|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 2 | Effect of ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers显示文摘 | OUELLET D HSU A QIAN J | 1998 | Br J Clin Pharmacol1998，46，2： | 1 |
| 3 | Measurement of Normal and Shear Forces during Refining Using a Piezoelectric Force Sensor显示文摘 | Senger J J Sladat A Ouellet D | 2004 | Journal of Pulp and Paper Science2004，30，9： | 1 |
| 4 | CCN3 impairs osteoblast and stimulates osteoclast differentia- tion to favor breast cancer metastasis to bone 显示文摘 | Ouellet V Tiedemann K Mourskaia A | 2011 | Am J Pathol2011，178，5： | 1 |
| 5 | Room-temperature deposited titanium silicate thin films for MIM capacitor applications 显示文摘 | BRASSARD D OUELLET L KHAKANI M A E | | Electron Dev Lett0，28，4： | 1 |
| 6 | Outdoor tem- perature,age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-de- teeted BAT in humans显示文摘 | Ouellet V Routhier-Labadie A Bellemare W | 2011 | J Clin Endoerinol Metab2011，96，1： | 1 |
| 7 | Pharmacokinetic interaction between ritonavir and clarithromycin显示文摘 | Hshu A Granneman G R | 1998 | Clin Pharmacol Ther1998，64，4： | 1 |
| 8 | Feeding micronized and extruded flaxseed to dairy cows:effects on blood parameters and milk fatty acid composition显示文摘 | Gonthier C Mustafa A F Ouellet D R | 2005 | J Dairy Sci2005，88，： | 1 |
| 9 | Influence of diabetes mellitus onoutcome in patients over 40 years of age with the long QT syndrome显示文摘 | Ouellet G Moss A J Jons C | 2010 | Am J Cardiol2010，105，1： | 1 |
| 10 | Reservoir geomechanics for assessing containment in CO2 storage:A case study at Ketzin,Germany显示文摘 | OUELLET A BéRARD T DESROCHES J | 2011 | Energy Procedia2011，，4： | 1 |
| 11 | Potential bio- markers of preeclampsia: inverse correlation be- tween hydrogen peroxide and nitric oxide early in maternal circulation and at term in placenta of women with preeclampsia 显示文摘 | Aris A Benali S Ouellet A | 2009 | Placenta2009，30，4： | 1 |
| 12 | The wheat wcs120 promoter is cold-inducible in both monocotyle-donous and dicotyledonous species显示文摘 | Ouellet F Vazquez-Tello A Sarhan F | 1998 | FEBS Lett1998，423，： | 1 |
| 13 | Wheat EST sequence assembly facilitates comparison of gene content s among plant species and discovery of novel genes显示文摘 | HATTORI J OUELLET T TINKER N A | 2005 | Genome2005，48，2： | 1 |
| 14 | Production of the antimalarial drug precursor artemisinic acid in engineered yeast显示文摘 | Ro D K Paradise E M Ouellet M Fisher K J Newman K L Ndungu J M Ho K A Eachus R A Ham T S Kirby J Chang M C Withers S T Shiba Y Sarpong R Keasling J D | | 0，，： | 1 |
| 15 | Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans显示文摘 | OUELLET V ROUTHIER-LABADIE A BELLEMARE W | 2011 | J Clin Endocrinol Metab2011，96，1： | 1 |
| 16 | The wheat wcs120 promotet is cold-inducible in both monocotyledonous and dicotyledonous species显示文摘 | OUELLET F VAZQUEZ-TELLO A SARHAN F | 1998 | FEBS Lett1998，423，： | 1 |
| 17 | HIV-1 gpl20 induces TLR2- and TLR4- mediated innate immune activation in human female genital epithelium显示文摘 | Nazli A Kafka J K Ferreira V H Anipindi V Muel- ler K Osborne B J Dizzell S Chauvin S Mian M F Ouellet M Tremblay M J Mossman K L Ashkar A A Kovacs C Bowdish D M Snider D P Kaul R Kaushic C | 2013 | J Immunol2013，191，8： | 1 |
| 18 | Microstructural interpretation of thermal analysis of commercial 319 alloy with Mg ang Sr additions 显示文摘 | Ouellet P Samuel F H | 1997 | AFS Trans1997，105，： | 1 |
| 19 | Outdoor tem- perature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of lSF-FDG-de- tected BAT in humans显示文摘 | Ouellet V Routhier-Labadie A Bellemare W | 2011 | J Clin Endocrin Metabol2011，96，1： | 1 |
| 20 | Microstructural interpretation of thermal analysis of commercial 319 Al alloy eith Mg and Sr additions显示文摘 | SAMUEL A M OUELLET P SAMUEL F H | 1997 | AFS Transactions1997，156，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员