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| 1 | Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research显示文摘Purpose:To review the clinical and research value of optical coherence tomography angiography(OCTA)in the field of neurology.Methods:Current literature involving OCTA were reviewed through PubMed using the search terms“optical coherence tomography angiography”,with“multiple sclerosis”,“Alzheimer’s disease”,“optic neuropathy”,or other closely-related terms.Results:OCTA has been applied in research to advance our understanding of the pathobiology of neurological disorders.OCTA-derived blood flow and vessel density measures are altered in multiple sclerosis(MS),Alzheimer’s disease(AD),and various optic neuropathies(ON)in varying regions of the posterior segment vasculature of the eye.These emerging research findings support the occurrence of retinal vascular alterations across a host of neurological disorders and raise the possibility that vasculopathy can be clinically relevant since it contributes to the pathobiology of several neurological disorders.Conclusion:OCTA may be beneficial for neurological research.Additional investigations using OCTA in neurological disorders will help to further validate its clinical and research utilities in terms of characterizing the role of vasculopathy in neurological disorders. | Liang Wang Olwen Murphy Natalia Gonzalez Caldito Peter A.Calabresi Shiv Saidha | 2018 | Eye and Vision2018，5，1： | 6 |
| 2 | Sorafenib显示文摘 | Olwen Hahn Walter Stadler | 2006 | Current Opinion in Oncology2006，，6： | 1 |
| 3 | Testosterone, aggression, physical and personality dimensions in normal adoles- cent males 显示文摘 | Olwens D Mattson A SchaUing D | 1980 | psychosomatic Medicine1980，42，： | 1 |
| 4 | The Employment of People with Criminal Records in the Eu- ropean Union 显示文摘 | Nancy Louks Olwen Lyner and Tom Sullivn | 1998 | European Journal on Criminal Policy and Research1998，，6： | 1 |
| 5 | Environmental policy integration and the architecture of global environmental governance 显示文摘 | Frank Biermann Olwen Davies Nicolien van der Grijp | 2009 | Int Environ Agreements2009，，9： | 1 |
| 6 | Testosterone, aggression, physical and personality dimensions in normal adolescent males显示文摘 | Olwens D | 1980 | Psychosom atic Med1980，42，： | 1 |
| 7 | The'common stem cell'hypothesis reevaluated:human fetal bone marrow contains separate populations of hematopoiefic and stromal progenitors显示文摘 | Waller EK Olwens J Lund-Johansen F | 1995 | Blood1995，85，： | 1 |
| 8 | Testosterone,aggression,physical and personalitydimensions in normal adolescent males显示文摘 | Olwens D | | 0，，： | 1 |
| 9 | Filial belief and parent-child conflict显示文摘 | Kuang-Hui Yeh Olwen Bedford | 2004 | International Journal of Psychology2004，，2： | 1 |
| 10 | A technique for studing microtine food habits显示文摘 | Olwen W | 1962 | JMammal1962，43，3： | 1 |
| 11 | Women without Men: Widows and Spin- stets in Britain and France in the Eighteen Century显示文摘 | OLWEN HUFTON | 1984 | Journal of Family History1984，9，4： | 1 |
| 12 | Towards an uncertain politics of professionalism: Teacher and nurse identities in flux显示文摘 | Ian S Brian C Olwen M N | 2002 | J Educ Policy2002，17，1： | 1 |
| 13 | Investigation of the retinol-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs显示文摘 | Max F. Rothschild Lori Messer Andy Day Richard Wales Tom Short Olwen Southwood Graham Plastow | 2000 | Mammalian Genome2000，，1： | 1 |
| 14 | A critical history of research assessment in the United Kingdom and its post- 1992 impact on education显示文摘 | Peter Gilroy Olwen McNamara | 1992 | Journal of Education for Teaching: International research and pedagogy1992，35，4： | 1 |
| 15 | A critical history of research assessment in the United Kingdom and its post-1992 impact on education显示文摘 | Peter Gilroy & Olwen McNamara | 2009 | Journal of Education for Teaching: International research and pedagogy2009，35，4： | 1 |
| 16 | A critical history of research assessment in the United Kingdom and its post-1992 impact on education显示文摘 | Peter Gilroy Olwen McNamara | 2009 | Journal of Education for Teaching: International research and pedagogy2009，35，4： | 1 |
| 17 | Microvascular blood flow velocities measured with a retinal function imager: inter-eye correlations in healthy controls and an exploration in multiple sclerosis显示文摘Background:The retinal microcirculation has been studied in various diseases including multiple sclerosis(MS).However,inter-eye correlations and potential differences of the retinal blood flow velocity(BFV)remain largely unstudied but may be important in guiding eye selection as well as the design and interpretation of studies assessing or utilizing retinal BFV.The primary aim of this study was to determine inter-eye correlations in BFVs in healthy controls(HCs).Since prior studies raise the possibility of reduced BFV in MS eyes,a secondary aim was to compare retinal BFVs between MS eyes,grouped based on optic neuritis(ON)history and HC eyes.Methods:Macular arteriole and venule BFVs were determined using a retinal function imager(RFI)in both eyes of 20 HCs.One eye from a total of 38 MS patients comprising 13 eyes with ON(MSON)and 25 eyes without ON(MSNON)history were similarly imaged with RFI.Results:OD(right)and OS(left)BFVs were not significantly different in arterioles(OD:3.95±0.59 mm/s;OS:4.08±0.60 mm/s,P=0.10)or venules(OD:3.11±0.46 mm/s;OS:3.23±0.52 mm/s,P=0.06)in HCs.Very strong inter-eye correlations were also found between arteriolar(r=0.84,P<0.001)and venular(r=0.87,P<0.001)BFVs in HCs.Arteriolar(3.48±0.88 mm/s)and venular(2.75±0.53 mm/s)BFVs in MSNON eyes were significantly lower than in HC eyes(P=0.009 and P=0.005,respectively).Similarly,arteriolar(3.59±0.69 mm/s)and venular(2.80±0.45 mm/s)BFVs in MSON eyes were also significantly lower than in HC eyes(P=0.046 and P=0.048,respectively).Arteriolar and venular BFVs in MSON and MSNON eyes did not differ from each other(P=0.42 and P=0.48,respectively).Conclusions:Inter-eye arteriolar and venular BFVs do not differ significantly in HCs and are strongly correlated.Our findings support prior observations that arteriolar and venular BFVs may be reduced in MS eyes.Moreover,this seems to be the case in both MS eyes with and without a history of ON,raising the possibility of global blood flow alterations in MS.Future larger studies are needed to assess differences in BFVs between MSON and MSNON eyes. | Liang Wang Ohemaa Kwakyi James Nguyen Esther Ogbuokiri Olwen Murphy Natalia Gonzalez Caldito Laura Balcer Elliot Frohman Teresa Frohman Peter A.Calabresi Shiv Saidha | 2018 | Eye and Vision2018，5，1： | 0 |
| 18 | Trans-synaptic degeneration as a mechanism of neurodegeneration in multiple sclerosis显示文摘Multiple sclerosis(MS) is regarded as an immunemediated,demyelinating disorder of the central nervous system,however neuroaxonal degeneration is accepted as the principal substrate of disability accumulation(Dutta and Trapp,2011). | Olwen C.Murphy Peter A.Calabresi Shiv Saidha | 2023 | Neural Regeneration Research2023，18，12： | 0 |
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