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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Dyslipidaemia of diabetes and the intestine显示文摘Atherosclerosis is the major complication of diabetes and has become a major issue in the provision of medical care.In particular the economic burden is growing at an alarming rate in parallel with the increasing worldwide prevalence of diabetes.The major disturbance of lipid metabolism in diabetes relates to the effect of insulin on fat metabolism.Raised triglycerides being the hallmark of uncontrolled diabetes,i.e.,in the presence of hyperglycaemia.The explosion of type 2 diabetes has generated increasing interest on the aetiology ofatherosclerosis in diabetic patients.The importance of the atherogenic properties of triglyceride rich lipoproteins has only recently been recognised by the majority of diabetologists and cardiologists even though experimental evidence has been strong for many years.In the post-prandial phase 50% of triglyceride rich lipoproteins come from chylomicrons produced in the intestine.Recent evidence has secured the chylomicron as a major player in the atherogenic process.In diabetes chylomicron production is increased through disturbance in cholesterol absorption,in particular Neimann Pick C1-like1 activity is increased as is intestinal synthesis of cholesterol through 3-hydroxy-3-methyl glutaryl co enzyme A reductase.ATP binding cassette proteins G5 and G8 which regulate cholesterol in the intestine is reduced leading to chylomicronaemia.The chylomicron particle itself is atherogenic but the increase in the triglyceride-rich lipoproteins lead to an atherogenic low density lipoprotein and low high density lipoprotein.The various steps in the absorption process and the disturbance in chylomicron synthesis are discussed. | Gerald H Tomkin Daphne Owens | 2015 | World Journal of Diabetes2015，6，7： | 2 |
| 3 | Dental transplants: Discussion and case report显示文摘 | Schuman N J Owens B M Mincer H H | 1997 | J Clin Pediatr Dent1997，21，： | 1 |
| 4 | Inactiva- tion of Cryptosporidium parvum oocysts with ozone显示文摘 | Rennecker J L Marinas B J Owens J H | 1999 | Water Re''search1999，33，11： | 1 |
| 5 | Controlling cryptosporidium using conventional treatment 显示文摘 | Dugan N R Fox K R Owens J H | 2001 | J AWWA2001，93，12： | 1 |
| 6 | Dioxin perturbs,in a dose-and timedependent fashion,steroid secretion,and induces apoptosis of human luteinized granulosa cells显示文摘 | Heimler I Rawlins R G Owen H | 1998 | Endocrinology1998，139，10： | 1 |
| 7 | Excitatory GA BA responses in embryonic and neonatal cortical slices demon strated by grarnicidin perforated- patch recordings and calei um imaging显示文摘 | Owens D F Boyce L H Davis M B | 1996 | J Neurosci1996，16，20： | 1 |
| 8 | Multiperiodic repetitive control system:A Lyapunov stability analysis for MIMO systems显示文摘 | OWENS D H LI L M BANKS S P | 2004 | International Journal of Control2004，77，5： | 1 |
| 9 | Active vibration isolation in a 'smart spring' mount using a repetitive control approach显示文摘 | Dalay S Hatonen J Owens D H | 2006 | Control Engineering Practice2006，14，9： | 1 |
| 10 | Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins显示文摘 | Huang H Sun F Owen D | 2007 | Proc Natl Acad Sci USA2007，104，14： | 1 |
| 11 | A review of the physical and chemical properties of human semen and the formulation of a semen simulant显示文摘 | Owen D H Katz D F | 2005 | J Androl2005，26，4： | 1 |
| 12 | Rare earth element geochemistry of upper Ordovician cherts from the Southern Upland of Scotland 显示文摘 | Owen A W Armstrong H A Floyd J D | 1999 | Journal of the Geological Society London1999，，156： | 1 |
| 13 | Strategic facility location: a review显示文摘 | Owen S H Daskin M S | 1998 | European Journal of Operational Research1998，111，： | 1 |
| 14 | Iterative learning control for discrete time systems with exponential rate of convergence显示文摘 | AMANN N OWENS D H ROGERS E | 1996 | IEE Proc Control Theory Appl1996，143，2： | 1 |
| 15 | Use of a new generation urban scale dispersion model to estimate the concentration of oxides of nitrogen and sulp hur dioxide in a large urban area显示文摘 | OWEN B EDMUNDS H A CARRUT H ERS D J | | 0，，1： | 1 |
| 16 | Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture显示文摘 | Cory A H Owen T C Barltrop J A | 1991 | Cancer Commun1991，3，7： | 1 |
| 17 | Feature-based re- verse engineering of mechanical parts 显示文摘 | THOMPSON W B OWEN J C JAMES H | 1999 | IEEE Transactions on Robotics and Automation1999，15，1： | 1 |
| 18 | Simulation training in emergency medicine, an important need for primary care training 显示文摘 | Mugford B Martin A Owen H | 2004 | Aust Faro Physician2004，33，4： | 1 |
| 19 | Postoperative paintherapy:a survey of patients’expectations and their experiences显示文摘 | OWEN H MCMILLAN V ROGOWSKI D | 1990 | Pain1990，41，3： | 1 |
| 20 | Strategic facility location:a review显示文摘 | Owen S H Daskin M S | 1998 | European Journal of Operational Research1998，111，： | 1 |
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