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| 1 | Proposal of criteria to select candidates with colorectal liver metastases for hepatic resection:Comparison of our scoring system to the positive number of risk factors显示文摘AIM: To select accurately good candidates of hepatic resection for colorectal liver metastasis. METHODS: Thirteen clinicopathological features, which were recognized only before or during surgery, were selected retrospectively in 81 consecutive patients in one hospital (GroupⅠ). These features were entered into a multivariate analysis to determine independent and significant variables affecting long-term prognosis after hepatectomy. Using selected variables, we created a scoring formula to classify patients with colorectal liver metastases to select good candidates for hepatic resection. The usefulness of the new scoring system was examined in a series of 92 patients from another hospital (Group Ⅱ), comparing the number of selected variables. RESULTS: Among 81 patients of GroupⅠ, multivariate analysis, i.e. Cox regression analysis, showed that multiple tumors, the largest tumor greater than 5 cm in diameter, and resectable extrahepatic metastases were significant and independent prognostic factors for poor survival after hepatectomy (P < 0.05). In addition, these three factors: serosa invasion, local lymph node metastases of primary cancers, and post- operative disease free interval less than 1 year including synchronous hepatic metastasis, were not significant, however, they were selected by a stepwise method of Cox regression analysis (0.05 < P < 0.20). Using these six variables, we created a new scoring formula to classify patients with colorectal liver metastases. Finally, our new scoring system not only classified patients in GroupⅠvery well, but also that in Group Ⅱ, according to long-term outcomes after hepatic resection. The positive number of these six variables also classified them well.CONCLUSION: Both, our new scoring system and the positive number of significant prognostic factors are useful to classify patients with colorectal liver metastases in the preoperative selection of good candidates for hepatic resection. | Ikuo Nagashima Tadahiro Takada Miki Adachi Hirokazu Nagawa Tetsuichiro Muto Kota Okinaga | 2006 | World Journal of Gastroenterology2006，12，39： | 5 |
| 2 | Proposal of a new and simple staging system of colorectal liver metastasis显示文摘AIM: To create a new, simple and useful staging system for colorectal liver metastasis analogous to the Tumor Node Metastasis classification system of International Union Against Cancer. METHODS: A retrospective review was undertaken of 81 consecutive patients who underwent partial hepatec- tomy for colorectal liver metastases (group 1). Clinical and pathological features of both primary and metastatic liver cancers were entered into a multivariate analysis to determine independent variables helpful in accurately predicting long-term prognosis after hepatectomy. Using selected variables, we created a new staging system like TNM classification. The usefulness of the new staging system was examined in a series of 92 patients from an- other hospital (group 2). RESULTS: Multivariate analysis showed that 81 patients in group 1 had significant multiple hepatic tumors with the largest tumor being more than 5 cm in diameter, resectable extrahepatic distant metastases, and inde- pendent prognostic factors for poor survival after hepa- tectomy. Using these three variables, we created a new staging system to classify patients with colorectal liver metastases. Finally, our new staging system classified the patients both in group 1 and in group 2. CONCLUSION: Our new staging system of colorectal liver metastasis is simple and useful for staging patients. | Ikuo Nagashima Tadahiro Takada Hirokazu Nagawa Tetsuichiro Muto Kota Okinaga | 2006 | World Journal of Gastroenterology2006，12，43： | 2 |
| 3 | A scoring system for the assessment of the risk of mortality after partial hepatectomy in patients with chronic liver function显示文摘 | Nagashima I Takada T Okinaga K | 2005 | J Hepatobiliary Pancreat Surg2005，12，1： | 1 |
| 4 | Genetic polymor phism of theN, sp2 gene in North American type porcine re productive and respiratory syndrome virus显示文摘 | Yoshii M Okinaga T Miyazaki A | 2008 | Arch Virol2008，153，7： | 1 |
| 5 | Increased carbon monoxide in exhaled air of asthmatic patients显示文摘 | Zayazu K Sekizawa K Okinaga S | 1997 | Am J Respir Crit Care Med1997，156，： | 1 |
| 6 | Differentiation of femoral versus inguinal hernia:CT findings显示文摘 | Suzuki S Furui S Okinaga K | 2007 | AJR Am J Roentgenol2007，189，2： | 1 |
| 7 | Role of caspases in cleavage of lamin A/C and PARP during apoptosis in macrophages infected with a periodontopathic bacterium显示文摘 | Okinaga T Kasai H Tsujisawa T | 2007 | J Med Microbiol2007，56，10： | 1 |
| 8 | Genetic polymorphism of the nsp2 gene in North American type2porcine re- productive and respiratory syndrome virus 显示文摘 | Yoshii M Okinaga T Miyazaki A | 2008 | Arch Virol2008，153，7： | 1 |
| 9 | Linear x-y synchronous motor without force ripple and core loss for precision two-dimension drive显示文摘 | Fujii N Okinaga K | 2002 | IEEE Trans on Magnetics2002，38，5： | 1 |
| 10 | Genetic poly- morphism of the nsp2 gene in North American type- Porcine reproductive and respiratory syndrome virus 显示文摘 | Yoshii M Okinaga T Miyazaki A | 2008 | Arch Virol2008，153，7： | 1 |
| 11 | C5L2,a nonsignaling C5a binding protein显示文摘 | Okinaga S Slattery D Humbles A | 2003 | Biochemistry2003，42，31： | 1 |
| 12 | Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema显示文摘 | Yamada N Yamaya M Okinaga S | 2000 | Am J Hum Genet2000，66，： | 1 |
| 13 | Mechanisms involved in suppression of ADAMTS4 expression in synoviocytes by high molecular weight hyaluronic acid显示文摘 | Yoshihiro Kataoka Wataru Ariyoshi Toshinori Okinaga Takeshi Kaneuji Sho Mitsugi Tetsu Takahashi Tatsuji Nishihara | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 14 | Mechanisms involved in suppression of ADAMTS4 expression in synoviocytes by high molecular weight hyaluronic acid显示文摘 | Kataoka Y Ariyoshi W Okinaga T | 2013 | Biochem Biophys Res Commun2013，432，4： | 1 |
| 15 | 显示文摘 | Yamada N Yamaya M Okinaga S | 2000 | Am J Hum Genet2000，66，： | 1 |
| 16 | C5L2, a nonsignaling C5a binding protein显示文摘 | Okinaga S Slattery D Humbles A | 2003 | Biochemistry2003，42，31： | 1 |
| 17 | Microsatellitepolymorphism in the heine oxygenase-1 gene promoter is associated with suscepfibilityto emphysema显示文摘 | Norihlro Y Yamaya M Okinaga S | 2000 | Hum Cenet2000，66，： | 1 |
| 18 | Genetic polymorphism of the nsp2 gene in North American type-porcine reproductive and respiratory syndrome virus显示文摘 | Yoshii M Okinaga T Miyazaki A | 2008 | Arch Virol2008，153，7： | 1 |
| 19 | Intracellular targeting therapy of cisplatin-encapsulated transferrin-polyethylene glycol liposome on peritoneal dissemination of gastric cancer显示文摘 | Iinuma H Maruyama K Okinaga K | 2002 | Int J Cancer2002，99，1： | 1 |
| 20 | Role of estrogen receptor beta in uterine sltoma and epithelium:insights from estrogen receptor beta-/-mice显示文摘 | Wada-Hiraike O Hiraike H Okinaga H | 2006 | Proc Natl Acad Sci USA2006，103，18： | 1 |
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