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| 1 | Role of microRNAs in translation regulation and cancer显示文摘MicroRNAs(miRNAs) are pervasively expressed and regulate most biological functions. They function by modulating transcriptional and translational programs and therefore they orchestrate both physiological and pathological processes, such as development, cell differentiation, proliferation, apoptosis and tumor growth. miRNAs work as small guide molecules in RNA silencing, by negatively regulating the expression of several genes both at mRNA and protein level, by degrading their mRNA target and/or by silencing translation. One of the most recent advances in the field is the comprehension of their role in oncogenesis. The number of miRNA genes is increasing and an alteration in the level of miRNAs is involved in the initiation, progression and metastases formation of several tumors. Some tumor types show a distinct miRNA signature that distinguishes them from normal tissues and from other cancer types. Genetic and biochemical evidence supports the essential role of miRNAs in tumor development. Although the abnormal expression of miRNAs in cancer cells is a widely accepted phenomenon, the cause of this dysregulation is still unknown. Here, we discuss the biogenesis of miRNAs, focusing on the mechanisms by which they regulate protein synthesis. In addition we debate on their role in cancer, highlighting their potential to become therapeutic targets. | Stefania Oliveto Marilena Mancino Nicola Manfrini Stefano Biffo | 2017 | World Journal of Biological Chemistry2017，8，1： | 60 |
| 2 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 3 | On the runtime analysis of the Simple Genetic Algorithm显示文摘 | Oliveto PS Witt C | 2014 | Theoretical Computer Science2014，，545： | 1 |
| 4 | Time domain response of a one- dimensional soil-structure interacting model via complex analysis显示文摘 | Oliveto G Santini A | 1996 | Engineering Structures1996，18，： | 1 |
| 5 | Simplified drift analysis for proving lower bounds in evolutionary computation 显示文摘 | OLIVETO P S WITI' C | 2011 | Algorithmica2011，59，3： | 1 |
| 6 | Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine versus methadone显示文摘 | Oliveto AH Feingold A Schottenfeld R | 1999 | Arch General Psychiatry1999，56，9： | 1 |
| 7 | COMPLEX MODAL ANALYSIS OF A FLEXURAL VIBRATING BEAM WITH VISCOUS END CONDITIONS显示文摘 | G. Oliveto A. Santini E. Tripodi | 1997 | Journal of Sound and Vibration1997，，3： | 1 |
| 8 | Experimental test and modeling of hollow-core composite insulators 显示文摘 | Roh H Oliveto N D Reinhorn A M | 2012 | Nonlinear Dynamics2012，69，4： | 1 |
| 9 | Treatment of heroin (diamorphine)addiction current approaches and future prospects显示文摘 | Gonzalez G Oliveto A Kosten TR | 2002 | Drugs2002，62，： | 1 |
| 10 | The preparation of HC from cortisone acetate显示文摘 | Oliveto E P Richard Russer Veber L | 1956 | J Am Chem Soc1956，78，： | 1 |
| 11 | Vibrating Beam with Viscous End Conditions显示文摘 | OLIVETO G SANTINI A TRIPODI E Complex Modal Analysis of A Flexural | 1997 | Journal of Sound and Vi- bration1997，200，3： | 1 |
| 12 | A systematic survey of caffeine intake in Vermont显示文摘 | HUGHES JR OLIVETO AH | 1997 | Exp Clin Psychopharmacol1997，5，4： | 1 |
| 13 | Endorsement of DSM-IV dependence criteria among caffeine users显示文摘 | HUGHES JR OLIVETO AH LIGUORI A | 1998 | Drug Alcohol Dependence1998，52，2： | 1 |
| 14 | Experimental test and modeling of hollow-core composite insulators 显示文摘 | Hwasung Roh Nicholas D Oliveto Andrei M Reinhorn | 2012 | Nonlinear Dyn2012，69，4： | 1 |
| 15 | Selective reduction and hydrogenation of unsaturated steroids 显示文摘 | Hershberg EB Oliveto EP Gerold C | 1951 | J American Chemical Society1951，73，： | 1 |
| 16 | Recovering test-tocode traceability using slicing and textual analysis 显示文摘 | QUSEF A BAVOTA G OLIVETO R | 2014 | Journal of Systems and Software2014，88，2： | 1 |
| 17 | Time domain response of a one-dimensional soil-structure interacting model via complex analysis显示文摘 | Oliveto G Santini A | 1996 | Engineering Structures1996，18，： | 1 |
| 18 | Large displacement behaviour of a structural model with foundation uplift under impulsive and earthquake excitations显示文摘 | Oliveto G Calio I Greco A | 2003 | Earthquake Engineering and Structural Dynamics2003，32，： | 1 |
| 19 | The collapse strength of tubular steel scaffold assemblies 显示文摘 | LIGHTFOOT E OLIVETO G | 1977 | Proceedings of the Institution of Civil Engineers Partl-Design & Construction1977，63，2： | 1 |
| 20 | Reexamining the determination of the fractal dimension of river networks显示文摘 | Claps P Oliveto G | 1996 | Water Resources Research1996，32，10： | 1 |
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