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| 1 | Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB. | Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | 尿酸是正常高值血压发展为高血压的一个重要危险标志物显示文摘正常高值血压常发展为高血压,是一个与心血管病和脑卒中高死亡率和高发病率相关的事件。然而,正常高值血压发展成高血压的危险因素仍不清楚。研究者采用年龄(52.1±11.0)岁日本成年高血压患者3584例(2081例为男性)的资料进行前瞻性群体研究,研究对象在2004年被发现处于正常高值血压阶段,并在2009年重新进行检查。 | 黄洁 叶鹏 Kuwabara M Hisatome I Niwa K Hara S Roncal-Jimenez CA Bjornstad P Nakagawa T Andres-Hernando A Sato Y Jensen T Garcia G Rodriguez-Iturbe B Ohno M Lanaspa MA Johnson RJ | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 3 | Quantitative aspects of reversible osmotic opening of the blood-brain barrier显示文摘 | Rapoport S I Fredericks W R Ohno K | 1980 | Am J Physiol1980，238，5： | 2 |
| 4 | Progno stic value of CerbB-2 expression in breast cancer显示文摘 | Tsutsui S Ohno S Murakami S | 2002 | Surg Oncol2002，79，4： | 1 |
| 5 | M icrovessel quantification and its possible relation with liver me- tastasis in colorectal cancer 显示文摘 | Tomisaki S Ohno S Ichiyoshi Y et at | 1996 | Cancer1996，77，8： | 1 |
| 6 | Activation of PI3K/Akt signaling and hormone resistance in breast cancer显示文摘 | Tuoknaga E Kimura Y Mashino K Oki E Kataoka A Ohno S Morita M Kakeji Y Baba H Maehara Y | 2006 | Breast Cancer2006，13，2： | 1 |
| 7 | Crossing test among floating Ulva thalli forming ‘green tide' in Japan显示文摘 | HIRAOKA M OHNO M KAWAGUCHI S | 2004 | Hydrobiologia2004，512，1： | 1 |
| 8 | Simultaneous nitrogen and phosphorus removal using denitrifying phosphate-accumulating organisms in a sequencing batch reactor显示文摘 | Tsuneda S Ohno T Soejima K | 2006 | Biochem Eng J2006，27，3： | 1 |
| 9 | Expression and prognostic significance of PTEN product protein in patients with esophageal squamous cell carcinoma显示文摘 | TACHIBANA M SHIBAKITA M OHNO S | 2002 | Cancer2002，94，7： | 1 |
| 10 | Simulation of Airbag Impact on Post--radial Keratotomy Eye Using Finite Element Analysis显示文摘 | Uchio E Ohno S Kudoh K | 2001 | Journal of Cataract Refractive Surgery2001，27，11： | 1 |
| 11 | 显示文摘 | Kawasaki N Uemura S Ohno S | 1973 | Kobunshi Kagaku1973，30，338： | 1 |
| 12 | Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells显示文摘 | Ohno S | 2013 | Mol Ther2013，21，1： | 1 |
| 13 | Role of Cyclooxygenase-2 in Immunomodulation and Prognosis of Endometrial Carcinoma 显示文摘 | Ohno Y Ohno S Suzuki N etal | 2005 | Int J Cancer2005，114，5： | 1 |
| 14 | Microstructure and anodic polarization behavior of experimental Ag-18Cu-15Pd-12Au alloy in aqueous sulfide solution显示文摘 | Endo K Ohno H Asakura S | 2003 | J Master Sci Mater Med2003，14，5： | 1 |
| 15 | Deranged blood coagulation equilibrium as a factor of massive liver necrosis following endotoxin administration in partially hepatectomized rats 显示文摘 | MOCHIDA S ARAI M OHNO A | 1999 | Hepatology1999，29，5： | 1 |
| 16 | A simple method for calcμLating the probability of excluding paternity with any number of codominant alleles 显示文摘 | Ohno Y Sebetan IM Akaishi S | 1982 | Forensic Sci Int1982，19，1： | 1 |
| 17 | Crocin prevents the death of rat pheochromyetoma (PC - 12 ) cells by its antioxidant effects stronger than those of alpha - tocopherol显示文摘 | Oehiai T Ohno S Soeda S | 2004 | Neurosei Lett2004，362，1： | 1 |
| 18 | Effect of diamine treatment on the conversion efficiency of PbSe colloidal quantum dot solar cells显示文摘 | Kitada S Kikuchi E Ohno A | 2009 | Solid State Commun2009，149，： | 1 |
| 19 | Prognostic value of c-erbB-2 expression in breast cancer显示文摘 | Tsutsui S Ohno S Murakami S | 2002 | J Surg Oncol2002，79，4： | 1 |
| 20 | Purification and characterization of 3alpha/beta-hydroxysteroid dehydrogenase from mature porcine testicular cytosol显示文摘 | Nakajin S Fujita Y Ohno S | 1994 | J Steroid Biochem Mol Biol1994，48，23： | 1 |
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