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| 1 | Epithelial ovarian cancer:An overview显示文摘Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions. | Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh William Grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao | 2014 | World Journal of Translational Medicine2014，3，1： | 10 |
| 2 | Antimicrobial and antispasmodic activity of leaf extract and fractions of Stachytarpheta cayennensis显示文摘Objective:To investigate the antimicrobial activity of the methanol leaf extract(ME),n-hexane fraction(HF),ethylacetate fraction(EF) and methanol fraction(MF),of Stachytarpheta cayennensis C.Rich(verbenaceae) as well as to ascertain the antispasmodic effects of the ME and the various fractions(HF,EF and MF) on acetylcholine(Ach) and histamine(H) induced contractions on isolated guinea pig ileum.Methods:The in vitro agar well diffusion method was used for the antimicrobial studies while the isolated tissue method was employed for the antispasmodic test. Organisms used were all clinical isolates of Bacillus subtilis,Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella paratyphi,Candida albicans and Aspergillus niger.Results:The extract and fractions exhibited dose dependent inhibition against all the bacteria tested and also exhibited insignificant antifungal activity against Candida albicans and Aspergillus niger.The minimum inhibitory concentration(MIC) of the extract and fractions(mg/mL) on Bacillus subtilis, Staphylococcus aureus,Pseudomonas aeruginosa and Salmonella paratyphi respectively were ME 5.62,14.12,22.38,2.11;EF 1.25,6.30,9.40,9.40 and MF 3.98,8.81,39.80,21.13.The n-hexane fraction exhibited MIC of 1.07 mg/mL against only Bacillus subtilis.The extract and fractions exhibited significant(P< 0.05) dose dependent attenuation of contractions induced by acetylcholine and histamine on isolated guinea pig ileum.Concentrations of the extract and fractions(μg/mL) which evoked 50%inhibition of maximal response exhibited by Ach were ME 0.64,HF 0.16,EF 0.08 and MF 0.15,while that of histamine included ME 5.12,HF 0.16,EF 0.04 and MF 0.64.Preliminary phytochemical studies on the extract and fractions indicated the presence of carbohydrates,alkaloids,saponins,flavonoids,steroids and terpenoids.Conclusions: The extract and fractions of Stachytarpheta cayennensis possessed both antibacterial and antispasmodic effects confirming the claimed use in folkloric medicine for wound healing and gastrointestinal ulceration. | Okoye TC Akah PA Okoli CO Ezike AC Mbaoji FN | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，3： | 3 |
| 3 | Economic effect of a smoke-free law in a tobacco-growing community显示文摘 | Pyles M K Mullineaux D J Okoli C T C | 2007 | Tobacco control2007，16，1： | 1 |
| 4 | The Delphi method as a re- search tool an example,design considerations and appli- cations显示文摘 | Okoli C Pawlowski S D | 2004 | Inform Manag2004，42，1： | 1 |
| 5 | Chromosome numbers of Costus lu- canusianus (Costaceae) in Nigeria 显示文摘 | Edeoga HO Okoli BE | 2000 | Folia Geobotan2000，35，： | 1 |
| 6 | Environmental and multi-host infestation of the brown dog tick,Rhipicephalus sanguineus in Owerfi,South--east Nigeria a case report显示文摘 | Okolil I C Okoli C G and Oparal M | 2006 | Veterinarski Arhiv2006，76，1： | 1 |
| 7 | The Delphi method as a research tool: An example, design considerations and applications 显示文摘 | OKOLI C PAWLOWSKI SD | 2004 | Informa Manage2004，42，1： | 1 |
| 8 | An Improved Method for Examining Meiotic Chromosomes in Musa L 显示文摘 | Adeleke M T V Pillay M Okoli B E | 2002 | Hortscience2002，37，6： | 1 |
| 9 | The Delphi method as a research tool: an example, design considerations and applications 显示文摘 | Okoli C Pawlowski SD | 2004 | Inf Manage2004，42，： | 1 |
| 10 | Therapy of inflammatory bowel diseases in pregnancy and lactation显示文摘 | Cassina M Fabris L Okoli CL | 2009 | Expert Opin Drug Saf2009，8，6： | 1 |
| 11 | Use of P- glycoprotein gene probes to investigate anthelmintic resistance in Haemonchus contortus and comparison with Onchocerca vol- vulus 显示文摘 | KWA M S OKOLI M N SCHULE-KEY H et at | 1998 | Int J Parasito11998，28，8： | 1 |
| 12 | Investigating recognition-based performance in an open content community:A social capital perspective 显示文摘 | Okoli C Oh W | 2007 | Information & Management2007，44，3： | 1 |
| 13 | Application of magnetic iron oxide nanoparticles prepared fi'om microemulsions for protein purifi- cation显示文摘 | Okoli C Boutonnet M Mariey L | 2011 | Journal of Chemical Technology and Biotechnology2011，86，11： | 1 |
| 14 | Differential effects of chronic cyanide intoxication on heart, lung and pancreatic tissues 显示文摘 | Okolie NP Osagie AU | 2000 | FoodChemToxicol2000，38，6： | 1 |
| 15 | In vitro studies on antimicrobial activities of lactic acid bacteria isolated from fresh vegetables for biocontrol of tomato pathogens显示文摘 | Emerenini EC Afolabi OR Okolie PI | 2014 | British Microbiology Research Journal2014，4，3： | 1 |
| 16 | Investigating Recognition -based Performance in an Open Content Community: A Social Capital Perspective 显示文摘 | Okoli C Oh W | 2007 | Information & Management2007，44，3： | 1 |
| 17 | Processing and properties of advanced porous ceramics: An application based review显示文摘 | HAMMEL E C IGHODARO O L R OKOLI O I | 2014 | Ceramics International2014，40，15： | 1 |
| 18 | Fibrin matrices enhance the transplant and efficacy of cytotoxic stem cell therapy for post- surgicalcancer 显示文摘 | Bag6 JR Pegna GJ Okolie O | 2016 | Biomaterials2016，84，： | 1 |
| 19 | Comparison and functionalization study of microemulsion-pre-pared magnetic iron oxide nanoparticles 显示文摘 | OKOLI C SANCHEZ DOMINGUEZ M BOUTONNET M | 2012 | Langmuir2012，28，22： | 1 |
| 20 | Postintubation uvular necrosis 显示文摘 | Commins DJ Whittet H Okoli UC | 1994 | Anaesthesia1994，49，5： | 1 |
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