|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of targeted therapy in metastatic colorectal cancer显示文摘Colorectal cancer(CRC) is a significant cause of cancer-related morbidity and mortality all over the world.Improvements of cytotoxic and biologic agents have prolonged the survival in metastatic CRC(mC RC),with a median overall survival of approximately 2 years and more in the past two decades.The biologic agents that have proven clinical benefits in m CRC mainly target vascular endothelial growth factor(VEGF) and epidermal growth factor receptor(EGFR).In particular,bevacizumab targeting VEGF and cetuximab and panitumumab targeting EGFR have demonstrated sig-nificant survival benefits in combination with cytotoxic chemotherapy in the first-line,second-line,or salvage setting.Aflibercept,ramucirumab,and regorafenib are also used in second-line or salvage therapy.Recent retrospective analyses have shown that KRAS or NRAS mutations were negative predictive markers for anti-EGFR therapy.Based on the evidence from large rand-omized clinical trials,personalized therapy is necessary for patients with m CRC according to their tumor biology and characteristics.The aim of this paper was to summarize the results of the major randomized clinical trials and highlight the benefits of the molecular targeted agents in patients with mC RC. | Yoshihito Ohhara Naoki Fukuda Satoshi Takeuchi Rio Honma Yasushi Shimizu Ichiro Kinoshita Hirotoshi Dosaka-Akita | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 8 |
| 2 | Cardiovascular effects of the new cardiotonic agent 1,2-dihydro-6-methyl-2-oxo-5-(imidazopyridin-6-yl)-3-pyridine carbonitrile hydrochloride monohydrate显示文摘 | Ogawa T Takeda M | 1989 | Drugs Res1989，39，： | 1 |
| 3 | Combination of ethylbenzene dehydrogenation and carbon dioxide shift-reaction over a sodium oxide/alumina catalyst显示文摘 | Ohhara M Sodesawa T | 1988 | Appl Catal1988，37，： | 1 |
| 4 | Antimetastasis effect of PSK, a protein-bound polysaccharide, against the B16-BL6mouse melanoma显示文摘 | Ohhara M Oguchi Y | 1996 | Invas Metast1996，16，1： | 1 |
| 5 | Imperfections and Their Influences on Optical Homogeneity of PbMoO4 Single Crystal Grown by Czochralski Method 显示文摘 | Satoh T Ohhara A Fujii N | 1974 | Journal of Crystal Growth1974，2425，： | 1 |
| 6 | Activation but not inactivation of the MTS1 gene is associated with primary colorectal carcinomas显示文摘 | Ohhara M Esumi M Kurosu Y | 1996 | Biochem Biophys Res Commun1996，226，3： | 1 |
| 7 | Imperfections and Their Influences on Optical Homogeneity of PbMoO4 Single Crystal Grown by Czohralski Method显示文摘 | Satoh T Ohhara A Fujii N et a1 | 1974 | J Cryst Growth1974，，2425： | 1 |
| 8 | A functional-hydrogenase mimic that catalyzes electron and hydride transfer from H2显示文摘 | Ogo S Ichikawa K Kishima T Matsumoto T Nakai H Kusaka K Ohhara T | 2013 | Science2013，339，6120： | 1 |
| 9 | Effective Laparoscopic Drainage for Intra-Abdominal Abscess Not Amenable to Percutaneous Approach: Report of Two Cases显示文摘 | Tomo Kimura M.D. Ph.D. Masahiko Shibata M.D. Ph.D. Moritaka Ohhara M.D. Ph.D | 2005 | Diseases of the Colon & Rectum2005，，2： | 1 |
| 10 | Study of microcirculatory changes in experimental dietary fatty liver显示文摘 | Ohhara K | 1989 | Hokkaido Igaku Zasshi1989，64，： | 1 |
| 11 | Combination of ethylbenzene dehydrogenation and carbon dioxide shift- reaction over a sodium oxide/alumina catalyst 显示文摘 | Sato S Ohhara M Sodesawa T | 1988 | Applied Catalysis1988，37，12： | 1 |
| 12 | Helicobacter pylori-Stimulated Interleukin-8 (IL-8) Promotes Cell Proliferation Through Transactivation of Epidermal Growth Factor Receptor (EGFR) by Disintegrin and Metalloproteinase (ADAM) Activation显示文摘 | Takashi Joh MD Hiromi Kataoka MD PhD Satoshi Tanida Katsushi Watanabe MD Tadayuki Ohshima MD PhD Makoto Sasaki MD Haruhisa Nakao MD Hirotaka Ohhara MD Shigeki Higashiyama PhD Makoto Itoh MD | 2005 | Digestive Diseases and Sciences2005，，11： | 1 |
| 13 | Combination of ethylbenzene dehydrogenation and carbon dioxide shift reaction over a sodium oxide/alumina catalyst 显示文摘 | Sato S Ohhara M Sodesawa T | 1988 | Appl Catal1988，37，12： | 1 |
| 14 | Chiral Dirac Fermion in a Collinear Antiferromagnet显示文摘In a Dirac semimetal, the massless Dirac fermion has zero chirality, leading to surface states connected adiabatically to a topologically trivial surface state as well as vanishing anomalous Hall effect. Recently, it is predicted that in the nonrelativistic limit of certain collinear antiferromagnets, there exists a type of chiral“Dirac-like” fermion, whose dispersion manifests four-fold degenerate crossing points formed by spin-degenerate linear bands, with topologically protected Fermi arcs. Such an unconventional chiral fermion, protected by a hidden SU(2) symmetry in the hierarchy of an enhanced crystallographic group, namely spin space group, is not experimentally verified yet. Here, by angle-resolved photoemission spectroscopy measurements, we reveal the surface origin of the electron pocket at the Fermi surface in collinear antiferromagnet CoNb3S6. Combining with neutron diffraction and first-principles calculations, we suggest a multidomain collinear antiferromagnetic configuration, rendering the the existence of the Fermi-arc surface states induced by chiral Dirac-like fermions.Our work provides spectral evidence of the chiral Dirac-like fermion caused by particular spin symmetry in CoNb_(3)S_(6), paving an avenue for exploring new emergent phenomena in antiferromagnets with unconventional quasiparticle excitations. | 张奥 邓可 盛洁明 刘鹏飞 Shiv Kumar Kenya Shimada 江志诚 刘正太 沈大伟 李嘉裕 任俊 王乐 周良 Yoshihisa Ishikawa Takashi Ohhara Qiang Zhang Garry McIntyre Dehong Yu 刘恩克 吴留锁 陈朝宇 刘奇航 | 2023 | Chinese Physics Letters2023，40，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员