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| 1 | Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome显示文摘AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a normal Danish/Western diet(ND)in patients with IBS fulfilling Rome III diagnostic criteria,recruited betweenNovember 2009 and April 2013.Patients were required to complete on a weekly basis the IBS severity score system(IBS-SSS)and IBS quality of life(IBS-QOL)questionnaires in a specially developed IBS web selfmonitoring application.We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.RESULTS:One hundred twenty-three(median age 37years,range:18-74 years),90(73%)females were randomised:42 to LFD,41 to LGG and 40 to ND.A significant reduction in mean±SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed:133±122 vs 68±107,133±122 vs 34±95,P<0.01.Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND(IBS-SSS score75;95%CI:24-126,P<0.01),but not in LGG compared to ND(IBS-SSS score 32;95%CI:18-80,P=0.20).IBS-QOL was not altered significantly in any of the three groups:mean±SD in LFD 8±18 vs LGG 7±17,LFD 8±18 vs ND 0.1±15,P=0.13.CONCLUSION:LFD is efficacious for patients with IBS. | Natalia Pedersen Nynne Nyboe Andersen Zsuzsanna Végh Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Mette Hestetun Simonsen Johan Burisch Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，43： | 16 |
| 2 | Risk of infections associated with biological treatment in inflammatory bowel disease显示文摘Tumor necrosis factor-α(TNF-α)inhibitors are biological agents introduced in the late 1990s for the treatment of different immune-mediated diseases as inflammatory bowel disease,rheumatoid arthritis and psoriasis.The most commonly used TNF-αantagonists are infliximab,adalimumab,and certolizumab pegol,and though highly effective in lowering inflammation,the efficacy must be weighed against the potential for adverse events.The treatment-induced immunosuppression is suspected to increase the risk of infections,including the risk of reactivation of latent tuberculosis,as the TNF-αcytokine plays an important role in the immune function.In this topic highlight a short overview of the infection risk associated with TNF-αinhibiter therapy is outlined with a focus on the overall risk of serious infections,mycobacterial infection and latent viral infections. | Nynne Nyboe Andersen Tine Jess | 2014 | World Journal of Gastroenterology2014，20，43： | 9 |
| 3 | Fitness and health benefits of team handball training for young untrained women--A cross-disciplinary RCT on physiological adaptations and motivational aspects显示文摘Purpose: The present study evaluated the effects of regular participation in small-sided team handball training on body composition, osteogenic response, physical performance, and cardiovascular risk factors, as well as well-being and motivation, in young untrained women.Methods: Twenty-eight untrained 20- to 30-year-old women were randomized to a handball training group(HG; n = 14, height 170 ± 5 cm, weight 73 ± 11 kg, VO_(2peak) 37.7 ± 4.1 mL/min/kg) that trained 1.7 ± 0.3 times per week over 12 weeks(70 min 4 v 4 handball sessions) or an inactive control group(CG; n = 14, 169 ± 5 cm, 71 ± 12 kg, 38.1 ± 3.7 mL/min/kg). Physiological and psychological and motivational training adaptations were assessed pre-and post-intervention by dual-energy X-ray Absorptiometry(DXA) scans, blood sampling, physical tests, and questionnaires.Results: The average heart rate(HR) over all training sessions was equal to 85% ± 6% HR_(max). Between-group intervention effects were observed in favor of HG for muscle mass(2.1%, p = 0.024), proximal femur bone mineral density(0.8%, p = 0.041), Yo-Yo IE1 intermittent endurance test level 1(IE1) performance(35%, p < 0.001), and incremental treadmill test performance(11.5%, p = 0.003), but not total fat mass(p = 0.176),mean arterial blood pressure(p = 0.328), resting HR(p = 0.219), or blood lipids(p = 0.298—0.854). In CG, no changes were observed in any of the measured physiological variables after the training period. Compared to CG, HG had an increase in intrinsic motivation(p < 0.001) and in the well-being subscale 'energy'(p = 0.010).Conclusion: Participation in regular recreational team handball training organized as small-sided games has marked beneficial effects on physical performance, musculoskeletal fitness, well-being, and motivation in untrained young women. | Therese Hornstrup Johan M.Wikman Bjorn Fristrup Susana Povoas Eva W.Helge Signe H.Nielsen Jorn W.Helge Jesper L.Andersen Lars Nybo Peter Krustrup | 2018 | Journal of Sport and Health Science2018，7，2： | 8 |
| 4 | Has the risk of colorectal cancer in inflammatory bowel disease decreased?显示文摘The association between inflammatory bowel disease(IBD)and colorectal cancer(CRC)has been acknowledged for almost a century and is assumedly promoted by a chronic inflammation-driven carcinogenic process in the intestine in combination with a genetic predisposition.The magnitude of the risk of CRC in IBD remains a continuing subject of debate.The early,high risk estimates for CRC in IBD were most likely overestimated due to selected patient populations originating from tertiary referral centers with a disproportional high percentage of patients with severe disease.Later population-based studies calculating risk estimates from a broad spectrum of IBD patients have found the risk to be significantly lower.At present,there is evidence that IBD patients with longstanding and extensive disease with uncontrolled inflammation are those at increased risk.Additional,other recognized risk factors include early age at onset,family history of CRC,and concomitant primary sclerosing cholangitis.A significant amount of effort is put into identifying potential preventive factors of CRC in IBD,including surveillance programs and chemopreventive agents but the individual effect of these remains uncertain.Interestingly,recent studies have reported a decline in risk of CRC over time.Surveillance programs and the new treatment strategies,particular biological treatment might be part of the reason for the observed decline in risk of CRC in IBD over time but future studies will have investigate this assumption. | Nynne Nyboe Andersen Tine Jess | 2013 | World Journal of Gastroenterology2013，19，43： | 7 |
| 5 | Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet显示文摘In the present study we report on changes in irritable bowel syndrome-severity scoring system(IBS-SSS)and irritable bowel syndrome-quality of life(IBS-QoL)in 19 IBS patients,aged 18 to 74 years(F/M:14/5),during 12 wk registering their symptoms on the webapplication(www.ibs.constant-care.dk).During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention.Thereafter,low fermentable oligo-,di-,mono-saccharides and polyols(FODMAP)diet(LFD)was introduced for the next6 wk while continuing the registration.Though a small sample size a significant improvement in disease activity(IBS-SSS)was observed during both the control period,median:278(range:122-377),P=0.02,and subsequently during the LFD period,median:151(range:29-334),P<0.01.The IBS-QoL solely changed significantly during the LFD period,median:67(37-120),P<0.01.The significant reduction in disease activity during the control period shows a positive effect of the web-application on IBS symptoms when presented as a'traffic light'.However adding the diet reduced IBSSSS to<150,inactive to mild symptoms.In the future results from larger scale trials are awaited. | Natalia Pedersen Zsuzsanna Vegh Johan Burisch Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Nynne Nyboe Andersen Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，21： | 7 |
| 6 | WONCA研究论文摘要汇编——肿瘤坏死因子α抑制剂与炎症性肠炎患者严重感染风险的关系:丹麦全国性队列研究显示文摘目的探讨肿瘤坏死因子α(TNF-α)抑制剂是否会增加严重感染风险。设计以全国登记资料为基础的倾向分数匹配队列研究。地点丹麦,2002年12月。参与者获得匹配资格的背景队列包含52392例炎症性肠炎患者,年龄15—75岁,其中4300例接受TNF—α抑制剂治疗。为了避免混淆,使用两个阶段匹配法:首先匹配年龄、性别、病程、炎症性肠炎亚型;之后匹配倾向分数(1:1比例)。最后将接受TNF—d抑制剂治疗的1543例患者与未接受TNF一0【抑制剂治疗的1543例患者纳入研究。主要结果指标主要结果指标是严重感染,即确诊为入院造成的感染。进行Cox比例风险回归分析,计算两个高危时期(TNF-α抑制剂治疗90d后和365d后)的风险率。特定位点严重感染的风险率只在356d获取。结果在90d,51例接受TNF—α抑制荆治疗的患者发生感染(发生率14/100人年),33例未接受TNF—α抑制剂治疗的患者发生感染(9/100人年),风险率为1.63[95%CI(1.01,2.63)]。在365d,风险率为1.27[95%CI(0.92,1.75)]。特定位点感染分析中,多个亚组的风险率超过2.00,有皮肤和软组织感染者风险率为2.51[95%[(1.23,5.12)]。结论这项全国性倾向分数匹配队列研究证明,开始治疗90d内使用TNF—d抑制剂会增加严重感染风险,后期风险率会降低。建议临床工作加强对炎症性肠炎患者潜在感染并发症的重视,尤其是在治疗早期。 | Nyboe Andersen N Pasternak B Friis-Mφller N 本刊编辑部 | 2015 | 中国全科医学2015，18，24： | 6 |
| 7 | 高温环境中训练和比赛的共识性建议显示文摘高温环境中运动会引起体温调节和其它生理压力,继而可导致耐力运动能力的损害。本共识性声明的目的是提供最新的建议以使热环境中体育活动时的运动能力最优化。可用于降低热应激压力和优化运动能力的最重要干预方式是热习服,其应包括1~2周以上反复的运动—高温环境暴露。此外,运动员应在正常水合状态下开始比赛和训练,并将运动中的脱水最小化。随着商用降温系统(如降温背心)的发展,在高温环境中训练或比赛前,运动员可以采取降温策略来促进热的散发或提高蓄热能力。而且,赛事组织者应该设计大面积的遮阳区域,并提供降温和补水设施,按照最小化运动员的健康风险来安排赛事,尤其是在大众参与的赛事中及一年之中炎热天气开始之初。以最近的2008年奥运会和2014年国际足联世界杯为例,当比赛在高温环境中举行时,赛事主管机构应考虑在比赛中或比赛之间允许额外的(或更长的)恢复期以提供补水和降温的时机。 | Sébastien Racinais Juan-Manuel Alonso Aaron J.Coutts Andreas D.Flouris Olivier Girard José González -Alonso Christophe Hausswirth Ollie Jay Jason K.W.Lee Nigel Mitchell George P.Nassis Lars Nybo Babette M.Pluim Bart Roelands Michael N.Sawka Jonathan Wingo Julien D.Périard. 徐金成 高璨 赵杰修 | 2016 | 中国运动医学杂志2016，35，2： | 4 |
| 8 | Risk of cardiovascular disease in inflammatory bowel disease显示文摘Abundant scientific evidence supporting an association between inflammatory bowel disease(IBD) and venous thromboembolic events, caused by an IBD related hypercoagulability, is acknowledged and thromboprophylactic treatment strategies are now implemented in the management of IBD patients. In contrary, the risk of arterial thromboembolic disease, as ischemic heart disease, cerebrovascular events, and mesenteric ischemia in patients with IBD remains uncertain and the magnitude of a potentially increased risk is continuously debated, with ambiguous risk estimates among studies. The evident role of inflammation in the pathogenesis of atherosclerosis forms the basis of a biological plausible link; the chronic systemic inflammation in IBD patients increases the risk of atherosclerosis and thereby the risk of thrombotic events. Further, studies have shown that the burden of traditional risk factors for atherosclerosis, such as obesity, diabetes mellitus, and dyslipidemia is lower in IBD populations, thus further strengthen the role of non-traditional risk factors, as chronic inflammation in the linking of the two disease entities. Likewise, mortality from cardiovascular disease in IBD remains questioned. The aim of the current review is to give an up-date on the existing evidence of the possible association between IBD and cardiovascular disease and to discuss traditional and non-traditional risk factors. | Nynne Nyboe Andersen Tine Jess | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 3 |
| 9 | 我们应该怎样利用新抗凝剂治疗急性肺栓塞?显示文摘由于大多数的治疗都增加了出血并发症的风险,因此急性肺栓塞(pulmonary embolism,PE)患者的治疗成为临床医生面临的一大挑战。80%的PE患者具有可识别的诱发因素, | Jens Eckardt Mads Nybo 章仲恒 何建行 | 2013 | 国际病理科学与临床杂志2013，33，3： | 2 |
| 10 | Denaturing High-performance Liquid Chromatography mutation analysis in patients with reduced Protein S levels 显示文摘 | Lise Bathum Anna-Marie Mtl nster Mads Nybo | 2008 | Clinica Chimica Acta 20082008，7681，： | 1 |
| 11 | N-ter- minal pro brain natriuretic peptide reflects long-term com- plications in type 1 diabetes 显示文摘 | GRAUSLUND J NYBO M GREEN A | 2010 | Scand J Clin Lab In- vest2010，70，6： | 1 |
| 12 | CNS fatigue provoked by prolonged exercise in the heat 显示文摘 | Nybo L | 2010 | Front Biosci2010，2，： | 1 |
| 13 | Incidence of Alcoholic Chronic Pancreatitis in Copenhagen显示文摘 | B. Nyboe Andersen N. Thorsgaard Pedersen J. Scheel H. Worning | 1982 | Scandinavian Journal of Gastroenterology1982，，2： | 1 |
| 14 | Serious anaphylactic reactions due to protamine sulfate: a systematic literature review 显示文摘 | Nybo M Madsen JS | 2008 | Basic Clin Pharmacol Toxicol2008，103，2： | 1 |
| 15 | Cerebtal perturbations provoked by pro-longedexercise显示文摘 | Nybo L SecherNH | 2004 | Prog Neurobiol2004，73，4： | 1 |
| 16 | Severe arterial thrombosis in a family with type Ⅲ protein S deficiency caused by a frameshift mutation in the PROS1 gene显示文摘 | Larsen TB Brusgaard K Nybo M | | 0，，2： | 1 |
| 17 | Evidenced-based investigations and treatments of recurrent pregnancy loss显示文摘 | Christiansen OB Nybo AAM Bosch E | 2005 | Fertil Steril2005，83，4： | 1 |
| 18 | Cerebral perturbations provoked by prolonged exercise显示文摘 | Nybo L Secher NH | 2004 | Prog Neurobiol2004，72，4： | 1 |
| 19 | Influence of systolic and diastolic blood pressure on stroke risk: a prospective observational study显示文摘 | Lindenstrom E Boysen G Nyboe J | 1995 | Am J Epidemiol1995，142，12： | 1 |
| 20 | Acupuncture onthe day of embryo transfer: a randomized controlled trial of 635 pa- tients 显示文摘 | Andersen D L0ssl K Nyboe Andersen A | 2010 | Reprod BioMed Online2010，21，： | 1 |
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