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| 1 | Seasonal variation for the antidiabetic activity of Loranthus micranthus methanol extract显示文摘Objective:To determine the season in which the Eastern Nigeria mistletoe,Loranthus micranthus,parasitic on Persea americana possesses optimum antidiabetic activity and to determine the seasonal variation in the constituents.Methods:The antidiabetic activities of the aqueous methanol extracts of the leaves of Eastern Nigeria mistletoe,Loranthus micranthus, harvested in two seasons of the year,the onset of rainy season(April) and the peak of rainy season(July) were compared.The tests were carried out on six(6) groups(A-F) of alloxaninduced diabetic rats.Groups A and B received 200 mg/kg and 400 mg/kg of the April sample extracts respectively while groups C and D received same doses of the July sample extracts. Group E and F which were the positive and negative controls received 10 mg/kg of glibenclamide and 2 ml/kg of 3%tween 20 respectively.The blood glucose levels of the animals were monitored hourly with a glucometer for six hours.The phytochemical analysis of the plant extracts were also carried out by standard procedures.Results:The results showed that group A and B exhibited significant(P<0.05) percentage reduction in the fasting blood sugar(FBS) level of the animals(38.9%and 39.2%respectively) with maximum reduction observed at the 5th and 6th hour respectively compared to glibenclamide(71.3%).Group C showed no significant (P>0.05) FBS reduction(15.9%) while group D exhibited highly significant(P<0.01) reduction (47.5%) with the maximum reduction occurring after 6 hours.The phytochemical analysis of the crude methanol extracts revealed the presence of carbohydrates,glycosides,saponins, tannins,flavonoids,steroids,terpenoids,acidic compounds,resins and oils.These were present in different proportions in both seasons.Conclusions:This study shows that there is a seasonal, dose-dependent variation in the chemical composition viz-a-viz the antidiabetic activity of the plant under study.This activity is highest at the peak of the rainy season. | Patience Ogoamaka Osadebe Edwin Ogechukwu Omeje Philip Felix Uzor Ernest Kenechukwu David Damian Chiedozie Obiorah | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，3： | 4 |
| 2 | Primary mucosa-associated lymphoid tissue lymphoma of the liver: A report of two cases and review of the literature显示文摘Mucosa-associated lymphoid tissue(MALT) lymphoma of the liver is a very rare condition and thus the diag-nosis may be challeng-ing-. The clinical presentation is usually variable, rang-ing- from minimal clinical symptoms to severe end stag-e liver disease. In this paper, we describe the clinicopatholog-ic finding-s in two cases of primary hepatic MALT lymphoma. One case is an 80-year-old female with no underlying- chronic liver disease and the second case is a 30-year-old female with autoimmune hepatitis complicated by MALT lymphoma. In both specimens, there was diffuse infiltration of atypical B-lymphocytes that were positive for CD20 and CD79 a, but neg-ative for CD5, CD43 and CD10. There were occasional lymphoepithelial lesions involving- the hepatocytes or bile ducts. Polymerase chain reaction analysis showed monoclonal immunog-lobulin heavy chain g-ene rearrang-ement in both cases. The first case was treated with surg-ery but developed pulmonary recurrence a year after complete resection but went into remission following- treatment with rituximab. A second recurrence occurred in the rig-ht parotid g-land 7 years later, which was treated with idelalisib. The second case was effectively treated with rituximab. To our knowledg-e, the second case is the first reported case linked to autoimmune hepatitis. | Ifeyinwa E Obiorah Lynt Johnson Metin Ozdemirli | 2017 | World Journal of Hepatology2017，9，3： | 4 |
| 3 | Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells显示文摘 | S Sengupta I Obiorah PY Maximov R Curpan VC Jordan | 2013 | Br J Pharmacol2013，，1： | 1 |
| 4 | Breast Cancer Cell Apoptosis with Phytoestrogens Is Dependent on an Estrogen-Deprived State 显示文摘 | Obiorah IE Fan P Jordan VC | 2014 | Cancer Prevention Research2014，7，9： | 1 |
| 5 | Evolution of long-term adjuvant anti-hormone therapy: consequences and opportunities 显示文摘 | Jordan VC Obiorah I Fan P | 2011 | Breast2011，20，3： | 1 |
| 6 | Progress in endocrine approaches to the treatment and prevention of breast cancer显示文摘 | Ifeyinwa Obiorah V. Craig Jordan | 2011 | Maturitas2011，，4： | 1 |
| 7 | Neural stem cell apoptosis after low-methylmercury exposures in postnatal hippocampus produce persistent cell loss and adolescent memory deficits显示文摘 | Sokolowski K Obiorah M Robinson K | 2013 | Developmental Neurobiology2013，73，12： | 1 |
| 8 | Progress in endocrine approaches to the treatment and prevention of breast cancer 显示文摘 | Obiorah I Jordan V C | 2011 | Maturitas2011，70，4： | 1 |
| 9 | Progress in endocrine approaches to the treatment and prevention of breast cancer显示文摘 | Obiorah I Jordan V C | 2011 | Matu- ritas2011，70，4： | 1 |
| 10 | Clear cell sarcoma in unusual sites mimicking metastatic melanoma显示文摘BACKGROUND Clear cell sarcoma is an aggressive rare malignant neoplasm with morphologic and immunohistochemical similarities to malignant melanoma.Both disease entities display melanin pigment and melanocytic markers,making differentiation between the two difficult.Although clear cell sarcoma cases in the literature have mainly involved deep soft tissues of the extremities,trunk or limb girdles,we report here two cases of primary clear cell sarcoma in unusual sites and describe their clinicopathologic findings.CASE SUMMARY The first case involves a 37-year-old female,who presented with jaw pain and a submandibular mass.The second case involves a 33-year-old male,who presented with back pain and a thoracic spine tumor.Both cases showed tumors with diffuse infiltration of neoplastic cells that were positive for melanocytic markers,and in both cases this finding led to an initial diagnosis of metastatic melanoma.However,further analysis by fluorescence in situ hybridization(commonly known as FISH)showed a rearrangement of the EWS RNA binding protein 1(EWSR1)gene on chromosome 22q12 in both patients,confirming the diagnosis of clear cell sarcoma.CONCLUSION Distinction between clear cell sarcoma and malignant melanoma can be made by FISH,particularly in cases of unusual tumor sites. | Ifeyinwa E Obiorah Metin Ozdemirli | 2019 | World Journal of Clinical Oncology2019，10，5： | 0 |
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