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| 1 | Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults显示文摘BACKGROUND Shifting on lifestyle,diet,and physical activity contributed on increasing number of obese people around the world.Multiple factors influence the development of obesity.Some research suggested that gut microbiota(GM)plays an important role in nutrient absorption and energy regulation of individuals,thus affecting their nutritional status.Report of Indonesia Basic Health Research showed that the prevalence of obesity in every province tended to increase.Although the root cause of obesity is excessive calorie intake compared with expenditure,the differences in gut microbial ecology between healthy and obese humans may affect energy homeostasis.GM affect body weight,especially obesity.Probiotics that are consumed while alive and able to colonize in the intestine are expected to increase the population of good bacteria,especially Bifidobacteria and Lactobacilli,and suppress pathogens such as Enterobacteriaceae and Staphylococcus.The strain of L.plantarum Dad-13 has been demonstrated to survive and colonize in the gastrointestinal tract of healthy Indonesian adults who consume fermented milk containing L.plantarum Dad-13.The consumption of probiotic L.plantarum Dad-13 powder decreased E.coli and non-E.coli coliform bacteria in school-aged children in Indonesia.L.plantarum is a dominant bacterium in the average Indonesian’s GM.For this reason,this bacterium is probably a more suitable probiotic for Indonesians.AIM To determine the effect of the consumption of indigenous probiotic Lactobacillus plantarum Dad-13 powder in overweight adults in Yogyakarta(Indonesia).METHODS Sixty overweight volunteers with a body mass index(BMI)equal to or greater than 25 consume indigenous probiotic powder L.plantarum Dad-13(2×109 CFU/gram/sachet)for 90 d.The study was a randomized,double-blind,placebocontrolled study.The volunteers filled in a diary on a daily basis,which consisted of questions on study product intake(only during ingestion period),other food intake,number of bowel movements,fecal quality(consistency and color),any medications received,and any symptom of discomfort,such as diarrhea,constipation,vomiting,gassing,sensation of illness,etc.Fecal samples and the subjects’diaries were collected on the morning of day 10+1,which was marked as the end of the baseline period and the start of the ingestion period.During the ingestion period(from day 11 to day 101),several parameters to measure and analyze the results included body weight and height(once a month),the lipid profile,GM analysis using MiSeq,short-chain fatty acid(SCFA)analysis using gas chromatography,and the measurement of fecal pH using a pH meter.RESULTS The consumption of indigenous probiotic powder L.plantarum Dad-13 caused the average body weight and BMI of the probiotic group to decrease from 84.54±17.64 kg to 83.14±14.71 kg and 33.10±6.15 kg/m2 to 32.57±5.01 kg/m2,respectively.No significant reduction of body weight and BMI in the placebo group was observed.An analysis of the microbiota showed that the number of Bacteroidetes,specifically Prevotella,increased significantly,while that of Firmicutes significantly decreased.No significant change in lipid profile in both groups was found.Also,no significant change in SCFAs(e.g.,butyrate,propionate,acetic acid)and pH level was found after the consumption of the probiotic.CONCLUSION No significant differences in pH before and after ingestion were observed in both the probiotic and placebo groups as well as in the lipid profile of both cholesterol and triglyceride,high-density lipoprotein(HDL),low-density lipoprotein(LDL),and the LDL/HDL ratio.In addition,no significant changes in the concentration of SCFAs(e.g.,acetic acid,propionate,and butyrate)were found after consumption.Interestingly,a significant decrease in body weight and BMI(P<0.05)was determined in the treatment group.An analysis of GM shows that L.plantarum Dad-13 caused the Firmicutes population to decrease and the Bacteroidetes population(especially Prevotella)to increase. | Endang Sutriswati Rahayu Mariyatun Mariyatun Nancy Eka Putri Manurung Pratama Nur Hasan Phatthanaphong Therdtatha Riko Mishima Husnita Komalasari Nurul Ain Mahfuzah Fathyah Hanum Pamungkaningtyas Wahyu Krisna Yoga Dina Aulia Nurfiana Stefanie Yolanda Liwan Mohammad Juffrie Agung Endro Nugroho Tyas Utami | 2021 | World Journal of Gastroenterology2021，27，1： | 6 |
| 2 | 管线直接铺设技术显示文摘管线直接铺设技术借助“管道推进器”(Pipe Thruster)的连续推进,单向连续地将预制管线铺设到位。如同顶管法一样,土体挖掘作业仍通过与管线相连的微型隧道掘进机来完成,开挖面通过泥浆维持,通常用膨润土泥浆。由于新方法的成功,已在几个工程中得以应用。管道推进器所产生的推力是直接铺管工程设计时考虑的一个重要M题。本文利用ABAQUS软件包里的有限元法分析了将管线推入钻孔时所需要的力及相关因素。对有限元法计算结果的分析表明这几种因素之间具有强烈的相互影响。而且,根据这些因素和管段受力分析得出了推力计算公式,并将最近几个工程中测量出的推进力与根据这些计算公式的计算值进行了对比。结果袁明,摩擦系数E和￡应分别取为100Pa和0.3,推力设计值应将计算出的推力值乘以1.5倍的安全系数。这个安全系数主要是考虑到在停顿期会有2.5%的概率超过上述计算值后提出的。 | Pruiksma J. D. Pfeff D. Nugroho R.P. Boeije H.M.G. Kruse 张健 万谦 | 2013 | 非开挖技术2013，，2： | 6 |
| 3 | Hesperidin as a preventive resistance agent in MCF-7 breast cancer cells line resistance to doxorubicin显示文摘Objective:To evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant doxorubicin cells(MCF-7/Dox)in cytotoxicity apoptosis and P-glycoprotein(Pgp)expression in combination with doxorubicin.Methods:The cytotoxic properties.50%inhibition concentration(IC_(50))and its combination with doxorubicin in MCF-7 cell lines resistant to doxorubicin(MCF-7/Dox)cells were determined using MTT assay.Apoptosis induction was examined by double staining assay using ethidium bromide-acridine orange.Immunocytochemistry assay was performed to determine the level and localization of Pgp.Results:Single treatment of hesperidin showed cytotoxic activity on MCF-7/Dox cells with IC_(50)value of 11μmol/L.Thus,combination treatment from hesperidin and doxorubicin showed addictive and antagonist effect(CI>1.0).Hesperidin did not increase the apoptotic induction,but decreased the Pgp expressions level when combined with doxorubicin in low concentration.Conclusions:Hesperidin has cytotoxic effect on MCF-7/Dox cells with IC_(50)of 11μmol/L.Hesperidin did not increased the apoptotic induction combined with doxorubicin.Cochemotherapy application of doxorubicin and hesperidin on MCF-7/Dox cells showed synergism effect through inhibition of Pgp expression. | Rifki Febriansah Dyaningtyas Dewi P.P. Sarmoko Nunuk Aries Nurulita Edy Meiyanto Agung Endro Nugroho | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，3： | 5 |
| 4 | 富虾青素玉米对蛋鸡生产性能、抗氧化能力、虾青素富集及蛋品质的影响显示文摘试验旨在研究富虾青素玉米对蛋鸡生产性能、抗氧化能力、虾青素富集及蛋品质的影响。选用28周龄海兰褐蛋鸡270只,分为3组,每组6重复,每重复15只鸡。对照组饲喂玉米-豆粕型饲粮,虾青素组在饲粮中添加虾青素24.32 mg/kg(计算值),富虾青素玉米组采用富虾青素玉米配制饲粮,饲粮虾青素含量为24.32 mg/kg(计算值)。预试1周,正试期8周。结果表明:虾青素和富虾青素玉米均可降低蛋鸡日采食量(P<0.05),提高蛋黄颜色a*值,并降低L*和b*值(P<0.05);虾青素和富虾青素玉米组鸡蛋中虾青素含量和富集效率均无显著差异,富虾青素玉米组蛋黄玉米黄质低于其他两组(P<0.05);与对照组相比,虾青素及富虾青素玉米组血清超氧化物歧化酶具有升高趋势(P=0.098),丙二醛含量降低(P<0.05)。在本试验条件下,蛋鸡饲粮使用富虾青素玉米可与添加虾青素发挥同等营养作用,均可改善蛋鸡生产性能,提高蛋黄颜色,增强机体抗氧化能力并使蛋黄富集虾青素。 | Ramdhan Dwi NUGROHO DieudonnéMahukpégo DANSOU 王浩 贺维朝 张军民 汤超华 赵青余 秦玉昌 | 2022 | 中国畜牧杂志2022，58，9： | 4 |
| 5 | Comparison of the morphology and structure of W03 nanomaterials synthesized by a sol-gel method followed by calcination^or hydrothermal treatment显示文摘 | Diah Susanti Stefanus Haryo N Hasnan Nisfu Eko Prasetio Nugroho Hariyati Purwaningsih GeorgeEndri Kusuma Shao-Ju Shih | 2012 | Frontiers of Chemical Science and Engineering2012，6，4： | 3 |
| 6 | OsSCE1 Encoding SUMO E2-Conjugating Enzyme Involves in Drought Stress Response of Oryza sativa显示文摘Small ubiquitin-like modifier(SUMO)-conjugating enzymes are involved in post-translational regulatory processes in eukaryotes, including the conjugation of SUMO peptides to protein substrate(SUMOylation). SUMOylation plays an important role in improving plant tolerance to abiotic stress such as salt, drought, heat and cold. Herein, we reported the isolation of OsSCE1(LOC_Os10 g39120) gene encoding a SUMO-conjugating enzyme from rice(Oryza sativa cv. Nipponbare) and its functional validation in response to drought stress. The E2 enzyme, Os SCE1, is one of three key enzymes involved in the conjugation of SUMO to its target proteins. Activated SUMO is transferred to the cysteine of an E2 enzyme and then to the target lysine residue of the substrate, with or without the help of an E3 SUMO ligase. Expression of OsSCE1 was strongly induced by polyethylene glycol 6000(PEG6000) treatment, which suggested OsSCE1 may be involved in the drought stress response. Overexpression of OsSCE1(OsSCE1-OX) in Nipponbare reduced the tolerance to drought stress. Conversely, the drought tolerance was slightly improved by the knockdown of OsSCE1(OsSCE1-KD). These results were further supported by measurement of proline content in OsSCE1-OX and OsSCE1-KD transgenic lines under induced drought stress, which showed OsSCE1-KD transgenic lines accumulated higher proline content than the wild type, whereas OsSCE1-OX line had lower proline content than the wild type. These findings suggested OsSCE1 may play a role as a negative regulator in response to drought stress in rice. | Dini NURDIANI Dwi WIDYAJAYANTIE Satya NUGROHO | 2018 | Rice science2018，25，2： | 2 |
| 7 | Franchise ownership redirection:real options perspective显示文摘Background:For over 40 years,the franchise ownership redirection hypothesis has attracted the attention of many scholars.This study,differing from previous ones,proposes an alternative approach for this hypothesis using a real options framework with the extension of agency theory.Method:The real options model is built using the least square Monte Carlo method,where the franchisor’s decision to franchise is perceived as a deferred investment while maintaining the right of future acquisition.Result:Tested using monte carlo simulation based hypothetical case,the model shows a different result from classical real options call model.This is mainly due to franchise contractual arrangement,where royalty fee lower the threshold of acquisition cost in converting the franchise outlet to company owned.Conclusion:The aim of this study is to create an analytical framework that helps a franchisor decide whether or not toacquire and convert a franchise unit to a company-owned unit at a certain point in time,analyzing the choice as a deferment of investment.The franchisors that faces the opportunity to optimize profit by converting the franchise unit to a company-owned unit should acknowledge it as real options thus negotiate the terms with their franchisees. | Lukito Adi Nugroho | 2016 | Financial Innovation2016，2，1： | 2 |
| 8 | The Use of Single-Phase Immersion Cooling by Using Two Types of Dielectric Fluid for Data Center Energy Savings显示文摘Data centers are recognized as one of the most important aspects of the fourth industrial revolution since conventional data centers are inefficient and have dependency on high energy consumption,in which the cooling is responsible for 40%of the usage.Therefore,this research proposes the immersion cooling method to solving the high energy consumption of data centers by cooling its component using two types of dielectric fluids.Four stages of experimentalmethods are used,such as fluid types,cooling effectiveness,optimization,and durability.Furthermore,benchmark software is used to measure the CPU maximum work with the temperature data performed for 24 h.The results of this study show that the immersion cooling reduces 13℃ lower temperature than the conventional cooling method which means it saves more energy consumption in the data center.The most optimum variable used to decrease the temperature is 1.5 lpm of flow rate and 800 rpm of fan rotation.Furthermore,the cooling performance of the dielectric fluids shows that the mineral oil(MO)is better than the virgin coconut oil(VCO).In durability experiment,there are no components damage after five months immersed in the fluid. | Nugroho Agung Pambudi Awibi Muhamad Yusuf Alfan Sarifudin | 2022 | Energy Engineering2022，119，1： | 2 |
| 9 | In vivo sedative and gastropro- tective activities of Salvia plebeia extract and its composition of poly- phenols显示文摘 | Nugroho A Kim MH Choi J | 2012 | Archives of Pharmaeal Research2012，35，8： | 1 |
| 10 | Litterfall and soil characteristics under plantations of five tree species in Irian Jaya显示文摘 | Nugroho J D | 1997 | Sci New Guinea1997，23，： | 1 |
| 11 | Tectonic controls on the hydrocarbon habitats of the Barito, Kutei, and Tarakan Basins, Eastern Kalimantan, Indonesia: major dissimilarities in adjoining basins显示文摘 | Awang Harun Satyana Djoko Nugroho lmanhardjo Surantoko | 1999 | Journal of Asian Earth Sciences1999，17，12： | 1 |
| 12 | Degradation of poly( L-lactic acid) by γ-irradiation显示文摘 | Pramono Nugroho Hiroshi Mitomo Fumio Yoshii | 2001 | Polymer Degradation and Stability2001，72，： | 1 |
| 13 | Degradation of poly(L-lactic acid) by γ-irradiation显示文摘 | Pramono Nugroho Hiroshi Mitomo Fumio Yoshii | 2001 | Polymer Degradation and Stability2001，72，： | 1 |
| 14 | Deep vein thrombosis in elderly patients following surgery for fracture of the proximal femur显示文摘 | Magetsari R Dewo P Nugroho AS | 2014 | Malays Orthop2014，8，： | 1 |
| 15 | Characterization of K,O/CaO-ZnO Catalyst for Transesterification of Soy?bean Oil to Biodiesel显示文摘 | Istadi 1 Prasetyo S A Nugroho T S | 2015 | Procedia Environmental Sci?ences2015，23，： | 1 |
| 16 | Identification and quantification of flavonoids in Carica papaya leaf and peroxynitrite-scavenging activity显示文摘Objective: To characterize the types, contents, and peroxynitrite-scavenging activities of flavonoids in the leaf of Carica papaya(C. papaya).Methods: Chromatographic and spectroscopic techniques along with high performance liquid chromatography quantitative analysis and peroxynitrite-scavenging assay were performed to isolate and quantify flavonoid compounds in the flavonoid-rich fraction(Bu OH fraction) derived from Me OH extract of C. papaya leaves and evaluate their peroxynitrite-scavenging activities.Results: Seven flavonoids were isolated from the leaves of C. papaya, including quercetin 3-(2~G-rhamnosylrutinoside), kaempferol 3-(2~G-rhamnosylrutinoside), quercetin 3-rutinoside, myricetin 3-rhamnoside, kaempferol 3-rutinoside, quercetin, and kaempferol. All of the substances exhibited potent activities on peroxynitrite scavenging(IC50 4.15 mmol/L), which were stronger than the positive control, L-penicillamine(6.90 mmol/L). The content of kaempferol 3-(2~G-rhamnosylrutinoside) was significantly higher than other identified compounds(123.18 mg/g Bu OH fraction and 7.23 mg/g Me OH extract).Conclusions: The results of the present study demonstrate the potent antioxidant flavonoids of C. papaya leaf, with kaempferol 3-(2~G-rhamnosylrutinoside) as the major one. | Agung Nugroho Hesty Heryani Jae Sue Choi Hee-Juhn Park | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 1 |
| 17 | Is accumulation of sesquiterpenoid phytoalexin induced in tobacco plants constitutively producing salicylic acid? 显示文摘 | Nugroho L H Peltenburg-Looman A M G Verberne M C | 2002 | Plant Sci2002，162，： | 1 |
| 18 | Low-temperature of Single and Blended Coals显示文摘 | Nugroho Y S Mclntosh A C Gibbs B M | 2000 | Fuel2000，79，： | 1 |
| 19 | Tectonic controls on thehydrocarbon habitats of the Barito,Kutei,and Tarakan Basins,Eastern Kalimantan,Indonesia:Major dissimilarities in adjoiningbasins显示文摘 | Satyana A H Nugroho D Surantoko I | 1999 | Journal of Asian Earth Sciences1999，17，12： | 1 |
| 20 | Metallothionein-bound cadmium in the gut of the insect Orchesella cincta (Collembola) in relation to dietary cadmium exposure显示文摘 | Paul J Hensbergen Martin J.M van Velzen Rully Adi Nugroho Marianne H Donker Nico M van Straalen | 2000 | Comparative Biochemistry and Physiology Part C: Comparative Pharmacology and Toxicology2000，，1： | 1 |
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