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| 1 | Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis显示文摘AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations(variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis.METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI.RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality(OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites(OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed. | Jonathan G Stine Puja M Shah Scott L Cornella Sean R Rudnick Marwan S Ghabril George J Stukenborg Patrick G Northup | 2015 | World Journal of Hepatology2015，7，27： | 42 |
| 2 | Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis显示文摘 | Curtis K. Argo Patrick G. Northup Abdullah M.S. Al-Osaimi Stephen H. Caldwell | 2009 | Journal of Hepatology2009，，2： | 3 |
| 3 | Spontaneous bacterial peritonitis prevalence in pretransplant patients and its effect on survival and graft loss post-transplant显示文摘AIM To investigate the incidence of spontaneous bacterial peritonitis(SBP) in pre-transplant patients and its effect on post transplant mortality and graft failure. METHODS We conducted a retrospective cohort study of patient records from the organ procurement and transplant network data set. Patients were identified by the presence of SBP pre-transplant. Univariate post-transplant survival models were constructed using the Kaplan-Meier technique and multivariate models were constructed using the Cox proportional hazards model. Variables that affected post-transplant graft survival were identified in the SBP population. RESULTS Forty-seven thousand eight hundred and eighty patient records were included in the analysis for both groups, and 1966(4.11%) patients were identified in the data set as having pre-transplant SBP. Patients that had pre-transplant SBP had higher rates of graft loss from recurrent hepatitis C virus(HCV)(3.6% vs 2.0%, P < 0.0001), infections leading to graft loss(1.9% vs 1.3%, P = 0.02), primary non-function(4.3% vs 3.0%, P < 0.0001) and chronic rejection(1.1% vs 0.7%, P = 0.04). Kaplan-Meier survival analysis showed a statistically significant difference in all-cause survival in patients with a history of SBP vs those without(P < 0.0001). Pretransplant history of SBP was independently predictiveof mortality due to recurrent HCV(HR = 1.11, 95%CI: 1.02-1.21, P < 0.017) after liver transplantation.CONCLUSION HCV patients prior to the advent of directing acting anti-viral agents had a higher incidence of pre-transplant SBP than other patients on the liver transplant wait list. SBP history pre-transplant resulted in a higher rate of graft loss due to recurrent HCV infection and chronic rejection. | Neeral L Shah Nicolas M Intagliata Zachary H Henry Curtis K Argo Patrick G Northup | 2016 | World Journal of Hepatology2016，8，36： | 2 |
| 4 | Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis显示文摘AIM To examine if liver transplant recipients with high-risk non-alcoholic steatohepatitis(NASH) are at increased risk for pre-transplant portal venous thrombosis.METHODS Data on all liver transplants in the United States from February 2002 through September 2014 were analyzed. Recipients were sorted into three distinct groups: High-risk(age > 60, body mass index > 30 kg/m2, hypertension and diabetes), low-risk and non-NASH cirrhosis. Multivariable logistic regression models were constructed.RESULTS Thirty-five thousand and seventy-two candidates underwent liver transplantation and of those organ recipients, 465 were transplanted for high-risk and 2775 for lowrisk NASH. Two thousand six hundred and twentysix(7.5%) recipients had pre-transplant portal vein thrombosis; 66(14.2%) of the high-risk NASH group had portal vein thrombosis vs 328(11.8%) of the lowrisk NASH group. In general, all NASH recipients were less likely to be male or African American and more likely to be obese. In adjusted multivariable regression analyses, high-risk recipients had the greatest risk ofpre-transplant portal vein thrombosis with OR = 2.11(95%CI: 1.60-2.76, P < 0.001) when referenced to the non-NASH group.CONCLUSION Liver transplant candidates with high-risk NASH are at the greatest risk for portal vein thrombosis development prior to transplantation. These candidates may benefit from interventions to decrease their likelihood of clot formation and resultant downstream hepatic decompensating events. Prospective study is needed. | Jonathan G Stine Curtis K Argo Shawn J Pelletier Daniel G Maluf Stephen H Caldwell Patrick G Northup | 2017 | World Journal of Hepatology2017，9，3： | 2 |
| 5 | The guanine nucleotide activating site of the regulatory component of adenylate cyclase:Identification by ligand binding显示文摘 | Northup JK Smigel MD Gilman AG | | 0，，： | 1 |
| 6 | Do cytogenetic abnor malities precede morphological abnormalities in a develo- ping malignant condition显示文摘 | Northup JK Gadre SA Ge Y | 2007 | Eur J Haematol2007，78，2： | 1 |
| 7 | Calcium peroxide(CaO2) for use in modified Fenton显示文摘 | NORTHUP A CASSIDY D | 2008 | Journal of Hazardous Materials2008，152，3： | 1 |
| 8 | Systematic review of risk factors for fibrosisprogression in non-alcoholic steatohepatitis显示文摘 | Argo CK Northup PG Al-Osaimi AM | 2009 | J Hepatol2009，51，： | 1 |
| 9 | Polyph-enol control of nitrogen release from pine litter显示文摘 | Northup R R Yu Z Dahlgren R A | 1995 | Nature1995，377，2： | 1 |
| 10 | Polyphenol control of nitrogen release from pine litter显示文摘 | Northup RR Yu Z Dahlgren RA | 1995 | Nature1995，377，21： | 1 |
| 11 | Do cytogenetic abnor- malities precede morphological abnormalities in a develo- ping malignant condition显示文摘 | Northup JK Gadre SA Ge Y | 2007 | Eur J Haematol2007，78，2： | 1 |
| 12 | Hypercoagulation and thrombophilia in liver disease显示文摘 | Northup PG Sundaram V Fallon MB | 2008 | J Thromb Haemost2008，6，1： | 1 |
| 13 | Osteosarcoma associated with osteopoikilosis 显示文摘 | Mindell ER Northup CS Douglass HO Jr | 1978 | J Bone Joint Surg Am1978，60，3： | 1 |
| 14 | Coaguloparlay does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism显示文摘 | Northup PG McMahon MM Ruhl AP | 2006 | Am J Gastroenterol2006，101，7： | 1 |
| 15 | Evolution of soil properties sand plant communities along an edaphic gradient 显示文摘 | Yu Z Dahlgren R Northup R R | 1999 | Eur J Soil Biol1999，35，： | 1 |
| 16 | Determination of dissolved organic nitrogen using persulfate oxidation and conductimetric quantification of nitrate-nitrogen显示文摘 | Yu Z S Northup R R Dahlgren R A | 1994 | Commun Soil Sci Plant Anal1994，25，： | 1 |
| 17 | Polyphenols as regulators of plant-litter-soil interactions in northern California's pygmy forest: a positive feedback?显示文摘 | Northup R R Dahlgren R A McColl J G | 1998 | Biogeochemistry1998，42，12： | 1 |
| 18 | Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism 显示文摘 | Northup P G McMahon M M Ruhl A P | 2006 | Am J Gastroenterol2006，101，7： | 1 |
| 19 | Model for End- Stage Liver Disease (MELD) predicts nontransplant surgical mor- tality in patients with cirrhosis 显示文摘 | Northup PG Wananmker RC Lee VD | 2005 | Ann Surg2005，242，2： | 1 |
| 20 | Polyphenols as Regulators of Plant-litter-soil Interactions in Northern California’s Pygmy Forest: A Positive Feedback?显示文摘 | Robert R. Northup Randy A. Dahlgren John G. McColl | 1998 | Biogeochemistry (-)1998，，1： | 1 |
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