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| 1 | Characterization of clarithromycin resistance in Malaysian isolates of Helicobacter pylori显示文摘AIM:To characterize the types of mutations present in the 23S rRNA genes of Malaysian isolates of clarithromycin-resistant Helicobacter pylori (H pylori).METHODS: Clarithromycin susceptibility of H pylori isolates was determined by E test. Analyses for point mutations in the domain V of 23S rRNA genes in clarithromycin-resistant and-sensitive strains were performed by sequence analysis of amplified polymerase chain reaction products. Restriction fragment length polymorphism was performed using Bsa-RESULTS: Of 187 isolates from 120 patients, four were resistant to clarithromycin, while 183 were sensitive. The MIC of the resistant strains ranged from 1.5 to 24 μg/mL. Two isolates had an A2142G mutation and another two had A2143G mutations. A T2182C mutation was detected in two out of four clarithromycin-resistant isolates and in 13 of 14 clarithromycin-sensitive isolates. Restriction enzyme analyses with Bsa-CONCLUSION: Clarithromycin resistance is an un-common occurrence among Malaysian isolates of H pylori strains and the mutations A2142G and A2143G detected were associated with low-level resistance. | Norazah Ahmad Wan Rasinah Zakaria Sheikh Anwar Abdullah Ramelah Mohamed | 2009 | World Journal of Gastroenterology2009，15，25： | 4 |
| 2 | Translational Genomics to Develop a Salmonella enterica Serovar Paratyphi A Multiplex Polymerase Chain Reaction Assay显示文摘 | Hong-Yu Ou Cindy Teh Shuan Ju Kwai-Lin Thong Norazah Ahmad Zixin Deng Michael R. Barer Kumar Rajakumar | 2007 | The Journal of Molecular Diagnostics2007，，5： | 2 |
| 3 | Ethnicity association of Helicobacter pylori virulence genotype and metronidazole susceptibility显示文摘AIM:To characterise the cag pathogenicity island in Helicobacter pylori(H.pylori) isolates by analysing the strains' vacA alleles and metronidazole susceptibilities in light of patient ethnicity and clinical outcome.METHODS:Ninety-five H.pylori clinical isolates obtained from patients with dyspepsia living in Malaysia were analysed in this study.Six genes in the cagPAI region(cagE,cagM,cagT,cag13,cag10 and cag67) andvacA alleles of theH.pylori isolates were identified by polymerase chain reaction.The isolates' metronidazole susceptibility was also determined using the E-test method,and the resistant gene was characterised by sequencing.RESULTS:More than 90% of the tested isolates had at least one gene in the cagPAI region,and cag67 was predominantly detected in the strains isolated from the Chinese patients,compared with the Malay and Indian patients(P < 0.0001).The majority of the isolates(88%) exhibited partial deletion(rearrangement) in the cagPAI region,with nineteen different patterns observed.Strains with intact or deleted cagPAI regions were detected in 3.2% and 8.4% of isolates,respectively.The prevalence of vacA s1m1 was significantly higher in the Malay and Indian isolates,whereas the isolates from the Chinese patients were predominantly genotyped as vacA s1m2(P = 0.018).Additionally,the isolates from the Chinese patients were more sensitive to metronidazole than the isolates from the Malay and Indian patients(P = 0.047).Although we attempted to relate the cagPAI genotypes,vacA alleles and metronidazole susceptibilities to disease outcome,no association was observed.The vacA alleles were distributed evenly among the strains with intact,partially deleted or deleted cagPAI regions.Interestingly,the strains exhibiting an intact cagPAI region were sensitive to metronidazole,whereas the strains with a deleted cagPAI were more resistant.CONCLUSION:Successful colonisation by different H.pylori genotypes is dependent on the host's genetic makeup and may play an important role in the clinical outcome. | Hanafiah Alfizah Awang Hamat Rukman Ahmad Norazah Razlan Hamizah Mohamed Ramelah | 2013 | World Journal of Gastroenterology2013，19，8： | 2 |
| 4 | Combustion characteristics of Malaysian oil palm biomass, sub-bituminous coal and their respective blends via thermogravimetric analysis (TGA) 显示文摘 | Siti Shawalliah Idris Norazah Abd Rahman Khudzir Iamail | 2012 | Biore- source Technology2012，123，1： | 1 |
| 5 | Mulecular fingerprinting of fusidic acid and rifampicin-resistant strains of methicillin-resistant staphylococcus aureus(MRSA) from Malaysian hospitals显示文摘 | Norazah A Lim V K E Koh Y T | 2002 | J Med Microbiol2002，51，： | 1 |
| 6 | Investigation on thermochemical behaviour of low rank Malaysian coal, oil palm biomass and their blends during pyrolysis via thermogravimetric analysis (TGA)显示文摘 | Siti Shawalliah Idris Norazah Abd Rahman Khudzir Ismail Azil Bahari Alias Zulkifli Abd Rashid Mohd Jindra Aris | 2010 | Bioresource Technology2010，，12： | 1 |
| 7 | Mulecular fingerprinting of fusidie acid and rifam picin-resistant strains of methicillin resist ant staphylococcus aureus(MRSA) from Malaysian hospitals显示文摘 | Norazah A Lim VKE Koh YT | 2002 | Med Microbiol2002，51，： | 1 |
| 8 | Molecular fingerprinting of fusidic acid and rifampicin-resistant strains of methicillin-resistant staphylococcus aureus (MRSA) from Malaysian hospitals显示文摘 | Norazah A Lim V K Koh Y T | 2002 | J Med Microbiol2002，51，12： | 1 |
| 9 | Resistotype of Helico- bacter pylori isolates:the impact on eradication outcome显示文摘 | Alfizah H Norazah A Hamizah R | 2014 | J Med Microbiol2014，63，5： | 1 |
| 10 | Using Mobile Device for Learning: From Students' Perspective显示文摘 | Norazah Mohd Suki Norbayah Mohd Suki | 2011 | US-China Education Review(A)2011，1，1X： | 1 |
| 11 | Comparison of chemical profiles of selected gaharu oils from peninsular Malaysia显示文摘 | Norazah M A Chang Y S Mailina J | | 0，，02： | 1 |
| 12 | Combustion characteristics of Malaysian oil palm biomass,sub-bituminous coal and their respective blends via thermogravimetric analysis(TGA)显示文摘 | Siti Shawalliah Idris Norazah Abd Rahman Khudzir Ismail | | 0，，01： | 1 |
| 13 | Comparison of chemical profiles of selected gaharu oils from peninsular Malaysia 显示文摘 | Norazah MA Chang YS Mailina J | 2008 | Mal J Anal Sei2008，12，2： | 1 |
| 14 | Occurrence of virulent genes a- mong environmental isolates of Legionella pneumophila serogroup 1 strains from various parts of peninsular Malaysia 显示文摘 | Revathy Arushothy Norazah Ahmad | 2008 | Tropical Bio- medicine2008，25，3： | 1 |
| 15 | Mulecular fingerprinting of fusidic acid and rifampicin- resistant strains of methicillin - resistant staphylococcus aureus(MRSA) from Malaysian hospitals显示文摘 | Norazah A Lim VKE Koh YT | 2002 | J Med Microbiol2002，51，： | 1 |
| 16 | Ahalysis of PCR-RAPD DNA and anhbioticsusceptibility profiles of antrum and corpus isolates of Helicobacter pylori from Malaysian patients 显示文摘 | Norazah A Norazah A Zaili Z | 2009 | Malays J Pathol2009，31，： | 1 |
| 17 | Overview on agent application to support collaborative learning interaction显示文摘 | Erlin Yusof Norazah Abdul Rahman Azizah | 2008 | 美中教育评论2008，5，1： | 1 |
| 18 | Analysis of PCR - RAPD DNA and antibiotic susceptibility profiles of antrum and corpus imlates of Helicobacter pylori from Malaysian patients 显示文摘 | Norazah A Rasinah WZ Zaili Z | 2009 | Malays J Pathol2009，31，1： | 1 |
| 19 | Combustion characteristics of Malaysian oil palm biomass,sub-bituminous coal and their respective blends via thermogravimetric analysis (TGA)显示文摘 | Siti S I Norazah A R Khudzir I | | 0，，11： | 1 |
| 20 | Resistotype of Helicobacter pylori isolates: the impact on eradication outcome显示文摘 | Alfizah H Norazah A Hamizah R | 2014 | J Med MicroN- ol2014，63，5： | 1 |
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