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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | Predictors of poor outcome in gastrointestinal bleeding in emergency department显示文摘AIM: To determine the prognostic risk factors of gastrointestinal bleeding in emergency department cases.METHODS: The trial was a retrospective single-center study involving 600 patients over 18-years-old and carried out with approval by the Institutional Ethics Committee. Patient data included demographic characteristics, symptoms at admission, past medical history, vital signs, laboratory results, endoscopy and colonoscopy results, length of hospital stay, need of intensive care unit(ICU) admission, and mortality. Mortality rate was the principal endpoint of the study, while duration of hospital stay, required interventional treatment, and admission to the ICU were secondary endpoints.RESULTS: The mean age of patients was 61.92-yearsold. Among the 600 total patients, 363(60.5%) underwent upper gastrointestinal endoscopy and the most frequent diagnoses were duodenal ulcer(19.2%) and gastric ulcer(12.8%). One-hundred-and-fifteen(19.2%) patients required endoscopic treatment, 20(3.3%) required surgical treatment, and 5(0.8%) required angiographic embolization. The mean length of hospital stay was 5.21 ± 5.85 d. The mortality rate was 6.3%. The ICU admission rate was 5.3%. Patients with syncope, higher blood glucose levels, and coronary artery disease had significantly higher ICU admission rates(P = 0.029, P = 0.043, and P = 0.002, respectively). Patients with low thrombocyte levels, high creatinine, high international normalized ratio, and high serum transaminase levels had significantly longer hospital stay(P = 0.02, P = 0.001, P = 0.019, and P = 0.005, respectively). Patients who died had significantly higher serum blood urea nitrogen and creatinine levels(P = 0.016 and P = 0.038), and significantly lower mean blood pressure and oxygen saturation(P = 0.004 and P = 0.049). Malignancy and low Glasgow coma scale(GCS) were independent predictive factors of mortality.CONCLUSION: Prognostic factors for gastrointestinal bleeding in emergency room cases are malignancy, hypotension on admission, low GCS, and impaired kidney function. | Ender Kaya Mehmet Ali Karaca Deniz Aldemir M Mahir Ozmen | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 3 | Staging laparoscopy for gastric cancer, surgical laparoscopy显示文摘 | Ozmen M Mahir MD MS | 2003 | Endoscopy & Percu taneous Techniques2003，13，4： | 1 |
| 4 | Bone mineral density in children with neurofibromatosis l显示文摘 | Yilmaz K Ozmen M Goksan SB | 2007 | Acta Padiatrica2007，96，8： | 1 |
| 5 | Percutaneous transeatheter ethanol selerotherapy and catheter drainage of postoperative pelvic lymphoceles 显示文摘 | Akhan O Karcaaltincaba M Ozmen MN | 2007 | Cardiovasc Intervent Ra- diol2007，30，： | 1 |
| 6 | Freezing as a path to build macroporous structures: Superfast responsive polyacrylamide hydrogels显示文摘 | Dinu M V Ozmen M M Dragan E S | 2007 | Polymer2007，48，1： | 1 |
| 7 | Use offl-Cyclodextrin and Starch Based Polymers for Sorption of Congo Red from Aqueous Solu- tions显示文摘 | Ozmen E Y Yilmaz M | 2007 | JHazardMater2007，148，12： | 1 |
| 8 | Clinicopathological studies on facial eczema out- break in sheep in Southwest Turkey显示文摘 | OZMEN O SAHINDURAN S HALIGUR M et al | 2008 | Trop Anita Health Prod2008，40，10： | 1 |
| 9 | Current aspects of blastocyst cryopreservation显示文摘 | Youssry M Ozmen B Zohni K | 2008 | Reprod Biomed Online2008，16，2： | 1 |
| 10 | Synthesis of β-eyelodextrin and starch based polymers for sorption of azo dyes from aqueous solutions显示文摘 | Ozmen E Y Sezgln M Yilmaz A | 2008 | Bioresource Technol2008，99，3： | 1 |
| 11 | Increased thickness of the carotid artery intima-media assessed by ultrasonography in Behcet's disease显示文摘 | Keser G Aksu K Tamsel S Ozmen M Kitapcioglu G Kabaroglu C | 2005 | Clin Exp Rheumatol2005，23，438： | 1 |
| 12 | Highaffinity receptor for interferon-gamma (IFN-gamma),a ubiquitous protein occurring in different molecular forms on human cells:blood monocytes and eleven different cell lines have the same IFN-gamma receptor protein 显示文摘 | van Loon A P Ozmen L Fountoulakis M | 1991 | J Leukoc Biol1991，49，5： | 1 |
| 13 | Long-term results of single- session percutaneous drainage and ethanol sclerotherapy in simple renal cysts显示文摘 | Akinci D Akhan O Ozmen M | 2005 | Eur J Radio12005，54，2： | 1 |
| 14 | Serum cystatin C level as a potentially good marker for impaired kidney function显示文摘 | Uzun H Ozmen Keles M Ataman R | 2005 | Clin Biochem2005，38，9： | 1 |
| 15 | Prognostic significance of ischemia-modified albumin in patients with acute coronary syndrome显示文摘 | Aparci M Kardesoglu E Ozmen N | | 0，，05： | 1 |
| 16 | Axillary sentinel node biopsy after neoadjuvant chemotherapy显示文摘 | Ozmen V Unal E S Muslumanoglu M E Igci A Canbay E Ozcinar B | 2010 | Eur J Surg Oncol2010，36，： | 1 |
| 17 | Percutaneous transcatheter ethanol sclerotherapy and catheter drainage of postoperative pelvic lymphoceles显示文摘 | Akhan O Karcaaltincaba M Ozmen MN | 2007 | Cardiovasc Intervent Radiol2007，30，3： | 1 |
| 18 | Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain显示文摘 | Kahle PJ Neumann M Ozmen L | 2000 | J Neurosci2000，20，17： | 1 |
| 19 | Dehydroepiandrosterone supplementation improves ovarian response and cycle outcome in poor responders显示文摘 | Sonmezer M Ozmen B Cil A P | 2009 | Reprod Biomed Online2009，19，4： | 1 |
| 20 | Prognostic significance of ischemia modified albumin in patients with acute coronary syn2drome显示文摘 | Aparci M Kardesoglu E Ozmen N | 2007 | Coron Artery2007，18，5： | 1 |
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