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| 1 | Glutathione depleting drugs, antioxidants and intestinal calcium absorption显示文摘Glutathione(GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them. | Luciana Moine María Rivoira Gabriela Díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni | 2018 | World Journal of Gastroenterology2018，24，44： | 5 |
| 2 | Autologous platelet transfusion in patients receiving high-dose chemotherapy and circulating progenitor cell transplansplantation for stage Ⅱ/Ⅲ breast cancer显示文摘 | Pedrazzoli P Noris P Perotti C | 1998 | Hamtologica1998，83，3： | 1 |
| 3 | Unifying views of tail-biting trellis constructions for linear block codes显示文摘 | Nori A V Shankar P | 2006 | IEEE Trans on Information Theory2006，52，10： | 1 |
| 4 | Investigational drugs in thrombotic thrombocytopenic purpura 显示文摘 | Noris P Balduini CL | 2011 | Expert (-)pin Investig Drugs2011，20，8： | 1 |
| 5 | Arbitrary control of coherent dynamics for distant qubits in a quantum network显示文摘 | Zheng S B Yang C P Nori F | 2010 | Phys Rev A2010，82，04： | 1 |
| 6 | Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients显示文摘 | Noris P Pecci A Di Bari F | | 0，，10： | 1 |
| 7 | Thrombotic microangiopathy,hemolytic uremic syndrome,and thromboticthrombocytopenic purpura显示文摘 | Ruggenenti P Noris M Remuzzi G | | Kidney Int0，60，3： | 1 |
| 8 | Endocrine disrupting chem- icals and testicular cancer:a case-control study显示文摘 | Nori F Carbone P Giordano F | 2006 | Arch En- viron Occup Health2006，61，2： | 1 |
| 9 | Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura显示文摘 | Ruggenenti P Noris M Remuzzi G | 2001 | Kidney Int2001，60，： | 1 |
| 10 | Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients显示文摘 | Noris P Pecci A Di Bari F | 2004 | Haematologica2004，89，： | 1 |
| 11 | Transfusion of plate- let concentrates cryopreserved with Thrombosol plus low-dose dimethylsulphoxide in patients with severe thrombocytopenia a pilot study显示文摘 | Pedrazzoli P Noris P Perotti C | 2000 | Br J Haematol2000，108，： | 1 |
| 12 | Altered cytoskeleton organization in platelets from patients with MYH9-related disease显示文摘 | Canobbio I Noris P Pecci A | 2005 | J Thromb Haemost2005，3，： | 1 |
| 13 | Tatconjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells 显示文摘 | Nori A Jensen KD Tijerina M Kopeckov6 P Kopecek J | 2003 | Bioconjug Chem2003，14，1： | 1 |
| 14 | Dynamic programming approximation for a stochastic inventory routing problem显示文摘 | Kleywegt A J Nori V S Savelsbergh M W P | 2004 | Transportion Science2004，38，： | 1 |
| 15 | Thrombotic microangiopathy hemolytic remic syndrome,and thrombotic thrombocytopenic Purpura显示文摘 | Ruggenenti P Noris M Remuzzi G | 2001 | Kidney Int2001，60，3： | 1 |
| 16 | The stochastic inventory routing problem with direct deliveries显示文摘 | Kleywegt A J Nori V S Savelsbergh M W P | 2002 | Transportation Science2002，36，1： | 1 |
| 17 | 查看详情显示文摘 | Zheng S B Yang C P Nori F | | 0，，： | 1 |
| 18 | Maternal diet and the risk of hypospadias and cryptorchidism in the offspring 显示文摘 | Giordano F Carbone P Nori F | 2008 | Paediatr Perinat Epidemiol2008，22，： | 1 |
| 19 | Use of matrix-assistedlaser desorption ionization-time of flight mass spectrometry toresolve complex clinical cases of patients with recurrentbacteremias显示文摘 | Nori P Ostrowsky B Dorokhova 0 | 2013 | J Clin Microbiol2013，51，6： | 1 |
| 20 | Thrombotic microangiopathy,hemolytic uremic syndrome,and thrombotic thrombocytopenic purpura显示文摘 | Ruggenenti P Noris M Remuzzi G | 2001 | Kidney Int2001，60，3： | 1 |
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