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| 1 | Mechanisms of developmental programming of the metabolic syndrome and related disorders显示文摘There is consistent epidemiological evidence linking low birth weight, preterm birth and adverse fetal growth to an elevated risk of the metabolic syndrome (obesity, raised blood pressure, raised serum triglycerides, lowered serum high-density lipoprotein cholesterol and impaired glucose tolerance or insulin resistance) and related disorders. This 'fetal or developmental origins/programming of disease' concept is now well accepted but the 'programming' mechanisms remain poorly understood. We reviewed the major evidence, implications and limitations of current hypotheses in interpreting developmental programming and discuss future research directions. Major current hypotheses to interpret developmental programming include: (1)thrifty phenotype; (2) postnatal accelerated or catchup growth; (3) glucocorticoid effects; (4) epigenetic changes; (5) oxidative stress; (6) prenatal hypoxia; (7) placental dysfunction; and (8) reduced stem cell number. Some hypothetical mechanisms (2, 4 and 8) could be driven by other upstream 'driver' mechanisms. There is a lack of animal studies addressing multiple mechanisms simultaneously and a lack of strong evidence linking clinical outcomes to biomarkers of the proposed programming mechanisms in humans. There are needs for (1) experimental studies addressing multiple hypothetical mechanisms simultaneously; and (2) prospective pregnancy cohort studies linking biomarkers of the proposed mechanisms to clinical outcomes or surrogate biomarker endpoints. A better understanding of the programming mechanisms is a prerequisite for developing early life interventions to arrest the increasing epidemic of the metabolic syndrome, type 2 diabetes and other related disorders. | Anne-Monique Nuyt | 2010 | World Journal of Diabetes2010，1，3： | 7 |
| 2 | Language, Conceptualization and TAM Marking: A Cognitive-functional Perspective显示文摘At the level of empirical phenomena,this paper deals with the system of 'Tense Aspect Modality' marking or of 'qualificational categories' in language.How is this system organized? What are the principles behind it? The major focus is on the modal categories.At the theoretical level,this paper addresses issues pertaining to the organization and functioning of the cognitive systems involved in language use,with special focus on the differences and correspondences between two major theoretical strands in present day linguistics,viz.'functional linguistics' and 'cognitive linguistics'. | Jan Nuyts | 2009 | 外国语2009，32，1： | 7 |
| 3 | The effects of 5-fluorouracil and mitomycin C on the comeal endothelium 显示文摘 | Nuyts RM Pels E Greve EL | 1992 | Curr Eye Res1992，11，8： | 2 |
| 4 | Malignancies of the nasal cavity and paranasal sinuses: Long-term outcome with conventional or three-dimen- sional conformal radiotherapy显示文摘 | DIRIX P NUYTS S GEUSSENS Y | 2007 | Int J Radiat Oncol Biol Phys2007，69，： | 1 |
| 5 | Reduction of metal streak artifacts in x-ray computed tomography using a transmission maximum a posteriori algorithm显示文摘 | De Man B Nuyts J Dupont P | 2000 | IEEE Transactions on Nuclear Science2000，47，3： | 1 |
| 6 | Efficient isolation of total RNAfrom Clostridium without DNA contamination显示文摘 | Nuyts S Van Mellaert L Lambin P | 2001 | J Microbiol Methods2001，44，3： | 1 |
| 7 | Suppression of metal artifacts in CT using a reconstruction procedure that combines MAP and projection completion显示文摘 | Lemmens C Faul D Nuyts J | 2009 | IEEE Transactions on Medical Imaging2009，28，2： | 1 |
| 8 | ,Clostridium spores for tumor specific delivery显示文摘 | NUYTS S Van MELAERT L THEYS J | 2002 | Antitumor Drug2002，13，2： | 1 |
| 9 | Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the I13 receptor显示文摘 | Monaco G Decrock E Nuyts K | 2013 | PLoS One2013，8，73： | 1 |
| 10 | Comparison between MAP and postprocessed ML for image reconstruction in emission tomography when anatomical knowledge is available 显示文摘 | NUYTS J BAETE K BEQUE D | 2005 | IEEE Transactions on Medical Imaging2005，24，5： | 1 |
| 11 | An analytical model for Compton scatter in a homogeneously attenuating medium显示文摘 | Nuyts J | 1993 | IEEE Trans Med Imag1993，12，： | 1 |
| 12 | Radiationinduced xerostomia in patients with head and neck cancer: a literature review 显示文摘 | Dirix P Nuyts S Van den Bogaert W | 2006 | Cancer2006，107，11： | 1 |
| 13 | Radio-responsive recA promoter significantly increases TNF α production in recombinant clostridia after 2 Gy irradiation显示文摘 | Nuyts S van Mellaret L Theys J | 2001 | Gene Ther2001，8，15： | 1 |
| 14 | Dose–response relationships within the parotid gland after radiotherapy for head and neck cancer显示文摘 | Barbara Bussels Annelies Maes Patrick Flamen Philippe Lambin Katrien Erven Robert Hermans Sandra Nuyts Caroline Weltens Silvia Cecere Emmanuel Lesaffre Walter Van den Bogaert | 2004 | Radiotherapy and Oncology2004，，： | 1 |
| 15 | An iterative maximum-likelihood polychromatic algorithm for CT显示文摘 | Man BD Nuyts J Dupont P | 2001 | IEEE Transactions on Medical Imaging2001，20，10： | 1 |
| 16 | Clostridium spores for tumor-specific drug delivery显示文摘 | Nuyts S Van Mellaert L Theys J | 2002 | Anticancer Drug2002，13，2： | 1 |
| 17 | Subjectivity as an evidential dimension in epistemic modal expressions显示文摘 | Nuyts J | 2001 | Journal of Pragmatics2001，33，3： | 1 |
| 18 | The potential therapeutic gain of radiation-associated gene therapy with the suicide gene cytosine deaminase显示文摘 | LAMBIN P NUYTS S LANDUYT W | 2000 | Int J Radiat Biol2000，76，3： | 1 |
| 19 | New occupational risk factors for chronic renal failure 显示文摘 | NUYTS G D VAN VLEM E THYS J | 1995 | Lancet1995，346，8966： | 1 |
| 20 | Radiation-induced xerostomia in patients with head and neck cancer:a literature review显示文摘 | Dirix P Nuyts S Van den Bogaert W | 2006 | Cancer2006，107，24： | 1 |
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