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| 1 | Impairment of ghrelin synthesis in Helicobacter pyloricolonized stomach:New clues for the pathogenesis of H.pylori-related gastric inflammation显示文摘Ghrelin,the ligand of growth hormone secretagogue receptor 1a,takes part in several functions of the digestive system,including regulation of appetite,energy homeostasis,gastric acid secretion and motility.Ghrelin has also immunoregulatory properties and is supposed to inhibit some inflammatory pathways that can mediate gastric damage.Interestingly,ghrelin synthesis is reduced in the gastric mucosa of patients with Helicobacter pylori(H.pylori)infection,a worldwide condition inducing a T helper(Th)1/Th17 cell responsedriven gastritis,which may evolve towards gastric atrophy and cancer.In this article,we review the available data on the expression of ghrelin in H.pylori infection and discuss how the defective ghrelin synthesis may contribute to sustain the ongoing inflammatory response in this disease. | Omero Alessandro Paoluzi Giovanna Del Vecchio Blanco Roberta Caruso Ivan Monteleone Giovanni Monteleone Francesco Pallone | 2014 | World Journal of Gastroenterology2014，20，3： | 8 |
| 2 | Low efficacy of levofloxacin-doxycycline-based third-line triple therapy for Helicobacter pylori eradication in Italy显示文摘AIM:To evaluate a levofloxacin-doxycycline-based triple therapy with or without a susceptibility culture test in non-responders to Helicobacter pylori(H.pylori) eradication.METHODS:A total of 142(99 women,43 men; mean 53.0 ± 12.7 years) non-responders to more than two H.pylori eradication therapies underwent susceptibility culture tests or were treated with a seven-day triple therapy consisting of esomeprazole,20 mg b.i.d.,levofloxacin,500 mg b.i.d.,and doxycycline,100 mg b.i.d.,randomly associated with(n = 71) or without(n = 71) Lactobacillus casei DG.H.pylori status was checked in all patients at enrollment and at least 8 wk after the end of therapy.Compliance and tolerability of regimens were also assessed.RESULTS:H.pylori eradication was achieved in < 50% of patients [per prototol(PP) = 49%; intention to treat(ITT) = 46%].Eradication rate was higher in patients administered probiotics than in those without(PP = 55% vs 43%; ITT = 54% vs 40%).Estimated primary resistance to levofloxacin was 18% and multiple resistance was 31%.Therapy was well tolerated,and side effects were generally mild,with only one patient experiencing severe effects.CONCLUSION:Third-line levofloxacin-doxycycline triple therapy had a low H.pylori eradication efficacy,though the success and tolerability of this treatment may be enhanced with probiotics. | Omero Alessandro Paoluzi Giovanna Del Vecchio Blanco Emanuela Visconti Manuela Coppola Carla Fontana Marco Favaro Francesco Pallone | 2015 | World Journal of Gastroenterology2015，21，21： | 5 |
| 3 | Familial colorectal cancer screening: When and what to do?显示文摘Colorectal cancer(CRC) is the third leading cause of death worldwide and represents a clinical challenge.Family members of patients affected by CRC have an increased risk of CRC development.In these individuals,screening is strongly recommended and should be started earlier than in the population with average risk,in order to detect neoplastic precursors,such as adenoma,advanced adenoma,and nonpolypoid adenomatous lesions of the colon.Fecal occult blood test(FOBT) is a non invasive,widespread screening method that can reduce CRC-related mortality.Sigmoidoscopy,alone or in addition to FOBT,represents another screening strategy that reduces CRC mortality.Colonoscopy is the best choice for screening highrisk populations,as it allows simultaneous detection and removal of preneoplastic lesions.The choice of test depends on local health policy and varies among countries. | Giovanna Del Vecchio Blanco Omero Alessandro Paoluzi Pierpaolo Sileri Piero Rossi Giuseppe Sica Francesco Pallone | 2015 | World Journal of Gastroenterology2015，21，26： | 3 |
| 4 | Chronic pelvic pain,psychiatric disorders and early emotional traumas:Results of a cross sectional case-control study显示文摘AIM To compare the prevalence of psychiatric disorders and early emotional traumas between women with chronic pelvic pain(CPP) and healthy women.METHODS One hundred women in reproductive age,50 of them had CPP(according to the criteria set by the International Association for Study of Pain),and 50 were considered healthy after the gynecological evaluation.The eligibility criteria were defined as follows:chronic or persistent pain perceived in the pelvis-related structures(digestive,urinary,genital,myofascial or neurological systems).Only women in reproductive age with acyclic pain for 6 mo,or more,were included in the present study.Menopause was the exclusion criterion.The participants were grouped according to age,school level and socioeconomic status and were individually assessed through DSM-IV Structured Clinical Interview(SCID-I) and Early Trauma Inventory Self-report-short form(ETISR-SF Brazilian version).Descriptive statistics,group comparison tests and multivariate logistics regression were used in the data analysis.RESULTS The early emotional traumas are highly prevalent,but their prevalence did not differ between the two groups.The current Major Depressive Disorder was more prevalent in women with CPP.The CPP was associatedwith endometriosis in 48% of the women.There was no difference in the prevalence of disorders when endometriosis was taken into account(endometriosis vs other diseases:P > 0.29).The current Major Depressive Disorder and the Bipolar Disorder had greater occurrence likelihood in the group of women with CPP(ODDS = 5.25 and 9.0).CONCLUSION The data reinforce the link between mood disorders and CPP.The preview evidences about the association between CPP and early traumas tended not to be significant after a stronger methodological control was implemented. | Flávia L Osório Ana Carolina F Carvalho Mariana F Donadon André L Moreno Omero Polli-Neto | 2016 | World Journal of Psychiatry2016，6，3： | 2 |
| 5 | Tips and tricks for the diagnosis and management of biliary stenosis-state of the art review显示文摘Biliary stenosis may represent a diagnostic and therapeutic challenge resulting in a delay in diagnosis and initiation of therapy due to the frequent difficulty in distinguishing a benign from a malignant stricture.In such cases,the diagnostic flowchart includes the sequential execution of imaging techniques,such as magnetic resonance,magnetic resonance cholangiopancreatography,and endoscopic ultrasound,while endoscopic retrograde cholangiopancreatography is performed to collect tissue for histopathological/cytological diagnosis or to treat the stenosis by insertion of stent.The execution of percutaneous transhepatic drainage with subsequent biopsy has been shown to increase the possibility of tissue diagnosis after failure of the above techniques.Although the diagnostic yield of histopathology and imaging has increased with improvements in endoscopic ultrasound and peroral cholangioscopy,differential diagnosis between malignant and benign stenosis may not be easy in some patients,and strictures are classified as indeterminate.In these cases,a multidisciplinary workup including biochemical marker assays and advanced technologies available may speed up a diagnosis of malignancy or avoid unnecessary surgery in the event of a benign stricture.Here,we review recent advancements in the diagnosis and management of biliary strictures and describe tips and tricks to increase diagnostic yields in clinical routine. | Giovanna Del Vecchio Blanco Michelangela Mossa Edoardo Troncone Renato Argirò Andrea Anderloni Alessandro Repici Omero Alessandro Paoluzi Giovanni Monteleone | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，10： | 1 |
| 6 | Test of stability as an aid to decide the need for osteotomy in association with open reduction in developmental dysplasia of the hip显示文摘 | Omerolu H | 2000 | Bone Joint Surg Br2000，82，6： | 1 |
| 7 | H elicobacter pylori Infection Associates with a Mucosal Downregulation of Ghrelin, Negative Regulator of Th1‐Cell Responses显示文摘 | Omero Alessandro Paoluzi Giovanna Del Vecchio Blanco Roberta Caruso Ivan Monteleone Flavio Caprioli Manfredi Tesauro Mario Turriziani Giovanni Monteleone Francesco Pallone | 2013 | Helicobacter2013，，6： | 1 |
| 8 | Renal vascular injuries显示文摘 | Tillou A R omero J Asensio JA | 2001 | Surg Clin North Am2001，81，： | 1 |
| 9 | Trichoderma atroviride G-protein a-subunit gene Tgal is invol,ed in mycoparasitic coiling and conidiation显示文摘 | Rocha-Ramirez V Omero C Chet I | 2002 | Eukaryotic Cell2002，1，： | 1 |
| 10 | Electroluminescence from Carbazole Dimers显示文摘 | omero D Nuesch F Benazzi T Ades D Siove A Zuppiroli L | | 0，，： | 1 |
| 11 | Use of ultrasonography in developmental dysplasia of the hip显示文摘 | Omero(g)lu H | 2014 | J Child Orthop2014，8，2： | 1 |
| 12 | Trichoderma atroviride G-Protein a-Subunit Gene tga1 is involved in Mycoparasitic coiling and conidiation显示文摘 | Rocha-Ramírez V Omero C Chet I | | 0，，： | 1 |
| 13 | Pediatric femur neck fractures:a retrospctive analysis of 39 hips显示文摘 | Inan U K(o)se N Omero(g)ulu H | | 0，，04： | 1 |
| 14 | High-dose vitamin C supplementation accelerates the Achilles tendon healing in healthy rats显示文摘 | Omero(ˇoverg)lu S Peker T Türk?zkan N | 2009 | Arch Orthop Trauma Surg2009，129，2： | 1 |
| 15 | Ultrasonographic Graf type IIa hip needs more consideration in newborn girls显示文摘 | Omerolu H Caylak R Inan U | 2013 | J Child Orthop2013，7，2： | 1 |
| 16 | Ttichoderma atrovilqde G-Proteinct-Subunit Gene tgal Is Involved in Mycoparasitic Coiling and Conidiation显示文摘 | Victor Rocha:Ramirez Carmi Omero Ilan Chet | 2002 | Eukaryotic Ce112002，，8： | 1 |
| 17 | Bone anatomy and rotational alignment in total knee arthroplasty显示文摘 | Ozcelik A Seber S Omeroˇglu H | 2004 | Clin Orthop Relat Res2004，，422： | 1 |
| 18 | Multimodality and Listening Comprehension: Testing and Implementing Class- room Material 显示文摘 | Domnguez R Omero E & Maiz Arrvalo C | 2010 | Language Value2010，，1： | 1 |
| 19 | Our three-year experience with an ultrasonographic hip screening program conducted in infants at 3to 4weeks of age显示文摘 | Kose N Omeroˇglu H Ozyurt B | 2006 | Acta Orthop Traumatol Turc2006，40，4： | 1 |
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