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| 1 | Immune dysfunction in cirrhosis显示文摘Innate and adaptive immune dysfunction,also referred to as cirrhosis-associated immune dysfunction syndrome,is a major component of cirrhosis,and plays a pivotal role in the pathogenesis of both the acute and chronic worsening of liver function.During the evolution of the disease,acute decompensation events associated with organ failure(s),so-called acute-on chronic liver failure,and chronic decompensation with progression of liver fibrosis and also development of disease specific complications,comprise distinct clinical entities with different immunopathology mechanisms.Enhanced bacterial translocation associated with systemic endotoxemia and increased occurrence of systemic bacterial infections have substantial impacts on both clinical situations.Acute and chronic exposure to bacteria and/or their products,however,can result in variable clinical consequences.The immune status of patients is not constant during the illness;consequently,alterations of the balance between pro-and anti-in-flammatory processes result in very different dynamic courses.In this review we give a detailed overview of acquired immune dysfunction and its consequences for cirrhosis.We demonstrate the substantial influence of inherited innate immune dysfunction on acute and chronic inflammatory processes in cirrhosis caused by the pre-existing acquired immune dysfunction with limited compensatory mechanisms.Moreover,we highlight the current facts and future perspectives of how the assessment of immune dysfunction can assist clinicians in everyday practical decision-making when establishing treatment and care strategies for the patients with end-stage liver disease.Early and efficient recognition of inappropriate performance of the immune system is essential for overcoming complications,delaying progression and reducing mortality. | Nora Sipeki Peter Antal-Szalmas Peter L Lakatos Maria Papp | 2014 | World Journal of Gastroenterology2014，20，10： | 10 |
| 2 | Epidemiological,clinical and laboratory findings of infectious keratitis at Mansoura Ophthalmic Center,Egypt显示文摘● AIM: To analyze the epidemiological, clinical and laboratory findings of infectious keratitis. ● METHODS: A retrospective study on cases of infective keratitis, attended our institution from Mar. 2013 to Feb. 2015, was done at Mansoura Ophthalmic Center, Egypt. Corneal scrapings were performed and processed for direct microscopy and culture in appropriate media using standard laboratory protocols. ● RESULTS: Out of 245 patients enrolled for study, 247 corneal scrapings were obtained. Ocular trauma was the most common predisposing factor(51.4%), followed by diabetes mellitus(15.1%). Cultures were positive in 110 scraping samples(44.5%): 45.5% samples had pure fungal infection, 40% had pure bacterial infections and 10% had mixed fungal and bacterial growths. Acanthamoeba was detected in 5(4.5%) samples. The most common fungal pathogen was Aspergillus spp.(41%). The most common bacterial isolates were Staphylococcus aureus(38.2%) and Pseudomonas aeruginosa(21.8%).● CONCLUSION: Incidence of fungal keratitis is high in our region. Therapeutic approach can initially be based on clinical features and sensitivity/resistance patterns. Microbiological research should direct the antimicrobial treatment. Antibiotic resistance to fluoroquinolones and aminoglycosides is an important consideration. | Amani E Badawi Dalia Moemen Nora L El-Tantaw | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 2 |
| 3 | WUSCHEL induces shoot stem cell activity and developmental plas- ticity in the root meristem 显示文摘 | Gallois J - L Nora F R Mizukami Y | 2004 | Genes & Development2004，18，4： | 1 |
| 4 | Age and growth of the largemouth perch Percichthys colhuapiensis in the Negro River,Argentine Patagonia显示文摘 | Andrea L C Nora S | 2008 | Fisheries Research2008，92，： | 1 |
| 5 | An evaluation of the 30s chair stand test in older adults:frailty detection based on kinematic parameters from a single inertial unit显示文摘 | Nora M Pablo L Marisol G | 2013 | J Neuro- eng Rehabil2013，10，1： | 1 |
| 6 | Stability promotion of Ni/α-Al2O3 catalysts by tin added via surface organometallic chemistry on metal application in methane reforming processes 显示文摘 | Nora N Niehio Monica L Casella Gerardo F Santori | 2000 | Catal Today2000，62，23： | 1 |
| 7 | Cocaine-and amphetamine-regulated transcript (CART) acceler- ates the temination of FSH-induced ERK1/2 and AKT activation by regulating the expression and deg- radation of specific mitogen-activated protein kinase phosphatases in bovine granulosa cells显示文摘 | ARITRO S LV L H NORA B | 2008 | Mol En- docrinol2008，22，12： | 1 |
| 8 | Toxoplasma gondii infection among chronic hepatitis C patients:A casecontrol study显示文摘Objective:To determine the detection rate of anti-Toxoplasma gondii(T.gondii) IgG and IgM in chronic HCV patients attending the Department of Tropical Medicine Mansoura University hospital in Egypt.Methods:This study included 120 adult chronic HCV patients.81 decompensate cirrhosis(late-stage)and 39 chronic HCV non cirrhotic patients(early-stage) and40 healthy blood donors as controls.Serum samples uere examined for anti-Toxoplasma IgM and anti-Toxoplasma IgG antibodies by ELISA.Real-time RT-polymerase chain reaction assay was done for quantitation of hepatitis C virus.Results:Anti-T.gondii IgG antibodies were detected in 75(92.6%) of 81 late-stage cirrhotic patients.30(76.9%) of the 39 chronic HCV non cirrhotic patients(early-Stage) and in 6(15ft) of 40 controls with statistically significant difference(P<0.001).Anti-T.gondii IgM antibodies were found in 11(13.6%) in late stage patients,5(12.8%)in early stage and in 3(7.5%) of controls with no statistical significant difference(P=0.610).There was no correlation between stage of fibrosis and IgM or IgG antibodies positivity in our studied groups(P=0.526).High IgG levels significantly correlated with high viral load(P=0.026).Conclusions:Our findings suggest that the serious opportunistic T.gondii infection represent a potential significant risk for chronic HCV patients.So.toxoplasmosis should be considered in their investigations and follow-up. | Hala A El-Nahas Nora L El-Tantawy Raghda E Farag Argaya MA Alsalem | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，8： | 1 |
| 9 | Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Prehypertension: Relation to Endothelial Dysfunction显示文摘 | Giovanna Giannotti Carola Doerries Pavani S. Mocharla Maja F. Mueller Ferdinand H. Bahlmann Tibor Horvàth Hong Jiang Sajoscha A. Sorrentino Nora Steenken Costantina Manes Mario Marzilli K. Lenhard Rudolph Thomas F. Lüscher Helmut Drexler Ulf Landmesser | 2010 | Hypertension2010，，6： | 1 |
| 10 | Consrvation of gene repertoire but not gene order in pepper and tomato 显示文摘 | Steven D Tanksley Robert Bernatzky Nora L Lapitan | 1988 | Proceedings of the National Academy of Science of the USA1988，，85： | 1 |
| 11 | An open-label pilot study of St John's wort in juvenile depression显示文摘 | Robert L Finding Nora K | 2003 | J Am Acad Child Adolesc Psychiatry2003，908，： | 1 |
| 12 | Suppression of symptoms of citrus greening disease in the Philippines by treatment with tetracycline antiobiotics 显示文摘 | MARTINEZ A L NORA D M ARMEDILLA A L | 1970 | Plant Disease1970，，： | 1 |
| 13 | Exploiting the intrinsic hydrocarbon-degrading microbial capacities in oil tank bottom sludge and waste soil for sludge bioremediation显示文摘 | NORA B S PAULINE V G ALETTE A M L | 2015 | International Journal of Environmental Science and Technology2015，12，： | 1 |
| 14 | A molecular dynamics study of the inter-protein interactions in collagen fibrils显示文摘 | Ian S Nora H De L | | 0，，： | 1 |
| 15 | Commercial cell wall hydrolytic enzymes for producing pectin-enriched products from butternut ( Cucurbita moschata , Duchesne ex Poiret)显示文摘 | Eliana N. Fissore Nora M. Ponce Eva A. Wider Carlos A. Stortz Lía N. Gerschenson Ana M. Rojas | 2009 | Journal of Food Engineering2009，，3： | 1 |
| 16 | 2011 The inactive X chromosome adopts au- nique threedimensional conformation that is dependent on Xist RNA显示文摘 | Splinter E de Wit E Nora E P Klous P van de Werken H J Zhu Y Kaaij L J van ljcken W Gribnau J Heard E de Laat W | 2011 | Genes Development2011，25，13： | 1 |
| 17 | Comparison of ecophysiological characteristics between introduced and indigenous mangrove species in China显示文摘 | CHEN L Z TAM NORA F Y HUANG J H | 2008 | Estuarine Coastal and Shelf Science2008，79，： | 1 |
| 18 | Wear behavior of fiber laser textured tin coatings in a heavy loaded sliding regime 显示文摘 | Vandoni L Previtali B Nora Lecis | 2012 | Materials2012，5，11： | 1 |
| 19 | The predictive value of intraoperative somatosensory evoked potential monitoring: review of 244 procedures 显示文摘 | BEJJANI G K NORA P C VERA P L | 1998 | Neurosurgery1998，43，3： | 1 |
| 20 | Con- trasting patterns of urban expansion in Colombia, Ecuador, Peru, and Bolivia Between 1992 and 2009显示文摘 | Nora L Alvarez-Berrios Isabel K Par6s-Ramos T Mitchell Aide | 2013 | Ambio2013，42，1： | 1 |
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