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| 1 | Molecular modulation of autophagy: New venture to target resistant cancer stem cells显示文摘Autophagy is a highly regulated catabolic process in which superfluous,damaged organelles and other cytoplasmic constituents are delivered to the lysosome for clearance and the generation of macromolecule substrates during basal or stressed conditions.Autophagy is a bimodal process with a context dependent role in the initiation and the development of cancers.For instance,autophagy provides an adaptive response to cancer stem cells to survive metabolic stresses,by influencing disease propagation via modulation of essential signaling pathways or by promoting resistance to chemotherapeutics.Autophagy has been implicated in a cross talk with apoptosis.Understanding the complex interactions provides an opportunity to improve cancer therapy and the clinical outcome for the cancer patients.In this review,we provide a comprehensive view on the current knowledge on autophagy and its role in cancer cells with a particular focus on cancer stem cell homeostasis. | Harpreet K Mandhair Miroslav Arambasic Urban Novak Ramin Radpour | 2020 | World Journal of Stem Cells2020，12，5： | 2 |
| 2 | On Geoid Determination from Airborne Gravity显示文摘 | Novak P Kern M Schwarz K P | 2003 | Journal of Geodesy2003，76，： | 1 |
| 3 | Principles of the hydrolysis assisted solidification (HAS)process for forming ceramic bodies from aqueous suspensions显示文摘 | Novak S Kosmac T Krnel K | 2002 | J Eur Ceram Soc2002，，2： | 1 |
| 4 | Pseudoglandular myxoid adenoma of the adrenal gland显示文摘 | Dundr P Novak K | 2003 | Pathol Res Pract2003，199，7： | 1 |
| 5 | Evaluation of Band-Limited Topographical Effects in Airborne Gravimetry显示文摘 | Novak P Kern M Schwarz K P | 2003 | Journal of Geodesy2003，76，： | 1 |
| 6 | Spontaneous reversion of the angiogenic phenotype to a nonanglogenic and dormant state in human tumors显示文摘 | Rogers MS Novak K Zurakowski D | 2014 | Mol Cancer Res2014，12，5： | 1 |
| 7 | Epigenetic regulation of autophagy: A key modification in cancer cells and cancer stem cells显示文摘Aberrant epigenetic alterations play a decisive role in cancer initiation and propagation via the regulation of key tumor suppressor genes and oncogenes or by modulation of essential signaling pathways.Autophagy is a highly regulated mechanism required for the recycling and degradation of surplus and damaged cytoplasmic constituents in a lysosome dependent manner.In cancer,autophagy has a divergent role.For instance,autophagy elicits tumor promoting functions by facilitating metabolic adaption and plasticity in cancer stem cells(CSCs)and cancer cells.Moreover,autophagy exerts pro-survival mechanisms to these cancerous cells by influencing survival,dormancy,immunosurveillance,invasion,metastasis,and resistance to anti-cancer therapies.In addition,recent studies have demonstrated that various tumor suppressor genes and oncogenes involved in autophagy,are tightly regulated via different epigenetic modifications,such as DNA methylation,histone modifications and non-coding RNAs.The impact of epigenetic regulation of autophagy in cancer cells and CSCs is not wellunderstood.Therefore,uncovering the complex mechanism of epigenetic regulation of autophagy provides an opportunity to improve and discover novel cancer therapeutics.Subsequently,this would aid in improving clinical outcome for cancer patients.In this review,we provide a comprehensive overview of the existing knowledge available on epigenetic regulation of autophagy and its importance in the maintenance and homeostasis of CSCs and cancer cells. | Harpreet K Mandhair Urban Novak Ramin Radpour | 2021 | World Journal of Stem Cells2021，13，6： | 1 |
| 8 | Macroelectronic applications of carbon nanotube networks 显示文摘 | Novak J P Lay M D Perkins F K | 2004 | Solid - State Ele2004，48，10： | 1 |
| 9 | The genetics and immunobiology of IgA nephropathy 显示文摘 | Kiryluk K Novak J | 2014 | The Journal of Clinical Investigation2014，124，6： | 1 |
| 10 | Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination显示文摘 | Lole K S Bollinger R C Paranjape R S Novak N G | 1999 | J Virol1999，73，： | 1 |
| 11 | Animal management to reduce phosphorus losses to the environment显示文摘 | Knowhon K F Radcliffe J S Novak C L | 2004 | J Anim Sci2004，82，： | 1 |
| 12 | Salt effect on the separation by hydrophilie membranes显示文摘 | Majewska - Novak K Kabsch - Korbutowicz M Winnicki W | 1996 | Desalination1996，108，： | 1 |
| 13 | Transplantation of cryopreserved osteochondral Dowel allografts for repair of focal articular defects in an ovine model显示文摘 | Schachar NS Novak K Hurtig M | 1999 | J Orthop Res1999，17，6： | 1 |
| 14 | Impact of biochar amend- ment on fertility of a southeastern coastal plain soil显示文摘 | Novak K M Busscher W J Laild D L | 2009 | Soil Science2009，174，： | 1 |
| 15 | Effects of refrigeration or freezing on survival of Listeria monocytogenes Scott A in under-cooked ground beef显示文摘 | NOVAK J S JUNEJA V K | 2003 | Food Control2003，14，1： | 1 |
| 16 | Should Immunonutrifion Become Routine in Critically ill Patients? A Systematic Review of the Evidence显示文摘 | Heyland D K Novak F Drover J W | 2001 | J AMA2001，286，8： | 1 |
| 17 | Low-dose/high-concentration localized Botulinum toxin A improves upper limb movement and function in children with hemiplegic cerebral palsy 显示文摘 | Lowe K Novak I Cusick A | 2006 | Dev Med Child Neurol2006，48，3： | 1 |
| 18 | A novel in situ technology for the treatment of nitrate contaminated groundwa ter显示文摘 | Haugen K S Semmens M J Novak P J | 2002 | Water Research2002，36，： | 1 |
| 19 | Repeat injection of Botulinum toxin A is safe and effective for upper limb movement and func- tion in children with cerebral palsy 显示文摘 | Lowe K Novak I Cusick A | 2007 | Dev Med Child Neurol2007，49，11： | 1 |
| 20 | The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression 显示文摘 | KIM S K NOVAK R F | 2007 | Pharmacol Ther2007，113，1： | 1 |
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