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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Polymer and Bio- polymer Mediated Self-assembly of Gold Nanoparticles显示文摘 | OFIR Y SAMANTA B ROTELLO V M | 2008 | Chemical Society Reviews2008，37，9： | 1 |
| 3 | MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E显示文摘 | Ofir M Hacohen D Ginsberg D | | 0，，04： | 1 |
| 4 | Parallel algorithms for approximation of distance maps on parametric surfaces显示文摘 | Ofir Weber Yohai S Devir Alexander M Bronstein | 2008 | ACM Trans Graph2008，27，4： | 1 |
| 5 | Comparison of oral mucosal pH valuesin bulimia nervosa,GERD,BMS patients and healthy population显示文摘 | Aframian DJ Ofir M Benoliel R | 2010 | Oral Dis2010，16，8： | 1 |
| 6 | Multiple fetal intracardiac echogenic foe:not always a benign sonographic finding显示文摘 | Bronshtein M Jakobi P Ofir C | 1996 | Prenat Diagn1996，16，2： | 1 |
| 7 | Comparison of oral mucosal pH values in bulimia nervosa,GERD,BMS patients and healthy population显示文摘 | Aframian D J Ofir M Benoliel R | 2010 | Oral Dis2010，16，： | 1 |
| 8 | miR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-in- duced proliferation by targeting Cyclin E显示文摘 | OFIR M HACOHEN D GINSBERG D | 2011 | Molecular Cancer Research2011，9，4： | 1 |
| 9 | Comparison of oral mucosal pH values in bulimia nervosa,GERD,BMS patients and healthy popu- lation 显示文摘 | Aframian DJ Ofir M Benoliel R | 2010 | Oral Dis2010，16，8： | 1 |
| 10 | Multiple fetal intracardiac echogenic foci: not always a benign sonographic finding 显示文摘 | Bronshtein M Jakobi P Ofir C | 1996 | Prenat Diagn1996，16，2： | 1 |
| 11 | MuItiple fetal intracaidiac echogenic foci:not always a benign sonographic finding显示文摘 | Bronshtein M Jakovi P Ofir C | 1996 | Prenat Diagn1996，16，： | 1 |
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