUHIRO O | 2000 | Gastroenterlogy2000，118，： | 1 |
| 14 | Determination of flunarizine in serum by high performance liquid chromatography and its clinical application显示文摘 | KAZUSABURO K NOBUHIRO K MASAKO O | 1988 | Yakugaku Zasshi1988，108，3： | 1 |
| 15 | Antirheumatic agents: Novel methotrexate derivatives bearing a benzoxazine or benzothiazine moiety显示文摘 | Hiroharu M Nobuhiro O Masahiko M | 1997 | J Med Chem1997，40，1： | 1 |
| 16 | Synthesis and surface-active properties of trimeric type anionic surfac- tants derived from tris (2-aminoethyl) amine显示文摘 | TOMOKAZU Y NOBUHIRO K EMIKA O | 2004 | J Surfactants Deterg2004，7，1： | 1 |
| 17 | Development of Ferritic Stainless Steel YUS 450 with High Heat Resistance for Automotive Exhaust System Components 显示文摘 | Nobuhiro F Keiiehi O Eiji S et ol | 1996 | Nippon Steel Technical Report1996，71，7： | 1 |
| 18 | Mullerian anomalies and recurrent miscarriage显示文摘 | Mayumi S O Yasuhiko O Nobuhiro S | 2013 | Obstet Gynecol2013，25，10： | 1 |
| 19 | 查看详情显示文摘 | ShodaY Nakamoto A Goto M Tokuhara W Noritake Y Katahira S Nobuhiro I Kazunori N Chiaki O Noriho K | | 0，，01： | 1 |
| 20 | Metal hydride anodes for nickel-hydrogen secondary battery显示文摘 | Tetsuo S Hirosh M Nobuhiro K Akihiko K Keisuke O Hiroshi I | 1990 | J Electrochem Soc1990，137，3： | 1 |
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