|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Keratinocyte 生长 factor-2 和自体同源的浆液加强处于在老鼠的角膜损坏的间充质的干细胞的再生效果显示文摘AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KGF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency.Bone marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial cells.METHODS:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow donors.Group I rats received AM+MSCs,Group II rats AM+MSCs cultured with KGF-2,Group III rats AM+MSCs cultured with KGF-2+AS,Group IV rats only AM and Group V rats,none.AS was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same animals.Therapeutic effect was evaluated with clinical,histopathological and immunohistochemical assessment.MSC engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain reaction.RESULTS:Corneal healing was significantly better in Groups I-III rats treated with MSC transplantation compared to Group IV and Group V rats with supportive treatment only.The best results were obtained in Group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of cornea.CONCLUSION:We suggest that culture of MSCs with KGF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells. | Ferda Alpaslan Pinarli Gülsen Okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 3 | Cranial Doppler uhrasonography as a predictor of neurologic sequelae in infants with bacterial meningitis显示文摘 | Okten A Ahmetoglu A Dilber E | 2002 | Invest Radiol2002，37，2： | 1 |
| 4 | Dynamic contrast en-hanced MRI in the differential diagnosis of soft tissue tumors显示文摘 | Tuncbilek N Karakas HM Okten OO | 2005 | Eur J Radiol2005，53，3： | 1 |
| 5 | Tuberculous peritonitis--reports of 26 cases,detailing diagnostic and therapeutic problems显示文摘 | Demir K Okten A Kaymakoglu S | | 0，，05： | 1 |
| 6 | Traumatic subarachnoid hemorrhage: a prospective study of 58 cases显示文摘 | Okten AI Gezercan Y Ergun R | 2006 | Ulus Travma Acil CerrahiDerg2006，12，2： | 1 |
| 7 | Two cases with pachydermoperiostosis and discussion of tamoxifen citrate treatment for arthralgia显示文摘 | Ay?enur Okten Ilke Mungan Mukaddes Kalyoncu Zerrin Orbak | 2007 | Clinical Rheumatology2007，，1： | 1 |
| 8 | Capecitabine and oxaliplatin (XELOX) as first-line treatment for patients with metastatic colorectal cancer显示文摘 | Karaeetin D Yalein B Okten B | 2009 | J BUON2009，14，4： | 1 |
| 9 | The ratio of second and fourth digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency显示文摘 | Okten A Kalyoncu M Yaris N | 2002 | Early Hum Dev2002，70，12： | 1 |
| 10 | Intermediaries and Corruption显示文摘 | Hasker Kevin Okten Cagla | 2008 | Journal of Economic Behavior and Organization2008，67，1： | 1 |
| 11 | Traumatie subarachnoid hemorrhage: aprospeetive study of 58 eases 显示文摘 | Okten AI Gezerean Y Ergun R | 2006 | Ulus Travma Aeil CerrahiDerg2006，12，2： | 1 |
| 12 | Traumatic subarachnoid hemorrhage:a prospective study of 58 cases显示文摘 | Okten AI Gezercan Y Ergün R | | 0，，02： | 1 |
| 13 | Dynamic magnetic reso-nance imaging in determining histopathological prognostic factorsof invasive breast cancers 显示文摘 | Tuncbilek N Karakas HM Okten 00 | 2005 | Eur J Radiol2005，53，2： | 1 |
| 14 | Cap ecitabine and oxaliplatin(XELOX)as first-line treatment for patinets with metastatic colorectal cancer显示文摘 | Karacitin D Yalcin B Okten B | 2009 | J BUON2009，14，4： | 1 |
| 15 | Kala-azar in Trabzon (Eastern black sea) region of Turkey显示文摘 | H. Mocan Y. Gedik A. Okten E. Erduran N. Gacar | 1993 | The Indian Journal of Pediatrics1993，，6： | 1 |
| 16 | Determinants of Dona- tions in Private Nonprofit Markets显示文摘 | Okten C and Weisbrod B | 2000 | Journal of Public Economics2000，，75： | 1 |
| 17 | Spontaneous ascitic in- fection in different cirrhotic groups:prevalence, risk factors and the efficacy of cefotaxime therapy 显示文摘 | Kaymakoglu S Eraksoy H Okten A | 1997 | Eur J Gastroenterol Hepatol1997，9，1： | 1 |
| 18 | The ratio of second- and fourthdigit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency显示文摘 | Okten A Kalyoncu M Yaris N | 2002 | Early Hum Dev2002，70，： | 1 |
| 19 | The ratio of second and fourth digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency显示文摘 | Okten A Kalyoncu M Yaris N | 2003 | Early Human Development2003，70，70： | 1 |
| 20 | Cranial Doppler ultrasoundgraphy as a predictor of neurologic sequelae in infants with bacterialmeningitis显示文摘 | Okten A Ahmetoglu A Dilber E | 2002 | Invest Radiol2002，37，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员