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| 1 | p63 identifies keratinocyte stem cells 显示文摘 | Graziella P Elena D Osvaldo G | 2001 | Proc Natl Acad Sci USA2001，98，6： | 1 |
| 2 | Patch-clamp recording of charge movement,Ca21 current,and Ca21 transients in adult skeletal muscle fibers 显示文摘 | Zhong M W Marya L M Osvaldo D | 1999 | Biophysical J1999，77，11： | 1 |
| 3 | 基于G-蛋白偶联受体激酶2抑制剂治疗心力衰竭的合理药物设计(英文)显示文摘G protein-coupled receptors(GPCRs)convert extracellular stimuli in the form of hormones,odorants and light into profound changes in cell homeostasis.Their timely desensitization is critical for cells to rapidly respond to changes in their environment and to avoid damage from sustained signaling.Seven GPCR kinases(GRKs)phosphorylate and regulate the activity of most of the^800 GPCRs in the human genome.Although GRKs normally play an adaptive role,in conditions such as chronic heart failure they are overexpressed and linked to disease progression.GRK2 and GRK5 have thus become important targets for the treatment of heart failure and pathological cardiac hypertrophy,respectively.Our lab has determined atomic structures representing all three vertebrate GRK subfamilies,and is now in the midst of a campaign to develop selective inhibitors of these enzymes using structure-based rational design.We have identified the FDA approved drug paroxetine as a selective GRK2 inhibitor,determined the crystal structure of the GRK2·paroxetine complex and,in collaboration with the Koch lab,showed that the drug improves contractility in myocytes and,most impressively,recovery in postmyocardial infarcted mice.Since then,we have identified additional chemical scaffolds that exhibit even higher potency and/or selectivity for GRK5.Using a'hybrid'inhibitor design approach we have generated GRK selective chemical probes that exhibit improved potency and stability and are able to increase inotropy and dampen the hypertrophic response in cardiomyocytes and small animal models.Structural analysis has revealed the molecular basis for selectivity and potency in many of these compounds,allowing for the design of future generations of GRK chemical probes. | John J TESMER Helen V WALDSCHMIDT Marie C CATO Renee BOULEY Osvaldo CRUZ-RODRIGUEZ Scott D LARSEN | 2017 | 中国药理学与毒理学杂志2017，31，10： | 1 |
| 4 | Transit Rider- ship Forecasting at Station Level: An Approach Based on Distance-decay Weighted Regression 显示文摘 | JAVIER G OSVALDO D C JUAN C G | 2011 | Journal of Trans- port Geography2011，19，6： | 1 |
| 5 | Optical storage and surface-relief gratings in azobenzene-containing nanostructured films显示文摘 | Osvaldo N Oliveira Jr David S dos Santos Jr Débora T Balogh | 2005 | Advances in Colloid and Interface Science2005，116，： | 1 |
| 6 | Removal of Ca(II) and Mg(II) from aqueous single metal solutions by mercerized cellulose and mercerized sugarcane bagasse grafted with EDTA dianhydride (EDTAD)显示文摘 | Osvaldo Karnitz Leandro Vinícius Alves Gurgel Laurent Frédéric Gil | 2009 | Carbohydrate Polymers2009，，1： | 1 |
| 7 | Adsorption of Cu(II), Cd(II), and Pb(II) from aqueous single metal solutions by mercerized cellulose and mercerized sugarcane bagasse chemically modified with EDTA dianhydride (EDTAD)显示文摘 | Osvaldo Karnitz Júnior Leandro Vinícius Alves Gurgel Rossimiriam Pereira de Freitas Laurent Frédéric Gil | 2009 | Carbohydrate Polymers2009，，3： | 1 |
| 8 | Adsorption of heavy metal ion from aqueous single metal solution by chemically modified sugarcane bagasse显示文摘 | Osvaldo Karnitz Leandro Vinicius Alves Gurgel Júlio César Perin de Melo Vagner Roberto Botaro Tania Márcia Sacramento Melo Rossimiriam Pereira de Freitas Gil Laurent Frédéric Gil | 2006 | Bioresource Technology2006，，6： | 1 |
| 9 | Adsorption of heavy metal ion from aqueous single metal solution by chemically modified sugarcane bagasse显示文摘 | Osvaldo Karnitz Leandro Vinicius Alves Gurgel Júlio César Perin de Melo Vagner Roberto Botaro Tania Márcia Sacramento Melo Rossimiriam Pereira de Freitas Gil Laurent Frédéric Gil | 2006 | Bioresource Technology2006，，6： | 1 |
| 10 | Effectiveness and Spill- over of an After-School Health Promotion Program for Hispanic Elementary School Children 显示文摘 | Hendrik D de Heer Laura Koehly Rockie Pederson Osvaldo Morera | 2011 | American Journal of Public Health2011，101，10： | 1 |
| 11 | Persistence of oxidative stress after heart transplantation:a comparative study of patients with heart transplant versus chronic stable heart failure显示文摘 | Osvaldo P Pablo C Guillermo D A | 2002 | Rev Esp Cardiol2002，55，8： | 1 |
| 12 | Aerobic biodegradation of nonylphenol by cold-adapted bacteria 显示文摘 | ANA S BENOIT G OSVALDO D | 2003 | Biotechnology Letters2003，25，9： | 1 |
| 13 | 显示文摘 | Ana M P Osvaldo A S Marian R D | 2004 | Journal of Alloys and Compounds2004，374，： | 1 |
| 14 | FE model of beam-to-column extended end-plate joints显示文摘 | Concepción Díaz Mariano Victoria Pascual Martí Osvaldo M. Querin | 2011 | Journal of Constructional Steel Research2011，，10： | 1 |
| 15 | Multiple in- tracranial meningiomas显示文摘 | Domenicucci M Santoro A D'Osvaldo DH ct al | 1989 | J Neurosurg1989，70，1： | 1 |
| 16 | Multiple Intracraniat Meningiomas显示文摘 | Domenicucci M Santoro A D' Osvaldo DH | 1989 | J Neurosurg1989，70，1： | 1 |
| 17 | Effects of thermal, alkaline and ultrasonic treatments on scleroglucan stability and flow behavior显示文摘 | Silvana C Vi narta Osvaldo D Delgado Luc i a I C Figueroa | 2013 | Carbohydrate Polymers2013，94，： | 1 |
| 18 | p63 identifies keratinocyte stem cells显示文摘 | GRAZIEILA P ELENA D OSVALDO G | 2001 | Proc Natl Aead Sci2001，98，31： | 1 |
| 19 | Multiple intracranial meningiomas显示文摘 | Domenicucci M Santoro A D'Osvaldo DH | 1989 | J Neurosurg1989，70，： | 1 |
| 20 | Adsorption of heavy metal ion from aqueous single metal solution by chemically modified sugarcane bagasse显示文摘 | Osvaldo Karnitz Leandro Vinicius Alves Gurgel Júlio César Perin de Melo Vagner Roberto Botaro Tania Márcia Sacramento Melo Rossimiriam Pereira de Freitas Gil Laurent Frédéric Gil | 2006 | Bioresource Technology2006，，6： | 1 |
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