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| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | 结合珠蛋白2的变异促进脑卒中幸存者过早因心血管病死亡显示文摘结合珠蛋白(Haptoglobin,Hp)是一种急性期血浆蛋白,可保护组织免受氧化损伤。它存在2个变异等位基因(hp1/hp2),产生具有不同生化特性和不同功能的3种蛋白质异构体。先前研究发现, | Ij?s P Melkas S Saksi J Jula A Jauhiainen M Oksala N Pohjasvaara T Kaste M Karhunen PJ Lindsberg P Erkinjuntti T 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 3 | Expression of proteoglycans and hyaluronan during wound healing显示文摘 | Salvo T Tammi R | 1995 | J Histochem Cytochem1995，43，2： | 1 |
| 4 | Long-term survival afterisehemic stroke in postmenopausal women is affected by aninteraction between smoking and genetic variation in nitric oxidesynthases 显示文摘 | Oksala NK Oksala A Erkinjuntti T | 2008 | Cerebrovasc Dis2008，26，3： | 1 |
| 5 | Heat shock protein 60 response to exercise in diabtes: effects of alpha-lipoic acid supplementation 显示文摘 | OKsala NK Laaksonen DE Lappalainen J | 2006 | Diabetes Complications2006，20，4： | 1 |
| 6 | Alpha-lipoic acid modulates heat shock factor-l' expression in streptozotocin-induced diabetic rat kidney 显示文摘 | Oksala NK Lappalainen J Laaksonen DE | 2007 | Antioxid Redox Signal2007，9，4： | 1 |
| 7 | Alpha-lipoic acid mod- ulates heat shock factor-I expression in streptozotocin-induced diabetic rat kidney 显示文摘 | Oksala NK Lappalainen J Laaksonen DE | 2007 | Antioxid Redox Signal2007，9，4： | 1 |
| 8 | Alpha-lipoie acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney 显示文摘 | OKSALA NK LAPPALAINEN J LAAKSONEN DE | 2007 | Antioxid Redox Signal2007，9，4： | 1 |
| 9 | Factors predisposing to oral yeast infections显示文摘 | Oksala E | | 0，，： | 1 |
| 10 | Cognitive impair- ment predicts poststroke death in long-term follow-up显示文摘 | Oksala NK Jokinen H Melkas S | 2009 | J Neurol Neurosurg Psychiatry2009，80，11： | 1 |
| 11 | Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study显示文摘 | Raitoharju E Seppala I Oksala N | 2014 | Mol Cell Endocrinol2014，，： | 1 |
| 12 | Smoking and the platelet fibrinogen receptor glycoprotein Ⅱb/Ⅲa P1A1/A2 polymorphism interact in the risk of lacunar stroke and midterm survival显示文摘 | Heikkinen M Mikkelsson J | 2007 | Stroke2007，38，： | 1 |
| 13 | Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia显示文摘 | Yang R Miki K Oksala N | | 0，，02： | 1 |
| 14 | Cognitive impairment predicts poststroke death in long-term follow-up显示文摘 | Oksala NK Jokinen H Melkas S | 2009 | J Neurol Neurosurg Psychiatry2009，80，： | 1 |
| 15 | Modified ankle-brachial index detects more patients at risk in a Finnish primary health care显示文摘 | Oksala NK Viljamaa J Saimanen E | 2010 | Eur J Vasc Endovasc Surg2010，39，2： | 1 |
| 16 | Association of the novel single-nueleotide polymorphism which increases oxidized low-den- sity lipoprotein levels with cerebrovascular disease events 显示文摘 | Makeli KM Traylor M Oksala N | 2014 | Atherosclerosis2014，234，1： | 1 |
| 17 | Poststroke dementia predicts poor survival in long-term follow-up:influence of prestroke cognitive decline and previous stroke显示文摘 | Melkas S Oksala NK Jokinen H | 2009 | J Neurol Neurosurg Psychiatry2009，80，： | 1 |
| 18 | Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells显示文摘 | Ryhanen T Mannermaa E Oksala N | | 0，，： | 1 |
| 19 | Complications in antireflux surgery: national - based analysis of laparoscopic and open fundoplications 显示文摘 | RANTANEN TK OKSALA NK | 2008 | Arch Surg2008，143，4： | 1 |
| 20 | Expression of proteoglycans and hyaluronan during wound healing显示文摘 | Oksala O Salo T Tammi R | 1995 | J Histochem Cytochem1995，43，2： | 1 |
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