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| 1 | Developmental Lead Exposure Alters the Distribution of Protein Kinase C Activity in the Rat Hippocampus显示文摘Chronic low-level lead (Pb) exposure in children is known to cause a deficit in learning and memory. In vitro studies have demonstrated that Pb altered protein kinase C (PKC) activityt Especially, hippocampal PKC has been correlated with performance in several learning tasks. The effects of Pb exposure on hippocampal PKC were investigated during development at various postnatal ages: postnatal day (PN) 7, 14, 28, and 56. Two-tenth % Pb acetate was administered to pregnant and lactating dams and then administered to weanling rats in drinking water. PKC activity was measured in both membrane and cytosolic fractions from the hippocampi of the controls and Pb-exposed animals. Pb-induced increase in PKC activity in the cytosolic fraction was obsereved in the PN56 rats. In contrast, PKC activity was decreased by Pb at PN7 in the membrane fraction. Furthermore, a significant decrease in the ratio of membrane to cytosolic PKC activity which is representative of PKC distribution was observed in the PN28 and PN56 Pb-exposed rats relative to the same-age controls. This study indicates that chronic Pb exposure during development influences hippocampal PKC activity and distribution. These changes may be involved in the subclinical neurotoxicity of chronic Pb exposure in young children. | HWEI-HSIEN CHEN TANGENG MA ARTHUR S. HUME AND ING K. HO(Deportment of Pharmacology and Toxicology, University ofMississippi Medical Center, 2500 North State Street,Jackson, MS 39216, USA) | 1998 | Biomedical and Environmental Sciences1998，11，1： | 7 |
| 2 | Malignant tumors of the small intestine: a review of 144 cases显示文摘 | North JH Pack MS | 2000 | Am Surg2000，66，1： | 1 |
| 3 | A prospective,randomized study of spinal cord stimulation versus reoperation for failed back surgery syndrome:Initial results显示文摘 | North RB Kidd DH Lee MS | 1994 | Stereotact Funct Neurosurg1994，62，： | 1 |
| 4 | Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties 显示文摘 | North E J Scherman MS Bruhn DF | 2013 | Bioorg Med Chem2013，21，： | 1 |
| 5 | Malignant tumors of the small intestine: a review of 144 cases显示文摘 | North JH Pack MS | 2000 | Am Surg2000，66，1： | 1 |
| 6 | Screening a library of 1600 adamantyl ureas for anti-mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability 显示文摘 | Scherman MS North EJ Jones V | 2012 | Bioorg Med Chem2012，20，： | 1 |
| 7 | Cyclooxygenase polymoiphisms and risk of cardiovascular events : the Atherosclerosis Risk in Com- munities(ARIC) study 显示文摘 | Lee CR North KE Bray MS | 2008 | Clin Pharmacol Ther2008，83，1： | 1 |
| 8 | Prognostic factors for adeno-carcinoma of gallbladder:an analysis of 162 cases显示文摘 | North JH Pack MS Hong C | 1998 | Am Surg1998，64，43： | 1 |
| 9 | Malignant tumors of the small intestine: a review of 144 cases显示文摘 | North JH Pack MS | 2000 | Am Surg2000，66，1： | 1 |
| 10 | Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease:The Atherosclerosis Risk in Communities (ARIC) study显示文摘 | Lee CR North KE Bray MS | | 0，，10： | 1 |
| 11 | Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease : The Atherosclerosis Risk in Communities ( ARIC ) study 显示文摘 | Lee CR North KE Bray MS | 2006 | Hum Mol Genet2006，15，10： | 1 |
| 12 | Genetic variation in soluble epox- ide hydrolase (EPHX2) and risk of coronary heart disease: The Athero- sclerosis Risk in Communities ( ARIC ) study 显示文摘 | Lee CR North KE Bray MS | 2006 | Hum Mol Genet2006，15，10： | 1 |
| 13 | Site of infection rather than vancomycin MIC predicts vancomycin treatment failure in methicillin- resistant Staphylococcus aureus bacteraemia 显示文摘 | Walraven C J North MS Man' - Lyon L | 2011 | J Antimicrob Chemother2011，66，10： | 1 |
| 14 | Malignant tumors of the small intestine a review of 144 cases显示文摘 | North JH Pack MS | 2000 | Am Surg2000，66，： | 1 |
| 15 | Interferon beta-1b in secondary progressive MS:Results from a 3-year continUed study显示文摘 | The North American Study Group on interferon beta-lb in secondary progressive MS | 2004 | Neurology2004，63，： | 1 |
| 16 | An inconvenienced youth? Ageism and its potential intergenerational Roots显示文摘 | North MS Fiske ST | 2012 | Psychol Bull2012，138，5： | 1 |
| 17 | Cyclooxygenase polymorphisms and risk of cardiovascular events: The atherosclerosis risk in communities (ARIC) study显示文摘 | Lee CR North KE Bray MS | 2008 | Clin Pharmacol Ther2008，83，1： | 1 |
| 18 | Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease:The Atherosclerosis Risk in Communities (ARIC) study显示文摘 | Lee CR North KE Bray MS | 2006 | Hum Mol Genet2006，15，10： | 1 |
| 19 | Prognostic factors for adenocarcinoma of gallbladder:an analysis of 162 cases 显示文摘 | North JH Pack MS Hong C | 1998 | Am Surg1998，64，5： | 1 |
| 20 | Prognostic factors for adenocarcinoma of gallbladder:an analysis of 162 cases显示文摘 | PACK MS HONG C | 1998 | Am Surg1998，64，： | 1 |
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