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	题名	作者	年代	出处	被引量
1	Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters.	V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun	2003	World Journal of Gastroenterology2003，9，10：	5
2	Cranial Doppler uhrasonography as a predictor of neurologic sequelae in infants with bacterial meningitis显示文摘	Okten A Ahmetoglu A Dilber E	2002	Invest Radiol2002，37，2：	1
3	Tuberculous peritonitis--reports of 26 cases,detailing diagnostic and therapeutic problems显示文摘	Demir K Okten A Kaymakoglu S		0，，05：	1
4	The ratio of second and fourth digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency显示文摘	Okten A Kalyoncu M Yaris N	2002	Early Hum Dev2002，70，12：	1
5	Spontaneous ascitic in- fection in different cirrhotic groups:prevalence, risk factors and the efficacy of cefotaxime therapy 显示文摘	Kaymakoglu S Eraksoy H Okten A	1997	Eur J Gastroenterol Hepatol1997，9，1：	1
6	The ratio of second- and fourthdigit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency显示文摘	Okten A Kalyoncu M Yaris N	2002	Early Hum Dev2002，70，：	1
7	The ratio of second and fourth digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency显示文摘	Okten A Kalyoncu M Yaris N	2003	Early Human Development2003，70，70：	1
8	Cranial Doppler ultrasoundgraphy as a predictor of neurologic sequelae in infants with bacterialmeningitis显示文摘	Okten A Ahmetoglu A Dilber E	2002	Invest Radiol2002，37，2：	1
9	Cranial Doppler ultrasonography as a predictor o f neurologic sequelae in infants with bacterial meningitis显示文摘	Okten A Ahmetoglu A Dilber E	2002	Invest Radiol2002，37，2：	1
10	Two cases with pachy- dermoperiostosis and discussion of tamoxifen citrate treatment for arthralgia 显示文摘	Okten A Mungan I Kalyoncu M et ol	2007	Clin Rheumatol2007，26，1：	1
11	Sturge Weber syn- drome accompanied with multiple congenital intrac- ranial lesions 显示文摘	Ergtin R Okten A I Gezercan Y	2007	Acta Neurochir ( Wien)2007，149，8：	1
12	A spinal dermoid cyst with spontaneous rupture into the syrinx cavity:a case report显示文摘	Ozsoy KM Okten AI Arslan A	2014	Turk Neurosurg2014，24，2：	1
13	Traumatic subarachnoid hemorrhage:a p rospective study of 58 cases显示文摘	Okten A I Gezercan Y Ergun R	2006	Ulus Travma Acil errahi Derg2006，12，2：	1
14	The ratio of second- and fourth digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency显示文摘	Okten A Kalyoncu M Yaris N	2002	Early Human Development2002，70，：	1
15	Generating low-discrepancy sequencesfrom the normal distribution;Box-Muller or inverse trans-form?显示文摘	OKTEN G GONCU A	2011	Mathematical and Computer Modelling2011，53，56：	1
16	Two cases with pachydermoperiostosis and discussion of tamoxifen citrate treatment for arthralgia显示文摘	Okten A Mungan I Kalyoncu M	2007	Clin Rheumatol2007，26，1：	1
17	On pricing discrete barrier options using conditional expectation and importance sampling Monte Carlo 显示文摘	Okten G Salta E Goncu A	2008	Mathematical and Computer Modelling2008，47，34：	1
18	Three-dimensional volume rendering digital subtraction angiography in comparison with two-dimensional digital subtraction angiography and rotational angiography for detecting aneurysms and their morphological properties in patients with subarachnoid hemorrhage显示文摘	Kucukay F Okten RS Tekiner A	2012	Eur J Radiol2012，81，10：	1
19	Two cases with pachydermoperiostosis and discussion of tamoxifen citrate treatment for arthralgia显示文摘	Okten A Mungan I Kalyoncu M	2007	Clin Rheumatol2007，26，：	1
20	Two eases with paehydermope- fiostosis and discussion of tamoxifen eitrate treatment for arthralgia 显示文摘	Okten A Mungan I Kalyoneu M	2007	Clin Rheumatol2007，26，：	1

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