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| 1 | Novel therapy for non-cirrhotic hyperammonemia due to a spontaneous splenorenal shunt显示文摘Spontaneous splenorenal shunts in the absence of cirrhosis have rarely been reported as a cause hyperammonemia with encephalopathy. Several closure techniques of such lesions have been described. Here we report a case of a patient with no history of liver disease who developed significant confusion. After an extensive workup, he was found to have hyperammonemia and encephalopathy due to formation of a spontaneous splenorenal shunt. There was no evidence of cirrhosis on biopsy or imaging and no portal hypertension when directly measured. The shunt was 18 mm and too large for embolization so the segment of the splenic vein between the portal vein and the shunt was occluded using an Amplatzer plug. Thus, the superior mesenteric flow was directed entirely to the liver. After interventional radiology closure of the shunt using this technique there was complete resolution of symptoms.The case represents the first report of a successful closure of splenorenal shunt via percutaneous embolization of the splenic vein with an amplatzer plug using a common femoral vein approach. | Shari S Rogal Angela Hu Rupal Bi Obaid Shaikh | 2014 | World Journal of Gastroenterology2014，20，25： | 5 |
| 2 | Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation显示文摘Selective cyclooxygenase-2 (COX-2) inhibitors are widely used due to their efficacy and good safety profile. However, recent case reports have described varying degrees of liver injuries associated with the use of COX-2 inhibitors. We report the case of a patient who developed acute cholestatic hepatitis progressing to hepatic failure requiring liver transplantation, following a 3-d course of celecoxib for treatment of generalized muscle aches and pains. The clinical presentation, the laboratory data, as well as the liver histopathology were supportive of the putative diagnosis of drug induced liver injury. | Ihab I El Hajj Shahid M Malik Hany R Alwakeel Obaid S Shaikh Eizaburo Sasatomi Hossam M Kandil | 2009 | World Journal of Gastroenterology2009，15，31： | 4 |
| 3 | Anterior surgical interventions in spinal tuberculosis 显示文摘 | Obaid ur Rahman Ahmad S Hussain T | 2009 | J Coll Physicians Surg Pak2009，19，8： | 1 |
| 4 | Alcoholic hepatitis 显示文摘 | David A Obaid S | 2006 | Clin Liver Dis2006，10，2： | 1 |
| 5 | Formation and characterization of surfactant stabilized silver nanoparticles:a kinetic study显示文摘 | AL-THABAITI S A AL-NOWAISER F M OBAID A Y | | 0，，02： | 1 |
| 6 | Shape-di- recting role of cetyltrimethylammonium bromide on the morphology of extracellular synthesis of silver nanoparti- cles 显示文摘 | Al-Thabait SAi Obaid A Y Hussain S | 2015 | Arabian Journal of Chemistry2015，8，4： | 1 |
| 7 | Retrospective review of total neoadjuvant therapy显示文摘BACKGROUND Neoadjuvant chemoradiotherapy(nCRT)followed by resection and postoperative multi-agent chemotherapy(maChT)is the standard of care for locally advanced rectal cancer.Using this approach,maChT administration can be delayed for several months,leading to concern for distant metastases.To counteract this,a novel treatment approach known as total neoadjuvant therapy(TNT)has gained popularity,in which patients receive both maChT and nCRT prior to resection.We utilized the National Cancer Database to examine temporal trends in TNT usage,and any potential effect on survival.AIM To study the temporal trends in the usage of TNT and evaluate its efficacy compared to neoadjuvant chemoradiation.METHODS We queried the National Cancer Database for patients with locally advanced rectal cancer,Stage II-III,from 2004-2015 treated with nCRT or TNT.TNT was defined as maChT initiated≥90 d prior to nCRT initiation.Overall survival was calculated from the date of diagnosis to the date of last contact or death using Kaplan-Meier curves to present the cumulative probability of survival,with logrank statistics to assess significance.Multivariable cox regression was used to identify predictors of survival and propensity score analysis accounted for bias.RESULTS We identified 9066 eligible patients,with 8812 and 254 patients receiving neoadjuvant chemoradiation followed by maChT and TNT,respectively.Nodal involvement,stage III disease,and treatment in recent years were predictive of TNT use.There was greater use of TNT with more advanced stage,specifically>1 node involved(odds ratio[OR]=2.88,95%confidence interval[CI]:2.11-3.93,P<0.01)and stage III disease(OR=2.88,95%CI:2.11-3.93,P<0.01).From 2010 to 2012 the use of TNT increased(OR=2.41,95%CI:1.27-4.56,P<0.01)with a greater increase from 2013 to 2015(OR=6.62,95%CI:3.57-12.25,P<0.01).Both the TNT and neoadjuvant chemoradiation arms had a similar 5-year survival at 76%and 78%respectively.Multivariable analysis with propensity score demonstrated that increased age,high comorbidity score,higher grade,African American race,and female gender had worse overall survival.CONCLUSION Our data demonstrates a rising trend in TNT use,particularly in patients with worse disease.Patients treated with TNT and nCRT had similar survival.Randomized trials evaluating TNT are underway. | Laila Babar Veli Bakalov Stephen Abel Obaid Ashraf Gene Grant Finley Moses S Raj Kristina Lundeen Dulabh K Monga Alexander V Kirichenko Rodney E Wegner | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 1 |
| 8 | Exact analytical formula for Voio spectral line profile显示文摘 | ROSTON G D OBAID F S | 2005 | Journal of Quantitative Spectroscopy and Radiative Transfer2005，94，2： | 1 |
| 9 | Uropathogenic Escherichia coli isolates with different virulence genes content exhibit similar pathologic influence on Vero cells显示文摘 | Obaid J M Mansour S R Elshahedy M S | 2014 | Pol J Microbiol2014，63，1： | 1 |
| 10 | Anterior surgical inter-ventions in spinal tuberculosis 显示文摘 | Obaid R Ahmad S Hussain T | 2009 | Coll Physicians SurgPak2009，19，8： | 1 |
| 11 | Fabrication and characterisations of n-CdS/p-PbS heterojunction solar cells using microwave-assisted chemical bath deposition 显示文摘 | OBAID A S HASSAN Z MAHDI M A | 2013 | Sol Energy2013，89，2： | 1 |
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