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| 1 | Association of ezrin expression in intestinal and diffuse gastric carcinoma with clinicopathological parameters and tumor type显示文摘AIM: To investigate the correlation between ezrin expression and types of gastric carcinoma and clinicopathological variables. METHODS: We examined ezrin protein expression in 75 gastric carcinoma (53 intestinal types of adenocarcinoma, 22 diffuse types of carcinoma) tissues by immunohistochemistry. The results were compared with clinicopathological parameters such as tumor type, grade of tumor, clinical stage, presence of metastatic lymph node, and depth of invasion. RESULTS: Ezrin immunostaining was positive in 43 cases (81.1%) of intestinal type and in 9 (40.9%) cases of diffuse type adenocarcinomas (P < 0.001). In gastric carcinomas, the expression of ezrin protein correlated with the status of H pylori and survival. There was no correlation between expression of ezrin with TNM stage and histological grade of gastric carcinomas (P > 0.05). CONCLUSION: The low expression of ezrin implicates the loss of adhesion in diffuse carcinomas. Furthermore, overexpression of ezrin in carcinomas with H pylori infection may be a genuine specific pathway in which H pylori may cause/initiate gastric carcinoma. | Nebil Bal Sedat Yildirim Tarik Z Nursal Filiz Bolat Fazilet Kayaseluk | 2007 | World Journal of Gastroenterology2007，13，27： | 9 |
| 2 | Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment显示文摘AIM: To assess the antioxidant and antifibrotic effects of long-term Ginkgo biloba administration on liver fibrosis induced by biliary obstruction in rats.METHODS: Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL). Ginkgo administered for 28 d. At the end of the treatment period,all rats were killed. Serum aspartate aminotransferase (AST),alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined to assess liver functions and tissue damage, respectively. Tumor necrosis factor-α (TNF-α) was also assayed in serum samples. Liver tissues were taken for determination of the hepatic malondialdehyde (MDA) and glutathione (GSH) levels,myeloperoxidase (MPO) activity and collagen content.Production of reactive oxidants was monitored by chemiluminescence (CL) assay. Serum AST, ALT, LDH, and TNF-α levels were elevated in the BDL group as compared to control group and were significantly decreased by EGb treatment.RESULTS: Hepatic GSH level, depressed by BDL, was elevated back to control level in EGb-treated BDL group.Increase in tissue MDA level, MPO activity and collagen content due to BDL were also attenuated by EGb treatment.Furthermore, luminol and lucigenin CL values in BDL group increased dramatically compared to control and reduced by EGb treatment.CONCLUSION: Our results suggest that Ginkgo biloba protects the liver from oxidative damage following BDL in rats. This effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration of oxidant and antioxidant status in the tissue. | Gksel pener Levent Kabasakal Meral Yüksel Nursal Gedik Ynci Alican | 2005 | World Journal of Gastroenterology2005，11，35： | 7 |
| 3 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 4 | Reaching proficiency in laparoscopic splenectomy显示文摘AIM:To investigate the proficiency level reached in laparoscopic splenectomy using the learning curve method.METHODS:All patients in need of splenectomy for benign causes in whom laparoscopic splenectomy was attempted by a single surgeon during a time period of 6 years were included in the study (n=33). Besides demographics, operation-related variables and the response to surgery were recorded. The patients were allocated to groups of five, ranked according to the date of the operation. Operation duration, complications, postoperative length of stay, conversion to laparotomy and splenic weight were then compared between these groups.RESULTS: There was a significant difference regarding operation times between the groups (P = 0.001). An improvement was observed after the first 5 cases. The learning curve was flat up to the 25th case. Following the 25th case the operation times decreased still further. There was no difference between the groups regarding the other parameters.CONCLUSION: Unlike the widely accepted 'L' shape, the learning curve for laparoscopic splenectomy is a horizontal lazy 'S' with two distinct slopes. Privileges may be granted after the first 5 cases. However proficiency seems to require 25 cases. | Tarik Zafer Nursal Ali Ezer Sedat Belli Alper Parlakgumus Kenan Caliskan Turgut Noyan | 2009 | World Journal of Gastroenterology2009，15，32： | 3 |
| 5 | The effect of metoclopramide on gastric emptying in traumatic brain injury显示文摘 | Tarik Zafer Nursal Bulent Erdogan Turgut Noyan Melih Cekinmez Betul Atalay Nevzat Bilgin | 2005 | Journal of Clinical Neuroscience2005，，4： | 2 |
| 6 | Expression of survivin,bcl-2,P53 and bax in breast carcinoma and ductal intraepithelial neoplasia (DIN 1a)显示文摘 | Kayaseleuk F Nursal TZ Polat A | 2004 | J Exp Clin Cancer Res2004，23，1： | 1 |
| 7 | Expression of survivin, Bc1-2, p53 and Bax inbreast carcinoma and ductal intraepithelial neoplasia (DIN la) 显示文摘 | Kayaselcuk F Nursal TZ Polat A | 2004 | J Exp Clin Cancer Res2004，23，1： | 1 |
| 8 | Micmvessel density,VEGF expression,and tumor-associated macrophages in breast tumors : cor- relations with prognostic Parameters 显示文摘 | Bolat F Kayaselcuk F Nursal TZ | 2006 | J E:cp Clin Cancer Res2006，25，3： | 1 |
| 9 | Is routine preoperative ultrasonographic mapping for arteriovenous fislula creation necessary in patients with favorable physical examination findings? Results of a randomized eontrolled trial显示文摘 | Nursal TZ Oguzkurt L Tercan F | 2006 | World J Surg2006，30，6： | 1 |
| 10 | Transurethral prostateetomy and inguinal hernia repair in a single session显示文摘 | GUVEL S NURSAL TZ KILINC F | 2004 | Urol Int2004，73，3： | 1 |
| 11 | The effect of preoperative blood transfusion on morbidity and survival in colorectal malignancy显示文摘 | Nursal TZ Hamaloglu E | 2006 | Turk J Gastroenterol2006，17，4： | 1 |
| 12 | A method for thereduction of chronic pain after tension-free repair of inguinal her-nia:iliohypogastric neurectomy and subcutaneous transpositionof the spermatic cord显示文摘 | Caliskan K Nursal TZ Caliskan E | 2010 | Hernia2010，14，1： | 1 |
| 13 | The effect of metoclo- pramide on gasric emptying in traumatic brain injury 显示文摘 | Nursal T Z Erdogan B Noyan T | 2007 | J Clin Neurosci2007，14，4： | 1 |
| 14 | Assessment and Comparison of Anterior Chamber Dimensions Using Various Imaging Techniques显示文摘 | Dinc Umut Asli Oncel Banu Gorgun Ebru Yenerel Melda Nursal Alimgil Levent | 2010 | Ophthalmic Surgery Lasers and Imaging2010，，1： | 1 |
| 15 | The effect of metoclo- pramide on gastric emptying in traumatic brain injury 显示文摘 | Nursal TZ Erdogan B Noyan T | 2007 | J Clin Neurosci2007，14，4： | 1 |
| 16 | A new wei^ited scoring system forsubjective global assessment显示文摘 | Nursal TZ Noyan T Tarim A | 2005 | Nutrition2005，21，6： | 1 |
| 17 | The effect of metoelo- pramide on gastric emptying in traumatic brain injury显示文摘 | Nursal TZ Erdogan B Noyan T | 2007 | J Clin Neurasei2007，14，4： | 1 |
| 18 | Effect of drainage on postoperative nausea, vomiting, and pain after laparoscopic cholecystectomy显示文摘 | Tar?k Zafer Nursal Sedat Yildirim Akin Tarim Turgut Noyan Perran Poyraz Nusa Tuna Mehmet Haberal | 2003 | Langenbeck’s Archives of Surgery2003，，2： | 1 |
| 19 | Bacteriological profile and antibiotic resistance: comparison of findings in a burn intensive care unit, other intensive care units, and the hospital services unit of a single center 显示文摘 | Yildirim S Nursal T Z Tarim A | 2005 | J Burn Care Rehabilit2005，26，6： | 1 |
| 20 | Microvessel densi-ty, VEGF expression, and tumor - associated macrophagesin breast tumors : correlations with prognostic parameters显示文摘 | Bolat F Kayaselcuk F Nursal TZ | 2006 | J Exp Clin Cancer Res2006，25，3： | 1 |
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