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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Aflatoxin Exposure and Viral Hepatitis in the Etiology of Liver Cirrhosis in The Gambia, West Africa显示文摘 | Kuniholm Mark H Lesi Olufunmilayo A Mendy Maimuna Akano Aliu O Sam Omar Hall Andrew J Whittle Hilton Bah Ebrima Goedert James J Hainaut Pierre Kirk Gregory D | 2008 | Environmental Health Perspectives2008，，11： | 2 |
| 3 | A leadless intracardiac transcatheter pacing system显示文摘 | Reynolds D Duray GZ Omar R | 2016 | N Engl J Med2016，374，6： | 1 |
| 4 | Molecular identification and virulence of six isolates of Metarhizium anisopliae (Deuteromycotina: Hyphomycetes ) to Bemisia tabaci Q biotype 显示文摘 | Islam MT Omar D Shabanimofrad M | 2014 | Journal of Asia-Pacifw Entomology2014，17，3： | 1 |
| 5 | The drosophila Bcl-2 family member dBorg-1 functions in the apoptotic response to UV- irradiation显示文摘 | Carrie Baker Brachmann Omar W Jassim Benjamin D Wachsmuth | 2000 | Current Biology2000，10，： | 1 |
| 6 | Regulation of sympathatic activity inchildrenwith vanous congenital heart diseaess 显示文摘 | Omar G Omar G | 1995 | Pediatr Res1995，38，1： | 1 |
| 7 | Superoxide anion inhibits cGMP associated bovine pumomary arterial relaxation显示文摘 | Cherry P D Omar H A Farrel K A | 1990 | Am J Physiol1990，259，： | 1 |
| 8 | A laboratory scale bioremediation of Tapis crude oil contaminated soil by bioaugmentation of Aeinetobaeter baumannii T30C 显示文摘 | Chang L K Ibrahim D Omar I C | 2011 | African Journal Of Microbiology Research2011，9，5： | 1 |
| 9 | Interaction network between frugivorous birds and zoochorous plants in cloud forest riparian strips immersed in anthropic landscapes显示文摘Worldwide,tropical montane cloud forest is one of the most important and biodiverse ecosystems;however,it is also one of those most threatened by anthropic activities.These activities lead to a fragmented,deforested landscape with narrow riparian forest strips immersed in an agricultural matrix dominated by pastures.Here,we characterize the interaction network between frugivorous birds and zoochorous plants in riparian strips of cloud forest in deforested landscapes of Central Veracruz,Mexico.To characterize the network of this mutualistic interaction,we estimated network-and species-level metrics using the Bipartite R package.Nestedness,modularity and robustness were used to describe network structure.Centrality measures of degree,closeness,betweenness centrality and their relative contribution to nestedness were used to determine the importance of each bird/plant species to the network’s structure.This interaction network has 24 species of birds and 30 species of plants,with low connectance(0.11),low nestedness(11.53),and intermediate but not significant modularity(0.49).The bird species most important to network stability were Chlorospingus flavopectus,Myadestes occidentalis,and Catharus mexicanus.The most important plants were Conostegia xalapensis,C.arborea,and Rubus ulmifolius.Network robustness varied from 0.36 to 0.86 and its stability is compromised when species of birds or plants with the highest values of centrality are removed,with plant removal more detrimental.Riparian strips of cloud forest crossing deforested areas maintain a relatively rich set of birds that disperse the seeds of many forest plants,thus they are crucial to the preservation of this mutualistic network in anthropic landscapes.Network stability is severely undermined by the loss of any of the few species—whether birds or plants—with high centrality values.The most important plants for this stability are pioneer tree and shrub species that provide food for several bird species,and they are also crucial to cloud forest regeneration.A worrisome finding is that some of the bird species most important to network stability are also among the most sought-after as ornamental birds by illegal collectors in the region. | Omar A.Hernández-Dávila Javier Laborde Vinicio J.Sosa Cecilia Díaz-Castelazo | 2022 | Avian Research2022，13，3： | 1 |
| 10 | Biofuel derived yeast protein concentrate(YPC)as a novel feed ingredi- ent in carp diets显示文摘 | OMAR S S MERRIFIELD D L KUHLWEIN H | 2012 | Aquacuhure2012，330，： | 1 |
| 11 | Studies on feeding of mirror carp(Cyprinus carpio L) in intensive aquaculture显示文摘 | Omar E A Gunther K D | 1987 | J Anim Physiol Anim Nutri1987，，57： | 1 |
| 12 | Utility of transbronchial needle aspiration in the diagnosis of endobronchial lesions显示文摘 | Asok D Prasoon J Omar A M | 1999 | Chest1999，115，5： | 1 |
| 13 | Heating rate effect on fractional yield and composition of oil retorted from El-lajjun oil shale显示文摘 | Adnan Al-Harahsheh Omar Al-Ayed Moh'd Al-Harahsheh | 2010 | Journal of Analytical and Applied Pyrolysis2010，89，： | 1 |
| 14 | Physicochemical Chamcterizatio- nand Formation of Glyphosate-laden Nano-emulsion for Herbicide Formulation 显示文摘 | Lim C J Basri M Omar D | 2012 | Industrial Crops and Products2012，36，1： | 1 |
| 15 | Physicochemical characterization and formation of glyphosate - laden nano - emulsion for herbicide formulation 显示文摘 | LIM C J BASRI M OMAR D | 2012 | Industrial Crops and Products2012，36，1： | 1 |
| 16 | Studies on feeding of mirror carp (Cyprinus carpio L) in intensive aquaculture 显示文摘 | Omar E A Gunther K D | 1987 | J Anim Physiol Anim Nutri1987，，57： | 1 |
| 17 | Exploring QSARs for inhibitory activity of non-pcptide H1V-1 protease inhibitors by GA-PLS and GA-SVM 显示文摘 | Omar D Mohammad G | 2010 | Chemical Biology & Drug Dosign2010，75，5： | 1 |
| 18 | Airway smooth muscle as an immunomodulatory cell显示文摘 | Gautam D Omar T Reynold A | 2009 | Pulm Pharmacol Ther2009，22，5： | 1 |
| 19 | Overview of the CALIPSO mission and CALIOP data processing algorithms显示文摘 | Winker D M Vaughan M A Omar A | 2009 | Atmospheric and Oceanic Technology2009，26，11： | 1 |
| 20 | Self-assembly behaviour of alkyl polyglucosides in mixed surfactant-stabilized emulsions system显示文摘 | Jiang L C Basri M Omar D | 2011 | Journal of Molecular Liquids2011，58，3： | 1 |
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