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| 1 | Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization显示文摘AIM:To evaluate the inhibitory effects of regorafenib(BAY 73-4506),a multikinase inhibitor,on corneal neovascularization(NV).METHODS:Thirty adult male Sprague-Dawley rats weighing 250-300 g,were used.Corneal NV was induced by NaOH in the left eyes of each rat.Following the establishment of alkali burn,the animals were randomized into five groups according to topical treatment.Group 1(n=6)received 0.9%NaCl,Group 2(n=6)received dimethyl sulfoxide,Group 3(n=6)received regorafenib 1 mg/mL,Group 4(n=6)received bevacizumab 5 mg/mL and Group 5(n=6)received 0.1%dexamethasone phosphate.On the 7d,the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea's total area using computer-imaging analysis.The corneas obtained from rats were semiquantitatively evaluated for caspase-3 and vascular endothelial growth factor by immunostaining.RESULTS:A statistically significant difference in the percent area of corneal NV was found among the groups(P<0.001).Although the Group 5 had the smallest percent area of corneal NV,there was no difference among Groups 3,4 and 5(P>0.005).There was a statistically significant difference among the groups in apoptotic cell density(P=0.002).The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups(P<0.05).The staining intensity of epithelial and endothelial vascular endothelial growth factor was significantly weaker in Groups 3,4 and 5 thanin Groups 1 and 2.CONCLUSION:Topical administration of regorafenib 1mg/mL is partly effective for preventing alkali-induced corneal NV in rats. | Halil Ibrahim Onder Mesut Erdurmus Yasin Yücel Bucak Hüseyin Simavli Murat Oktay Ahmet Sahap Kukner | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Numerical analysis of natural convection and radiation heat transfer from various shaped thin fin-arrays placed on a horizontal plate-a conjugate analysis 显示文摘 | DOOAN M MECIT S ONDER Y | 2014 | Energy Conversion and Management2014，77，： | 1 |
| 3 | Effect of operating parameters on selective separation of heavy metals from binary mixture via polymer enhanced ultrafiltration显示文摘 | Muslehiddinoglu J Uludag Y Onder H | 1998 | Journal of Membrane Science1998，140，： | 1 |
| 4 | A new prac- tical model of testes shield: the effectiveness during ab- dominopelvic computed tomography 显示文摘 | Sancaktutar AA Bozkurt Y Onder H | 2012 | J Androl2012，33，5： | 1 |
| 5 | Numerical analysis of naturalconvection and radiation heat transfer from various shaped thinfin-arrays placed on a horizontal plate-a conjugate analysis显示文摘 | Dogan M Mecit S Onder Y | 2014 | EnergyConversion and Management2014，77，： | 1 |
| 6 | Effect of operating parameters on selective separation of heavy metals from binary mixture via polymer enhanced ultrafihration显示文摘 | Muslehiddinoglu J Uludag Y Onder H | 1998 | J Membr Sci1998，140，2： | 1 |
| 7 | Gait speed as a marker of adverse outcomes显示文摘 | Abelian van KG Rolland Y Onder G | 2009 | J Nutr Health Aging2009，13，： | 1 |
| 8 | Chronic intestinal pseudo- obstruction and neurological manifestations in early adulthood considering MNGIE syndrome in differential diagnosis 显示文摘 | Oztas Y Ozin F Onder IK | 2010 | Journal of Gastrointestinal and Liver Diseases2010，19，2： | 1 |
| 9 | Additional cost ofhospital-acquired infection to the patient : a case study in Turkey显示文摘 | Esatoglu AE Agirbas I Onder OR Celik Y | 2006 | Health Serv Manage Res2006，19，3： | 1 |
| 10 | Effect of operating parameters on selective separation of heavy metals from binary mixture via polymer enhanced uhrafihration 显示文摘 | Muslehiddinoglu J Uludag Y Onder H | 1998 | J Memb Sci1998，140，2： | 1 |
| 11 | Reading urban spaces by the space-syntax method: A proposal for the South Halic Region显示文摘 | Onder D E Gigi Y | 2010 | Cities2010，27，4： | 1 |
| 12 | Effect of operating parameters on selective separation of heavy metals from binary mixture via polymer enhanced ultrafiltration显示文摘 | Muslehiddinoglu J Uludag Y Onder H | 1998 | J Membr Sci1998，140，2： | 1 |
| 13 | Effect of different irrigation water level on cotton yield and yield compo- nents 显示文摘 | Onder D Akiscan Y 0nder S | 2009 | African Journal of Biotechnology2009，8，8： | 1 |
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