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| 1 | Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis显示文摘AIM: To examine the influence of lipoprotein lipase (LPL) gene polymorphism in ulcerative colitis (UC) patients. METHODS: Peripheral blood was obtained from 131 pa- tients with UC and 106 healthy controls for DNA extrac- tion. We determined LPL gene polymorphisms affecting the enzyme at Ser447stop, as well as HindⅢ and Pvu Ⅱ polymorphisms using PCR techniques. PCR products were characterized by PCR-RFLP and direct sequencing. Polymorphisms were examined for association with clini- cal features in UC patients. Genotype frequencies for LPL polymorphisms were also compared between UC patients and controls. RESULTS: In patients with onset at age 20 years or younger, C/G and G/G genotypes for Ser447stop poly- morphism were more prevalent than C/C genotype (OR = 3.13, 95% CI = 0.95-10.33). Patients with H+/- or H-/-genotype for HindⅢ polymorphism also were more nu- merous than those with H+/+ genotype (OR = 2.51, 95% CI = 0.85-7.45). In the group with H+/+ genotype for HindⅢ polymorphism, more patients had serum triglyc- eride concentrations over 150 mg/dL than patients with H+/- or H-/- genotype (P < 0.01, OR = 6.46, 95% CI = 1.39-30.12). Hypertriglycemia was also more prevalent in patients with P+/+ genotypes for PvuⅡ polymorphism (P < 0.05, OR = 3.0, 95% CI = 1.06-8.50). Genotype fre- quency for LPL polymorphism did not differ significantly between UC patients and controls. CONCLUSION: Ser447stop and HindⅢ LPL polymor- phisms may influence age of onset of UC, while HindⅢ and PvuⅡ polymorphisms influence serum triglyceride in UC patients. | Toshihito Kosaka Junji Yoshino Kazuo Inui Takao Wakabayashi Kazumu Okushima Takashi Kobayashi Hironao Miyoshi Yuta Nakamura Shigekazu Hayashi Taizou Shiraishi Masatoshi Watanabe Takayuki Yamamoto Ai Nakahara Takahiko Katoh | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 2 | Comrolled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices显示文摘 | Okushima S Nisisako T Torii T | 2004 | Langmuir2004，20，23： | 1 |
| 3 | ARF7 and ARF19 regulate lateral root formation via direct activation of LBD/ASL genes in Arabidopsis显示文摘 | OKUSHIMA Y FUKAKI H ONODA M | 2007 | The Plant Cell2007，19，1： | 1 |
| 4 | Oseltamivir and early deterioration leading to death:a proportional mortality study for 2009A/H1N1 influenza显示文摘 | Hama R Jones M Okushima H | | 0，，04： | 1 |
| 5 | Complementary DNA Cloning and Characterization of Pearlin, a New Class of Matrix Protein in the Nacreous Layer of Oyster Pearls显示文摘 | MIYASHITA T TAKAGI R OKUSHIMA M | 2000 | Mar Biotechnol2000，2，5： | 1 |
| 6 | A carbonic anhydrase from the nacreous layer in oyster pearls 显示文摘 | Miyamoto H Miyashita T Okushima M | 1996 | Proc Natl Acad Sci USA1996，93，18： | 1 |
| 7 | The Residual Stress Produced by Metal Cutting显示文摘 | Okushima K Kakino Y | 1971 | Annals of the CIRP1971，21，1： | 1 |
| 8 | Inhalational conscious sedation with nitrous oxide enhances the cardiac parasympathetic component of heart rate variability 显示文摘 | Okushima K Kohjitani A Asano Y | 2008 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2008，106，6： | 1 |
| 9 | A support system for natural ventilation design of greenhouse based on computational aerodynamics显示文摘 | Okushima L Sase S Nara M | 1989 | Acta Hortic1989，284，1： | 1 |
| 10 | Oseltamivir and early deterioration leading to death:a proportional mortality study for 2009A/H1N1 influenza显示文摘 | Hama R Jones M Okushima H | | 0，，04： | 1 |
| 11 | Func- tional genomic analysis of the AUXIN/INDOLE-3-ACE- TIC ACID gene family members in Arabidopsis thaliana 显示文摘 | Overvoorde P J Okushima Y Alonso J M | 2005 | Plant Cell2005，17，12： | 1 |
| 12 | Development of expansive cement with calcium sulphoaluminous cement clinker显示文摘 | KONDO R | 1968 | Fifth International Symposium on the Chemisitry Ofcement (Tokyo)1968，，4： | 1 |
| 13 | Functional genomic analysis of the auxirdindole-3-acetic acid gone family members in Arabidopsis thaliana显示文摘 | Overvoorde PJ Okushima Y Alonso JM | 2005 | The Plant Cell2005，17，12： | 1 |
| 14 | Oseltamivir and early deterioration leading to death:aproportional mortality study for 2009A/H1N1 influenza显示文摘 | Hama R Jones M Okushima H | | 0，，04： | 1 |
| 15 | Isolation and characterization of a putative transducer of endoplasmic reticulum stress in Oryza sativa 显示文摘 | Okushima Y Koizumi N Yamaguchi Y | 2002 | Plant and Cell Physiology2002，43，5： | 1 |
| 16 | EUS-guided onestep drainage of pancreatic pseudocysts:experience in 3 patients显示文摘 | INUI K YOSHINO J OKUSHIMA K | 2001 | Gastrointest Endosc2001，54，1： | 1 |
| 17 | Support system for natural ventilation design of greenhouses based on computational aerodynamics显示文摘 | Okushima L Sase S Nara MA | 1989 | Acta Horticulture1989，284，： | 1 |
| 18 | The role of N-terminal pro-B-type natriuretic pep- tide in the diagnosis of congestive heart failure in children 显示文摘 | Sugimoto M ' Manabe H Nakau K Furuya A Okushima K Fuji- yasu H | 2010 | Circ J2010，74，5： | 1 |
| 19 | Oseltamivir and early deterioration leading to death:a proportional mortality study for 2009A/H1N1 influenza显示文摘 | Hama R Jones M Okushima H | | 0，，04： | 1 |
| 20 | Optimization of vent configuration by evaluating greenhouse and plant canopy ventilation rates under wind induced ventilation显示文摘 | Kacira M Sase S Okushima L | 2004 | Transactions of ASAE2004，47，6： | 1 |
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