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| 1 | Overview of the phytomedicine approaches against Helicobacter pylori显示文摘Helicobacter pylori(H.pylori)successfully colonizes thehuman stomach of the majority of the human popula-tion.This infection always causes chronic gastritis,butmay evolve to serious outcomes,such as peptic ulcer,gastric carcinoma or mucosa-associated lymphoid tis-sue lymphoma.H.pylori first line therapy recommend-ed by the Maastricht-4 Consensus Report comprises theuse of two antibiotics and a proton-pomp inhibitor,butin some regions failure associated with this treatmentis already undesirable high.Indeed,treatment failure isone of the major problems associated with H.pylori in-fection and is mainly associated with bacterial antibioticresistance.In order to counteract this situation,someeffort has been allocated during the last years in theinvestigation of therapeutic alternatives beyond antibi-otics.These include vaccines,probiotics,photodynamic inactivation and phage therapy,which are briefly revis-ited in this review.A particular focus on phytomedicine,also described as herbal therapy and botanical therapy,which consists in the use of plant extracts for medicinal purposes,is specifically addressed,namely considering its history,category of performed studies,tested com-pounds,active principle and mode of action.The herbs already experienced are highly diverse and usually selected from products with a long history of employ-ment against diseases associated with H.pylori infec-tion from each country own folk medicine.The studies demonstrated that many phytomedicine products have an anti-H.pylori activity and gastroprotective action.Al-though the mechanism of action is far from being com-pletely understood,current knowledge correlates the beneficial action of herbs with inhibition of essential H.pylori enzymes,modulation of the host immune system and with attenuation of inflammation. | Filipa F Vale Monica Oleastro | 2014 | World Journal of Gastroenterology2014，20，19： | 13 |
| 2 | Helicobacter pylori infection- recent developments in diagnosis显示文摘Considering the recommended indications for Helicobacter pylori(H.pylori)eradication therapy and the broad spectrum of available diagnostic methods,a reliable diagnosis is mandatory both before and after eradication therapy.Only highly accurate tests should be used in clinical practice,and the sensitivity and specificity of an adequate test should exceed 90%.The choice of tests should take into account clinical circumstances,the likelihood ratio of positive and negative tests,the cost-effectiveness of the testing strategy and the availability of the tests.This review concerns some of the most recent developments in diagnostic methods of H.pylori infection,namely the contribution of novel endoscopic evaluation methodologies for the diagnosis of H.pylori infection,such as magnifying endoscopy techniques and chromoendoscopy.In addition,the diagnostic contribution of histology and the urea breath test was explored recently in specific clinical settings and patient groups.Recent studies recommend enhancing the number of biopsy fragments for the rapid urease test.Bacterial culture from the gastric biopsy is the gold standard technique,and is recommended for antibiotic susceptibility test.Serology is used for initial screening and the stool antigen test is particularly used when the urea breath test is not available,while molecular methods have gained attention mostly for detecting antibiotic resistance. | Ana Isabel Lopes Filipa F Vale Mónica Oleastro | 2014 | World Journal of Gastroenterology2014，20，28： | 12 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Anti- Helicobacter pylori and urease inhibitory activities of resveratrol and red wine显示文摘 | Luísa Paulo Mónica Oleastro Eugenia Gallardo Jo?o António Queiroz Fernanda Domingues | 2011 | Food Research International2011，，4： | 1 |
| 5 | Helicobacter pylori Virulence Genotypes in Portuguese Children and Adults with Gastroduodenal Pathology显示文摘 | M. Oleastro M. Gerhard A. I. Lopes P. Ramalho J. Cabral A. Sousa Guerreiro L. Monteiro | 2003 | European Journal of Clinical Microbiology & Infectious Diseases2003，，2： | 1 |
| 6 | Helicobacter py or Virulence Ge notypcs in Portuguese Children and Adults with Gastroduodenal Pathology 显示文摘 | Oleastro M Gerhard M Iopes AI | 2003 | Eur J Clin Microbiol Infect Dis2003，22，2： | 1 |
| 7 | Real- time PCR assay for rapid and accurate detection of point mutations conferring resistance to clar- ithomycin in Helicobacter pylori显示文摘 | Menard A Santos A | 2003 | J Clin Microbiol2003，41，1： | 1 |
| 8 | Clinical relevance and diversity of two homologous genes encoding glycosyltransferases in Helicobacter pylori 显示文摘 | Oleastro M Santos A Cordeiro R | 2010 | J Clin Microbiol2010，48，8： | 1 |
| 9 | Features and trends in Helicobacter pylori antibiotic resistance in Lisbon area, Portugal ( 1990-1999 ) 显示文摘 | Cabrita J Oleastro M Matos R | 2000 | J Antimicrob Chemother2000，46，6： | 1 |
| 10 | Features and Trends in Helicobacter Pylori Antibiotic Resistance in Lisbon area, Portugal(1990-1999)显示文摘 | Cagrita J Oleastro M Matos R | 2000 | Journal of Antimicrobial Chemotherapy2000，46，： | 1 |
| 11 | Diagnosis of Helicobacter pylori infection 显示文摘 | Monteiro L Oleastro M Lehours P Megraud F | 2009 | Helicobacter2009，14，1： | 1 |
| 12 | Real-time PCR assay for rapid and accurate detection of point mutations conferring resistance to clarithromycin in Helicobacter pylori显示文摘 | OLEASTRO M MENARD A SANTOSA | 2003 | J Clin Microbiol2003，41，1： | 1 |
| 13 | 显示文摘 | Oleastro M Menard A Santos A | 2003 | J Clin Microbiol2003，41，1： | 1 |
| 14 | A 475 years-old founder effect involving IL-12Rβ1 : a highly prevalent mutation confereing Mendelian Susceptibility to Mycobacterial Diseases in European descendants 显示文摘 | Yancoski J Rocco C Bernasconi A Oleastro M Bezrodnik L Vratnica C Haerynck F Rosenzweig SD | 2009 | Infect Genet Evol2009，9，4： | 1 |
| 15 | Evaluation of the clinical significance of homB,a novel candidate marker of Helicobacter pylori strains associated with peptic ulcer disease显示文摘 | Oleastro M Cordeiro R Ferrand J | 2008 | J Infect Dis2008，198，9： | 1 |
| 16 | Correlation of Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries显示文摘 | Olfat FO Zheng Q Oleastro M | 2005 | FEMS Immunol Med Misrobiol2005，44，2： | 1 |
| 17 | Real-Time PCR assay for rapid and accurate detection of point mutations conferring resistance to clarithromycin in Helicobacter pylori显示文摘 | Menard A Santos A | 2003 | J Clin Microbiol2003，41，1： | 1 |
| 18 | Antibiotic-resistant Helicobacter Pylori stains in portuguese,children显示文摘 | Lopes A I Oleastro M Palha A | 2005 | Pediatr Infect Dis J2005，24，5： | 1 |
| 19 | Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries显示文摘 | OLFAT F O ZHENG Q OLEASTRO M | 2005 | J FEMS Immun Med Misrobiol2005，44，2： | 1 |
| 20 | Antibiotic-resistant Helicobacter pylori strains in PortugueSe Children显示文摘 | Lopes AI Oleastro M Palha A | | 0，，： | 1 |
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