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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Viscoelastic properties of reduced-fat and full-fat cheddar cheeses显示文摘 | MA L DRAKE M A BARBOSA-C /NOVAS G V | 1996 | Journal of Food Science1996，61，4： | 1 |
| 3 | The chemistry of the NO/NO2-NH3 'fast' SCR reaction over Fe-ZSM-5 investigated by transient reaction analysis 显示文摘 | GROSSALE A NOVA I TRONCONI E CHATTERJEE D WEIBEL M | 2008 | J Catal2008，256，2： | 1 |
| 4 | Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus 显示文摘 | RODRIGUES D C TABA M J NOVAES A B | 2003 | J Periodontal2003，74，9： | 1 |
| 5 | Ammonium assimilation and amino acid metabolism in conifers显示文摘 | Cánovas F M Avila C Cantón F R Caňas R A Torre F | 2007 | Journal of Experimental Botany2007，58，9： | 1 |
| 6 | Influence of Implant Microstructure on the Dynamics of Bone Healing Around Immediate Implants Placed into Periodontally Infected Sites显示文摘 | PAPALEXIOU V NOVAES A B GRISE M F M | 2004 | Clinical Oral Implants Research2004，15，1： | 1 |
| 7 | Selective activation of the ortho C--F bond in pentafluoropyridine by zerovalent nickel: Reaction via a metallophosphorane intermediate stabilized by neighboring group assistance from the pyridyl nitrogen显示文摘 | Nova A Reinhold M Perutz R N | 2010 | Organometallics2010，29，： | 1 |
| 8 | Stressors inICU : perception of the patient,relatives and health-careteam显示文摘 | Novaes M A Knobel E Bork A M | 1999 | Int Care Med1999，25，12： | 1 |
| 9 | Association between ambient air pollution and birth weight in S? o Paulo, Brazil 显示文摘 | GOUVEIA N BREMNER S A NOVAES H M D | 2004 | J Epidemiol Community Health2004，58，： | 1 |
| 10 | Noise and vibration reduction for small/medium car market segment:an innovative approach for engineering design and manufacturing显示文摘 | NOVA M TAMBURRO A | 1997 | Automotive Vehicle Technologies1997，51，3： | 1 |
| 11 | Using ISO 25040 Standard for Evaluating Electronic Health Record Systems显示文摘 | Oliveira M Novaes M Vasconcelos A | | 0，，： | 1 |
| 12 | Association between ambient air pollution and birth weight in Sao Paulo,Brazil显示文摘 | Gouveia N Bremner S A Novaes H M D | 2004 | J Epidemiol Community Health2004，58，： | 1 |
| 13 | FTIR in situ mechanistic study of the NH3NO/NO2 'Fast SCR' reaction over a commercial Fe-ZSM-5 catalyst显示文摘 | Ruggeri M P Grossale A Nova I | 2011 | Corrected Proof2011，，20： | 1 |
| 14 | Elastic -plastic model for cemented soils 显示文摘 | Vatsala A Nova R Srinivasa M B R | 2001 | Journal of Geotechnical and Geoenvironment Engineering2001，127，8： | 1 |
| 15 | Quantification of imatinib in human serum:validation of a high-performance liquid chromatography-mass spectrometry method for therapeutic drug monitoring and pharmacokinetic assays显示文摘 | Rezende V M Rivellis A Novaes M M | 2013 | Drug Design Development and Therapy2013，7，： | 1 |
| 16 | Stressors in ICU: patients evaluation显示文摘 | Novaes M Aronovich A Ferraz MB | 1997 | Intensive Care Med1997，23，6： | 1 |
| 17 | The effect of immobi-lization/mobilization processes on the temperature onset of a cat-alyst bed production studied with ethylene oligomerization on FIZSM-5 zeolites显示文摘 | Zika'nova'A Derewin'sk M Sarv P | 2006 | Catalysis2006，，114： | 1 |
| 18 | Ferroelectric phase transitions in ionic conductors based on bismuth vadanate显示文摘 | Politova E D Fortal'nova E A Kaleva G M | 2009 | Physics of the Solid State2009，51，7： | 1 |
| 19 | Tennis, incidence of URTI and salivary IgA显示文摘 | Novas A M P Rowbottom D G Jenkins D G | 2003 | Int J Sports Med2003，24，： | 1 |
| 20 | Elasto-plastic model for cemented soils显示文摘 | Vatsala A Nova R Srinivasa M B R | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，8： | 1 |
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