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| 1 | Soft drinks consumption and nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is a common clinical condition which is associated with metabolic syndrome in 70% of cases.Inappropriate dietary fat intake,excessive intake of soft drinks,insulin resistance and increased oxidative stress combine to increase free fatty acid delivery to the liver,and increased hepatic triglyceride accumulation contributes to fatty liver.Regular soft drinks have high fructose corn syrup which contains basic sugar building blocks,fructose 55% and glucose 45%.Soft drinks are the leading source of added sugar worldwide,and have been linked to obesity,diabetes,and metabolic syndrome.The consumption of soft drinks can increase the prevalence of NAFLD independently of metabolic syndrome.During regular soft drinks consumption,fat accumulates in the liver by the primary effect of fructose which increases lipogenesis,and in the case of diet soft drinks,by the additional contribution of aspartame sweetener and caramel colorant which are rich in advanced glycation end products that potentially increase insulin resistance and inflammation.This review emphasizes some hard facts about soft drinks,reviews fructose metabolism,and explains how fructose contributes to the development of obesity,diabetes,metabolic syndrome,and NAFLD. | William Nseir Fares Nassar Nimer Assy | 2010 | World Journal of Gastroenterology2010，16，21： | 20 |
| 2 | Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance显示文摘AIM: To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance. METHODS: Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneousHBsAg seroclearance.HBsAg seroclearance. RESULTS: Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (>35 years) OR = 1.7 (95%CI: 1.25-2.8, P=0.05), serum vitamin D levels (>20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P=0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P=0.02), low viral load (hepatitis B virus DNA < 100 IU/mL) OR = 3 (95%CI: 2.6-4.2, P = 0.01) and duration of HBsAg seropositivity (> 8 years) OR = 1.6 (95%CI: 1.15-2.6, P=0.04) were also associated with spontaneous HBsAg seroclearance. CONCLUSION: We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance. | Mahmud Mahamid William Nseir Omar Abu Elhija Shimon Shteingart Ammad Mahamid Mosab Smamra Benjamin Koslowsky | 2013 | World Journal of Hepatology2013，5，6： | 14 |
| 3 | Role of diet and lifestyle changes in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)has becomeone of the most common causes of liver disease worldwide and has been recognized as a major health burden.The prevalence of NAFLD has grown proportionallywith the rise in obesity,sedentary lifestyle,unhealthydietary pattern,and metabolic syndrome.Currently,there is no drug therapy that can be formulated fortreating NAFLD.A combination of dietary modificationsand increased physical activity remains the mainstayof NAFLD management.It is hard to maintain thismode of management;however,it seems to havesignificant long-term benefits.Furthermore,NAFLDpatients,whether obese or not,should be educatedthat a healthy diet and physical activity have benefitsbeyond weight reduction.Further large controlled randomized trials are needed in order to identify the bestdietary regimen and physical activity in the management of NAFLD patients.This review highlights the roleof diet and lifestyle modifications in the managementof NAFLD,and focuses on human studies regarding dietary modifications and physical activity. | William Nseir Elias Hellou Nimer Assy | 2014 | World Journal of Gastroenterology2014，20，28： | 9 |
| 4 | Lower baseline ALT cut-off values and HBV DNA levels better differentiate HBeAg(-) chronic hepatitis B patients from inactive chronic carriers显示文摘AIM:To determine whether new cut-off values for alanine aminotransferase(ALT)and baseline hepatitis B virus(HBV)DNA levels better differentiate HBeAg(-) chronic hepatitis B(CHB)patients from inactive chronic carriers. METHODS:Ninety-one patients[32 HBeAg(+)CHB, 19 inactive carriers and 40 HBeAg(-)CHB]were followed up for 2 years and were tested for HBV DNA levels by a PCR-based assay.ALT was tested twice during the last 6 mo using new cut-off values:ULN(upper limit of normal)30 IU/L for males,19 IU/L for females. Diagnostic accuracy,sensitivity,specificity,positive and negative predictive values were calculated by discriminant analysis. RESULTS:When using the revised ALT cut-off values, the lowest optimal HBV DNA level that differentiated HBeAg(-)CHB patients from inactive carriers was 50000 copies/mL.The diagnostic accuracy of HBV DNA to determine inactive carriers with a cut-off of 50000 copies/mL was similar to the previously recommended cut-off of 100 000 copies/mL(91%).HBV DNA levels were lower than the cut-off value in 95%of inactive carriers and in 28%of HBeAg(-)CHB patients.With ALT<30 IU/L in men and<19 IU/L in women and HBV DNA levels<100 000 copies/mL,the risk of CHB is 5%.On the other hand,if ALT values were>30 IU in men and>19 IU in women and baseline HBV DNA levels were>100000 copies/mL,the risk is 86%. CONCLUSION:New cut-off values for ALT together with HBV DNA levels proposed by AASLD(American Association for the Study of Liver Diseases)and NIH (National Institute of Health)consensus seem appropriate to characterize inactive carriers. | Nimer Assy Zaza Beniashvili Agness Djibre Gattas Nasser Maria Grosovski William Nseir | 2009 | World Journal of Gastroenterology2009，15，24： | 7 |
| 5 | Lipid-Lowering Agents in Nonalcoholic Fatty Liver Disease and Steatohepatitis: Human Studies显示文摘 | William Nseir Julnar Mograbi Murad Ghali | 2012 | Digestive Diseases and Sciences2012，，7： | 2 |
| 6 | Intensive care unit-acquired Stenotrophomonas maltophilia:incidence,risk factors,and outcome显示文摘 | Nseir S Di Pompeo C Brisson H | 2006 | Crit Care2006，10，5： | 1 |
| 7 | First-generation fluoroquinolone use and subsequent emergence of multiple drug-resistant bacteria in the intensive care unit显示文摘 | Nseir S Di Pompeo C Soubrier S | 2005 | Crit Care Med2005，33，： | 1 |
| 8 | Long-tema stalin therapy affects the severity of chronic gaslritis显示文摘 | Nseir W Khateeb J Tatour I | 2010 | Helicobacter2010，15，6： | 1 |
| 9 | Accuracy of American Thoracic Society/Infectious Diseases Society of America criteria in predicting infection or colonization with multidrug- resistant bacteria at intensive-care unit admission 显示文摘 | Nseir S Grailles G Soury-Lavergne A | 2010 | Clin Microbiol Infect2010，16，7： | 1 |
| 10 | The impact of prior long-term versus short-tema stalin use on the mortality of bacteraemic patients显示文摘 | Nseir W Mograbi J Abu-Elheja O | 2012 | Infection2012，40，1： | 1 |
| 11 | Acute invasive pulmonary aspergillosis in chroniclung disease-a review显示文摘 | Ader F Nseir S Guery B | 2006 | Rev Mai Respir2006，23，： | 1 |
| 12 | Multiple-drug-resistant bacteria in patients with severe acute exacerbation of chronic obstructive pulmonary disease:Prevalence,risk factors,and outcome显示文摘 | Nseir S Di PC Cavestri B | 2006 | Crit Care Med2006，34，： | 1 |
| 13 | Continuous control of tracheal cuff pressure for the prevention of ventilator-associated pneumonia in critically ill patients:where is the evidence显示文摘 | RouzéA Nseir S | 2013 | Curr Opin Crit Care2013，19，5： | 1 |
| 14 | Multiple-drug-resistant bacte- ria inpatients with severe acute exacerbation of chronic obstructive pul- monary disease: prevalence, risk factors, and outcome 显示文摘 | Nseir S Di Pompeo C Cavestri B | 2006 | Crit Care Med2006，12，： | 1 |
| 15 | Diagnosis of hospital -acquired pneumonia: postmortem studies显示文摘 | Nseir S Marquette CH | 2003 | Infect Dis Clin North Am2003，17，： | 1 |
| 16 | Invasive pulmonary as- pergillosis in chronic obstructive pulmonary disease: an e- merging fungalpathogen 显示文摘 | Ader F Nseir S Le Berre R | 2005 | Clin Microbiol Infect2005，11，6： | 1 |
| 17 | Continuous control of tracheal cuff pressure and microaspiration of gastric contents in critically ill patients显示文摘 | Nseir S Zerimech F Fournier C | 2011 | Am J Respir Crit Care Med2011，184，10： | 1 |
| 18 | Intensive care unit-acquired infection as a side effect of sedation 显示文摘 | Nseir S Makris D Mathieu D | 2010 | Crit Care2010，14，2： | 1 |
| 19 | Nosocomial tracheobronchitis in mechanically ventilated patient: incidence, aetiology and outcome 显示文摘 | Nseir S Di Propeo C Pronnier P | 2002 | Eur Respir J2002，1，20： | 1 |
| 20 | Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome显示文摘 | Ali Abid Ola Taha William Nseir Raymond Farah Maria Grosovski Nimer Assy | 2009 | Journal of Hepatology2009，，5： | 1 |
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