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| 1 | Disseminated histoplasmosis in a 17-year-old Nigerian male patient:A case report显示文摘Rationale:Disseminated histoplasmosis is the most severe form of histoplasmosis and often associated with fatal outcomes.Both pulmonary and disseminated forms mimics tuberculosis(TB)and may be misdiagnosed.Patient concerns:A 17-year-old male patient compliant with anti-tuberculosis therapy with complaints of fever,cough productive of thick yellowish sputum,fast breathing,abdominal pain,swelling and jaundice.HIV status was negative.Diagnosis:Disseminated histoplasmosis.Interventions:Antimicrobials including anti-TB therapy,ceftriaxone,gentamicin,azithromycin and ciprofloxacin.Outcomes:He was responding to anti-TB drugs until about 4 and a half months on treatment when he fell ill.Peripheral blood film done 2 days prior to his demise revealed florid yeast like organisms in monocytes with eccentric chromatin suggestive of Histoplasma capsulatum.Lessons:Histoplasmosis can both mimic and coexist with TB and so a high index of suspicion is needed for its diagnosis. | Atana Uket Ewa Bassey Ewa Ekeng Glory Ekpo Bassey Enobong Ufot Akpah Osamagbe Aiyudubie Asemota Livinus Nwancho Nweke | 2022 | Asian Pacific Journal of Tropical Medicine2022，15，6： | 1 |
| 2 | Microbial growth and substrate utilization kinetics 显示文摘 | Okpokwasili G C Nweke C O | 2006 | Afr J Biotechnol2006，5，： | 1 |
| 3 | Toxicity of binary mixtures of formulated glyphosate and phenols to rhizobinm species dehydrogenase activity显示文摘 | Nweke C O Ahurrn'be N C Orji J C | 2014 | Journal of Microbiology Research2014，4，4： | 1 |
| 4 | Microbial growth and substrate utilization kinetics显示文摘 | OKPOKWASILIL G C NWEKE C O | 2005 | African Journal of Biotechnology2005，5，30： | 1 |
| 5 | Experimental charac- terization of the separation between wavelength-multiplexed quantum and classical communication channels 显示文摘 | NWEKE N I TOL1VER P RUNSER R J | 2005 | Applied Physics Letters2005，87，17： | 1 |
| 6 | Healthcare-seeking be- havior, treatment delays and its determinants among pulmonary tu- berculosis patients in rural Nigeria: a cross-sectional study显示文摘 | UKWAJA KN ALOBU I NWEKE CO | 2013 | BMC Health Serv Res2013，，13： | 1 |
| 7 | Incompleteness of wastewater dechlofination 显示文摘 | George Helz R Anthony Nweke C | 1995 | Environmental Science Technology1995，，29： | 1 |
| 8 | Microbial growth and substrate utilization kinetics显示文摘 | Okpokwasili G C Nweke C O | 2005 | African Journal of Biotechnology2005，5，4： | 1 |
| 9 | Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis显示文摘BACKGROUND Acute pancreatitis(AP)is an inflammatory disease,which presents with epigastric pain and is clinically diagnosed by amylase and lipase three times the upper limit of normal.The 2012 Atlanta classification stratifies the severity of AP as one of three risk categories namely,mild AP(MAP),moderately severe AP(MSAP),and severe AP(SAP).Challenges in stratifying AP upon diagnosis suggest that a better understanding of the underlying complex pathophysiology may be beneficial.AIM To identify the role of the chemokine receptor 8(CCR8),expressed by T-helper type-2 Lymphocytes and peritoneal macrophages,and its possible association to Interleukin(IL)-6 and AP stratification.METHODS This study was a prospective case-control study.A total of 40 patients were recruited from the Chris Hani Baragwanath Academic Hospital and the Charlotte Maxeke Johannesburg Academic Hospital.Bioassays were performed on 29 patients(14 MAP,11 MSAP,and 4 SAP)and 6 healthy controls as part of a preliminary study.A total of 12 mL of blood samples were collected at Day(D)1,3,5,and 7 post epigastric pain.Using multiplex immunoassay panels,real-time polymerase chain reaction(qRT-PCR)arrays,and multicolour flow cytometry analysis,immune response-related proteins,genes,and cells were profiled respectively.GraphPad Prism^(TM) software and fold change(FC)analysis was used to determine differences between the groups.P<0.05 was considered significant.RESULTS The concentration of IL-6 was significantly different at D3 post epigastric pain in both the MAP group and MSAP group with P=0.001 and P=0.013 respectively,in a multiplex assay.When a FC of 2 was applied to identify differentially expressed genes using RT2 Profiler,CCR8 was shown to increase steadily with disease severity from MAP(1.33),MSAP(38.28)to SAP(1172.45)median FC.Further verification studies using RT-PCR showed fold change increases of CCR8 in MSAP and SAP ranging from 1000 to 1000000 times when represented as Log10,compared to healthy control respectively at D3.The findings also showed differing lymphocyte and monocyte cell frequency between the groups.With monocyte population frequency as high as 70%in MSAP at D3.CONCLUSION The higher levels of CCR8 and IL-6 in the severe patients and immune cell differences compared to MAP and controls provide an avenue for exploring AP stratification to improve management. | Mwangala Nalisa Ekene Emmanuel Nweke Martin D Smith Jones Omoshoro-Jones John WS Devar Rebecca Metzger Tanya N Augustine Pascaline N Fru | 2021 | World Journal of Gastrointestinal Pathophysiology2021，12，6： | 1 |
| 10 | Microbial growth and substrate utilization kinetics显示文摘 | Okpokwasili G C Nweke C O | 2006 | African Journal of Biotechnology2006，5，： | 1 |
| 11 | Incompleteness of wastewater dechlorination 显示文摘 | Helz R G Nweke C A | 1995 | Environmental Science Technology1995，29，6： | 1 |
| 12 | Modern environmental health hazards: a public health issue of increasing significance in Africa 显示文摘 | Nweke OC 3rd Sanders WH | 2009 | Environ Health Perspect2009，117，6： | 1 |
| 13 | Simple sequence re- peat polymorphisms in nigerian sesame euhivars and its rela- tionship with morpho-agronomic traits显示文摘 | NWEKE F N UBI B E KUNERT K | 2011 | Journal of Crop Im- provement2011，25，5： | 1 |
| 14 | Kinetics of zinc toxicity to environmental bacterial isolate 显示文摘 | Nweke C O | 2009 | Ambi-Agua Taubate2009，4，： | 1 |
| 15 | Microbial growth and substrate utilizaliton kinetics 显示文摘 | Okpokwasili G C Nweke C O | 2005 | African Journal of Biotechnolo- gy2005，5，4： | 1 |
| 16 | Incompleteness of wastewater dechlorination显示文摘 | Helz G R Nweke A C | 1995 | Environ Sci Technol1995，29，4： | 1 |
| 17 | Association of Obesity and Dyslipidaemia with Type 2 Diabetes in Outpatients of Enugu State University Teaching Hospital (ESUTH)in Enugu Nigeria显示文摘 | Godwill Azeh Engwa Amanda Okolie Friday Nweke Nwalo Emmanuela Akaniro-Ejim Marian N.Unachukwu Micheal Ndidiamaka Ozofor Kingsley N. Agbafor Benjamin Ewa Ubi | 2018 | Journal of Life Sciences2018，12，2： | 0 |
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