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463篇 您的检索式：作者名="OLIVER J C"

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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘	Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini	2007	Lancet Oncology2007，，：	2
3	Maximum likelihood approach to the detection of changes between muhitemporal SAR images 显示文摘	Lombardo P Oliver C J	2001	Radar Sonar and Navigation IEE Proceedings2001，148，4：	1
4	On the Measurement of Stress-strain Curves by Spherical Indentation显示文摘	E G Herbert G M Pharr W C Oliver B N Lucas J L Hay	2001	Thin Solid Films2001，，：	1
5	Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘	Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G	1998	Nature1998，393，：	1
6	Bovine lactofemn supplementation supports immune and antioxidant status in healthy human males显示文摘	MULDER A M CONNELLAN P A OLIVER C J	2008	Nutrition Research2008，28，：	1
7	Smooth muscle cells orchestrate the endothelial cell response to flow and injury 显示文摘	Balcells M Martorell J Olive C	2010	Circulation2010，121，20：	1
8	Induction of hair growth in ear wounds by cultured dermal papilla cells显示文摘	JAHODA C A REYNOLDS A J OLIVER H F	1993	J Invest Dermatol1993，101，4：	1
9	Arteriovenous fistula outcomes in the era of the elderly dialysis population 显示文摘	Lok C Oliver M Su J	2005	Kidney Int2005，67，6：	1
10	The legitimacy of strategic alliances: An institutional perspective显示文摘	Dacin M T Oliver C Roy J P	2007	Strategic Management Journal2007，28，2：	1
11	Information Content of Coherent Image显示文摘	Blacknell D Oliver C J	1993	Journal of Physics D:Applied Physics1993，26，9：	1
12	Cloning,sequence comparison and in vivo expression of the gene encoding rat P-selectin显示文摘	AUCHAMPACH J A OLIVER M G ANDERSON D C	1994	Gene1994，145，：	1
13	Breaking a para digm : Male produced aggregation pheromone for Colorado pota to beetle显示文摘	Dickens J C Oliver J E Hollister B	2002	J Exp Biol2002，205，：	1
14	Fat-suppressed spoiled gradient-recalled imaging of equine metacarpophalangeal articular cartilage显示文摘	Olive J D'Anjou MA Girard C	2010	Vet Radiol Utrasound2010，51，2：	1
15	Size Dependence of Mechan- ical Properties of Gold at the Micron Scale in the Absence of Strain Gradients显示文摘	Greer J R Oliver W C Nix W D	2005	Acta Materialia2005，53，6：	1
16	Institutional Embeddedness and the Dynamics of Organizational Populations显示文摘	BAUM J A C OLIVER C		0，，：	1
17	OMEGA EP high-energy petawatt laser: progress and prospects显示文摘	D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien	2008	Journal of Physics: Conference Series2008，，3：	1
18	In situ monitoring of pitting corrosion in aluminum alloy 2024显示文摘	C M Liao J M Olive Gao M	1998	Corrosion1998，54，：	1
19	A new maximum likelihood joint segmentation technique for multitemporal SAR and multiband optical images显示文摘	LOMBARDO P OLIVER C J PELLIZZERI T M	2003	IEEE Transactions on Geoscience and Remote Sensing2003，41，11：	1
20	Glutathione metabolic genes co-ordinately respond to heavy metals and jasmonic acid in Arabidopsis显示文摘	Xiang C Oliver D J	1998	Plant Cell1998，10，：	1

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