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73篇 您的检索式:作者名="Obach RS"
    题名 作者 年代 出处 被引量
1Metabolic activation in drug-induced liver injury显示文摘Leung L Kalgutkar AS Obach RS 2012Drug Metab Rev2012,44,1:1
2The impact of P - glycoprotein on the drug targeted for indications of the central nervous system evaluation using the MDR1A/1B knock out mouse model显示文摘Doran A Obach RS Smith BJ 2005Drug Metab Dispos2005,33,:1
3Metabolism and disposition of varenicline,a selective alpha4beta2 acetylcholine receptor partial agonist,in vivo and in vitro显示文摘Obach RS Reed-Hagen AE Krueger SS 2006Drug Metab Dispos2006,34,1:1
4Metabolism and disposition of varenicline,a selective alpha4beta2 acetylcholine receptor partial agonist,in vivo and in vitro显示文摘Obach RS Reed-Hagen AE Krueger SS 2005Drug Metab Dispos2005,34,1:1
5Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug comt)ounds显示文摘Obach RS Lombardo F Waters NJ 2008Drug Metab Dispos2008,36,7:1
6Effect of human renal cationic transporter inhibition on the pharmacokinetics of varenicline,a new therapy for smoking cessation:an in vitro-in vivo study显示文摘Feng B Obach RS Burstein AH 2008Clin Pharmacol Ther2008,83,4:1
7Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm 显示文摘Ito K Hallifax D Obach RS 2005Drug Metab Dispos2005,33,6:1
8Effect of human renal cationic transporter inhibition on the pharmacokinetics of vareniciine,a new therapy for smoking cessation:An in vitro-in vivo study显示文摘Feng B Obach RS Burstein AH 2008Clin Pharmacol Ther2008,83,4:1
9A hy- brid mixture discriminant analysis random forest computational model for the prediction of volume of distribution of drugs in human显示文摘Lombardo F Obach RS DiCapua FM 2006J Med Chem2006,49,7:1
10Validated assays for human cytochrome P450 activities显示文摘Walsky RL Obach RS 2004Drug Metab Dispos2004,32,6:1
11Mechanismbased inactivation of human cytochrome P450 enzymes and the prediction of drug-drag interactions 显示文摘Obach RS Walsky RL Venkatakrishnan K 2007Drug Metab and dispos2007,35,2:1
12Selectiveinhibition of human cytochrome P4502C8by monte-lukast显示文摘Walsky RL Obach RS Gaman EA 2005Drug Metab Dispos2005,33,3:1
13Examination of 209 drugs for inhibition of cytochrome P450 2C8显示文摘WALSKY RL GAMAN EA OBACH RS 2005J Clin Pharmacol2005,45,1:1
14The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data显示文摘Obach RS Baxter JG ListonTE 1997J Pharmacology Experimental Therapeutics1997,283,1:1
15Se- lective inhibition of human cytochrome P4502C8 by montelukast 显示文摘Walsky RL Obach RS Gaman EA Gleeson JP Proctor WR 2005Drug Metab Dispos2005,33,3:1
16The impact of P - glycoprotein on the disposition of drugs targeted for indications of the central nervous system : evaluation using the MDR1A/1B knockout mouse model 显示文摘Doran A Obach RS Smith BJ 2005Drug Metab Dispos2005,33,:1
17Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes 显示文摘Obach RS 1999Drug Metab Dispos1999,27,:1
18The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions显示文摘Obach RS Walsky RL Venkatakrishnan K 2006J Pharmacol Exp Ther2006,316,1:1
19In vitro cytoehrome P450 inhibition data and the prediction of Drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach 显示文摘Obach RS Walsky RL Venkatakrishnan K 2005Clin Pharmacol Ther2005,78,6:1
20Drug metabolism and drug interactions: application and clinical value of in vitro models 显示文摘VENKATAKRISHNAN K VON MOLTKE LL OBACH RS 2003Curr Drug Metab2003,4,5:1
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