|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Ocular and systemic factors relevant to diabetic keratoepitheliopathy显示文摘 | Inoue K Kato S Ohara C | 2001 | Comen2001，20，8： | 1 |
| 3 | Elevated Ig G4concentrations in serum of patients with Mikulicz’s disease显示文摘 | Yamamoto M Ohara M Suzuki C | 2004 | Scand J Rheumatol2004，33，6： | 1 |
| 4 | Elevated IgG4 concentrations in serum of patients with Mikulicz's disease 显示文摘 | Yamamoto M Ohara M Suzuki C | 2004 | Scand J Rheumatol2004，33，6： | 1 |
| 5 | Phasing the mirror segments of the Keck telescopes 1I: the narrow--band phasing algorithm显示文摘 | Chanan G Ohara C Troy M | 2000 | Applied Optics2000，39，25： | 1 |
| 6 | Phasing the mirror segments of the Keck telescopes Ⅱ:the narrow-band phasing algorithm显示文摘 | CHANAN G OHARA C TROY M | 2000 | Applied Optics2000，39，25： | 1 |
| 7 | Global existence and gradientestimates for quasilinear parabolic equations of the m-Laplacian type with a strong perturbation显示文摘 | CHEN C NAKAO M OHARA Y | 2000 | Adv Math Sci Appl2000，10，1： | 1 |
| 8 | Experimental verification of dispersed fringe sensing as a segment phasing technique using the Keck telescope显示文摘 | Sill F CHANAN G OHARA C | 2004 | Applied Optics2004，43，23： | 1 |
| 9 | Metastatic interdigitating dendritic cell sarcoma masquerading as a skin primary tumor: a case report and review of the literature显示文摘 | Lee J C Christensen T OHara C J | 2009 | Am J Dermatopathol2009，31，1： | 1 |
| 10 | Ocular and systemic factors relevant todiabetic keratoepitheliopathy 显示文摘 | Inoue K Kato S Ohara C | 2001 | Cornea2001，20，8： | 1 |
| 11 | X-ray phase imaging using a X-ray tube with a small focal spot improvement of image quality in mammography 显示文摘 | Honda C Ohara H Ishisaka A | 2002 | Igaku Butsuri2002，22，1： | 1 |
| 12 | Acute and sublethal toxicity of naphthalene and three methylated derivatives to the estuarine copepod, Eurytemoraaffinis显示文摘 | OTT F S HARRIS P OHARA S C M | 1978 | Marine Environ Res1978，，1： | 1 |
| 13 | Elevated IgG4concentrations in serum of patients with Mikulicz's disease显示文摘 | Yamamoto M Ohara M Suzuki C | 2004 | Scand J Rheumatol2004，33，43： | 1 |
| 14 | Characterization of the physical and molecular structure of thermally elongation poly (ethylene terephthalate) fibers 显示文摘 | Donnelly A Ohara T Birkinshaw C | 1997 | Journal of Applied Polymer Science1997，66，： | 1 |
| 15 | Interplay between hole instability and nanoparticle array formation in ultrathin liquid films显示文摘 | Gelbart W M Ohara P C | 1998 | Langmuir1998，14，： | 1 |
| 16 | Thermodynamic control of gold nanocrystal size: Experiment and theory 显示文摘 | Leff D V Ohara P C Heath J R | 1995 | J Phys Chem1995，99，18： | 1 |
| 17 | Successful surgical treatment of verrucous haemangioma:a combined approach显示文摘 | Yang C H Ohara K | 2002 | Dermatol Surg2002，28，10： | 1 |
| 18 | Self-assembly of submicrome- ter rings of particles from solutions of nanopartieles显示文摘 | Ohara P C Heath J R Gelbart W M | 1997 | Angew Chem Int Ed1997，36，10： | 1 |
| 19 | Ocular and systemic factors relavent to diabetic keratoepitheliaopathy显示文摘 | Kato S Ohara C | 2001 | Cornea2001，20，8： | 1 |
| 20 | Phasing the mirror segments of the Keck telescopes II: the narrow-band phasing algorithm 显示文摘 | Chanan G Ohara C Troy M | 2000 | Appl Opt2000，39，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员