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| 1 | Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats显示文摘AIM:To investigate the effects of resveratrol on liver ischemia/reperfusion (I/R) injury in rats. METHODS: A total of 40 male Sprague-Dawley rats weighing 240-290 g were randomized into four groups of ten: (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) I-R/Resveratrol group: rats pretreat- ed with resveratrol (10 μmol/L,iv). Liver tissues wweerre obtained to determine antioxidant enzyme levels and for biochemical and histological evaluation. RESULTS: Plasma aminotransferase activities were higher in the I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase ,and glutathione peroxidase levels increased in group 4 compared to group 3. In group 4, histopathological changes were significantly attenuated in resveratrol-treated livers. CONCLUSION: These results suggest that resveratrol has protective effects against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusion-related liver injury. | Ercan Gedik Sadullah Girgin Hayrettin Ozturk Basra Deniz Obay Hulya Ozturk Huseyin Buyukbayram | 2008 | World Journal of Gastroenterology2008，14，46： | 14 |
| 2 | Artificial intelligence in gastroenterology: A state-of-the-art review显示文摘The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical specialties.The field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an exception.The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic examination.The objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field. | Paul T Kröner Megan ML Engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik Jeanin E van Hooft Michael B Wallace Hashem B El-Serag Chayakrit Krittanawong | 2021 | World Journal of Gastroenterology2021，27，40： | 6 |
| 3 | Identificationofgenesrelatedtomechanicalstressinhumanperiodontalligamentcellsusingmicroarrayanalysis显示文摘 | deAraujoRM ObaY MoriyamaK | 2007 | JPeriodontalRes2007，42，1： | 1 |
| 4 | Volar fixed-angle plate fixation for unstable distal radius factures in the elderly patient 显示文摘 | Obay J Femandez D L | 2004 | J Hand Surg Am2004，29，1： | 1 |
| 5 | Almost Periodic Type Solutions of Differential equations with Piecewise Constant Argument via Almost Periodic Type Sequences 显示文摘 | Alonso A I Hong J L Obay A R | 2000 | Appl Math Lett2000，13，： | 1 |
| 6 | Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model显示文摘 | TASDEMIR E TUMER C | 2008 | Peptides2008，29，3： | 1 |
| 7 | The hepatoprotective effect of counmarin and eoumarin derivates on carbon tetrachloride induced hepatic injury by antioxidative activities in rats显示文摘 | Atmaca M Bilgin H M Obay B D | 2011 | J Physiol Biochem2011，67，： | 1 |
| 8 | Dose dependent effects of ghre- lin on pentylenetetrole-induced oxidative stress in a ral seizure model显示文摘 | Obay BD Tasdemir E Ttimer C | 2008 | Peptides2008，29，3： | 1 |
| 9 | Effect of ghrelin administration on phagocytic activity in acute cold-restraint stress exposed rats显示文摘 | TüMER C BILGIN H M OBAY B D | 2007 | Regul Pept2007，138，23： | 1 |
| 10 | roflumilast in patients Efficacy and safety of with chronic obstructive pulmonary disease: a systematic review and recta- analysis显示文摘 | OBAY LONE N A | 2013 | Ther Adv Respir Dis2013，7，1： | 1 |
| 11 | Antiepileptic effects of ghrelin on pentylenetetrazole - induced seizures in rats 显示文摘 | Obay BD Tasdemir E Tumer C | 2007 | Peptides2007，28，： | 1 |
| 12 | Effect of nitric oxide on phagocytic activity of lipopolysaccharide-induced macrophages:possible role of exogenous L-arginine显示文摘 | Tumer C Bilgin HM Obay BD | 2007 | Cell Biol Int2007，31，6： | 1 |
| 13 | Protective effects of coumarin and coumarin derivatives against Carbon tetrachloride-induced acute hepatotoxicity in rats 显示文摘 | Murat Bilgin H Atmaca M Deniz Obay B | 2011 | Exp Toxi- colPathol2011，63，4： | 1 |
| 14 | The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats 显示文摘 | Atmaca M Bilgin H M Obay B D | 2011 | J Physiol Biochem2011，67，： | 1 |
| 15 | LAMP using a disposable pocket warmer for anthrax detection, a highly mobile and reliable method for anti bioterrorism显示文摘 | Hatano B Maki T Obai'a T | 2010 | Jpn J Infect Dis2010，63，1： | 1 |
| 16 | CO2, NOx and SO2 e missions from the combustion of coal with high oxygen con- centration gases显示文摘 | HU Y NATIO S OBAY ASHI N | 2000 | Fuel2000，79，15： | 1 |
| 17 | The hepatoprolective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats显示文摘 | Atmaca M Bilgin HM Obay BD | 2011 | J Physiol Biochem2011，67，： | 1 |
| 18 | Overlapping functions of YDA and MAPKKK3/MAPKKK5 upstream of MPK3/MPK6 in plant immunity and growth/development显示文摘Arabidopsis MITOGEN-ACTIVATED PROTEIN KINASE3(MAPK3 or MPK3)and MPK6 play important signaling roles in plant immunity and growth/development.MAPK KINASE4(MKK4)and MKK5 function redundantly upstream of MPK3 and MPK6 in these processes.YODA(YDA),also known as MAPK KINASE KINASE4(MAPKKK4),is upstream of MKK4/MKK5 and forms a complete MAPK cascade(YDA–MKK4/MKK5–MPK3/MPK6)in regulating plant growth and development.In plant immunity,MAPKKK3 and MAPKKK5 function redundantly upstream of the same MKK4/MKK5–MPK3/MPK6 module.However,the residual activation of MPK3/MPK6 in the mapkkk3 mapkkk5 double mutant in response to flg22 pathogen-associated molecular pattern(PAMP)treatment suggests the presence of additional MAPKKK(s)in this MAPK cascade in signaling plant immunity.To investigate whether YDA is also involved in plant immunity,we attempted to generate mapkkk3 mapkkk5 yda triple mutants.However,it was not possible to recover one of the double mutant combinations(mapkkk5 yda)or the triple mutant(mapkkk3 mapkkk5 yda)due to a failure of embryogenesis.Using the clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPRassociated protein 9(Cas9)approach,we generated weak,N-terminal deletion alleles of YDA,yda-del,in a mapkkk3 mapkkk5 background.PAMP-triggered MPK3/MPK6 activation was further reduced in the mapkkk3 mapkkk5 yda-del mutant,and the triple mutant was more susceptible to pathogen infection,suggesting YDA also plays an important role in plant immune signaling.In addition,MAPKKK5 and,to a lesser extent,MAPKKK3 were found to contribute to gamete function and embryogenesis,together with YDA.While the double homozygous mapkkk3 yda mutant showed the same growth and development defects as the yda single mutant,mapkkk5 yda double mutant and mapkkk3 mapkkk5 yda triple mutants were embryo lethal,similar to the mpk3 mpk6 double mutants.These results demonstrate that YDA,MAPKKK3,and MAPKKK5 have overlapping functions upstream of the MKK4/MKK5–MPK3/MPK6 module in both plant immunity and growth/development. | Yidong Liu Emma Leary Obai Saffaf RFrank Baker Shuqun Zhang | 2022 | Journal of Integrative Plant Biology2022，64，8： | 0 |
| 19 | Equal Partnership in Agriculture显示文摘It was wonderful to be back in China in June for the Third China-Africa Economic and Trade Expo(CAETE)in the city of Changsha,Hunan Province.Since its inauguration in 2019,the CAETE has become an important platform for expanding the China-Africa relationship,of which agricultural cooperation is an increasingly significant element.The scale of the activities in Changsha was testament to the scope and ambition of all those involved in China-Africa exchanges. | Obai Khalifa | 2023 | Beijing Review2023，66，43： | 0 |
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