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| 1 | Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study显示文摘BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver cirrhosis.METHODS This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in Egypt.Patients were recruited from May 1,2020,to July 31,2020.Demographic,laboratory,imaging features,and outcomes were collected.Multivariate regression analysis was performed to detect factors affecting mortality.RESULTS This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)died.Fever,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver cirrhosis.Cough,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic patients.There was no difference between patients with and without cirrhosis regarding comorbidities.Fifteen patients(23.40%)with liver cirrhosis presented with hepatic encephalopathy.Patients with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compared to those with no cirrhosis:33(51.56%)vs 9(14.75%),respectively(P value<0.001).All patients in Child-Pugh class A recovered and were discharged.Cirrhotic mortality occurred among decompensated patients only.A multivariate regression analysis revealed the following independent factors affecting mortality:Male gender(OR 7.17,95%CI:2.19–23.51;P value=0.001),diabetes mellitus(OR 4.03,95%CI:1.49–10.91;P value=0.006),and liver cirrhosis(OR 1.103,95%CI:1.037–1.282;P value<0.0001).We found no differences in liver function,COVID-19 disease severity,or outcomes between patients who previously received direct-acting antiviral therapy(and achieved sustained virological response)and patients who did not receive this therapy.CONCLUSION Patients with liver cirrhosis are susceptible to higher severity and mortality if infected with COVID-19.Male gender,diabetes mellitus,and liver cirrhosis are independent factors associated with increased mortality risk. | Shimaa Afify Basem Eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 2 | 指南溃疡性结肠炎的管理:NICE指南更新汇总显示文摘溃疡性结肠炎是一种以直肠和结肠黏膜炎症为特征的慢性炎症性疾病,可导致腹泻(软便伴排次增加)、便血、便急迫和腹痛症状。炎症通常累及直肠及直肠近端不同范围的结肠。直肠的炎症称为直肠炎,直肠和乙状结肠的炎症称为直乙结肠炎。左半结肠炎是指疾病累及脾曲以远的结肠。广泛结肠炎是指疾病范围达到脾曲近端的结肠,甚至全结肠累及时的全结肠炎。 | Omnia Abdulrazcg Bernadette Li Jenny Epstein 舒慧君(译) | 2020 | 英国医学杂志中文版2020，23，7： | 2 |
| 3 | Relations of regulatory T cells with hepatitis markers in chronic hepatitis B virus infection显示文摘 | Omnia El-Badawy Douaa Sayed Mohamed S. Badary Mohamed E. Abd-Alrahman Mohamed A. El-Feky Amany G. Thabit | 2012 | Human Immunology2012，，4： | 1 |
| 4 | Bacterial nosocomial infections in neo- natal intensive care unit, Zagazig University Hospital, Egypt 显示文摘 | Doaa M Omnia S E1 S | 2014 | Egyptian Pediatric Association Gazette2014，6，2： | 1 |
| 5 | Velocity distribution inside and above branched flexible roughness显示文摘 | OMNIA EI HAKIM MOHAMED M SALAMA | 1992 | Journal of Irrigation and Drainage Engineering1992，118，6： | 1 |
| 6 | Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and AP- CI LC/MS/MS for chlorpheniramine in humanplasma and the importance of multiple source ma trix effect evaluations显示文摘 | OMNIA I A MATTHEW H S MAGDA E Y | 2008 | J Chromatogr B2008，875，2： | 1 |
| 7 | Role of multidetector computed tomography(MDCT)angiography in preoperative assessment of coarctation of the aorta in pediatric patients and young adults显示文摘 | Omnia AK Ahmed MM | 2011 | The Egyptian Journal of Radiology and Nuclear Medicine2011，42，34： | 1 |
| 8 | Experimental and numerical model for space steel and composite semi-rigid joints 显示文摘 | MOHAMED A DABAON MAHMOUND H EL- BOGHDADI OMNIA F KHAROOB | 2009 | Journal of Constructional Steel Research2009，65，89： | 1 |
| 9 | Toxicological studies for some agricultural waste extracts on mosquito larvae and experimental animals显示文摘Objective:To evaluate some agricultural waste extracts as insecticide and their effects on enzyme activities in liver and kidney of male mice.Methods:The insecticidal activity of five tested compounds(one crude extract and 4 waste compounds) was bioassay against the 3rd instars of the Culex pipiens(Cx.pipiens) larvae in the laboratory.The LC_(50) values of eucalyptol,apricot kernel.Rice bran,corn,black liquor and white liquor are 91.45.1166.1,1203.3.21449.65.4025.78 and 6343.18 ppm,respectively.Selection of the compounds for the subsequent studies was not only dependent on LC_(50) values but also on the persistence of these wastes products on large scale.Results:White and black liquor did not produce any gross effect at 200 mg/Kg body weight.No apparent toxic symptoms were observed in tested animals during the whole period of the experimenl which run out for 14 days.No statistically significance was observed in the enzyme choliuesterase activity,the activities of liver enzymes and kidney function in treated mice with black and while liquors.While,no and slighl inhibition was observed after the 2weeks ol treatment period with deltamethrin and lenilrothion reached to about 24%in plasma cholinesterase enzyme activity.Significantly increase in the activities ol liver enzymes and kidney function in treated mice with deltamethrin and fenitrothion.Conclusions:Black liquor can be used efficiently In control Cx.pipiens larvae under laboratory condition.Environmental problem caused by rice straw can be solved by converting the waste material to beneficial natural selective insecticide. | Somia El-Maghraby Galal A Nawwar Reda FA Bakr Nadia Helmy Omnia MHM Kamel | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，7： | 1 |
| 10 | Histological,Ultrastructural,and Genetic Investigatory Comparison between Different Types of Experimentally-Induced Antemortem Burns显示文摘Background:Burn is a cutaneous injury that is caused by heat,electricity,chemicals,freezing,and radiation.Aims and Objectives:This study aimed to differentiate between dry heat burn injury and other common cutaneous burn injuries.Materials and Methods:For this,different types of dermal burns were created experimentally in four groups of rats,5 rats for each,as the following:dry heat burn model,scalding model,chemical burn model,and electrical burn model.The burnt skin and hair samples were subjected to scanning electron microscopic examination,molecular assay of aquaporin-3(AQP-3)gene expression,and histopathological investigation.Results:There were crakes,holes,and cuticular irregularity in hairs exposed to both dry heat and sulfuric acid(chemical burn),while the major lesion observed in hairs exposed to boiling water(scald injury)was cuticular cell loss.On the other hand,dry burnt skin showed empty orifices of the hair and sebaceous gland with overlapped smooth lamella,while scald induced irregularity of collagen fibers.The sulfuric acid produces separation of the epidermis from the dermis and irregularity in collagen fiber.Rat skin exposed to electric current appears with fissure,lacerated edges,and erected broken hairs.Despite AQP-3 gene expression was significantly upregulated in the burnt skin of all experimental models in comparing with control rats,dry heat burned skin showed the highest upregulated level.In addition,the coagulation of the dermoepidermal cells and vesicles formation were the most pronounced lesions observed in all types of burns,while scald was distinguished by appearance of elongated cellular nuclei.Conclusion:These observations suggest the possibility to differentiate between dry thermal burn,scald injury,chemical burn,and electrical burn using the combination between scanning electron microscopic examination,analysis of cutaneous AQP-3 gene expression,and histological investigation. | Omnia I El Euony Youstina W Wisely Ashraf M Nazem Osama S El Okle | 2023 | Journal of Forensic Science and Medicine2023，9，1： | 0 |
| 11 | Evaluation of hybrid closed-loop insulin delivery system in type 1 diabetes in real-world clinical practice:One-year observational study显示文摘BACKGROUND In 2016,the Food and Drug Administration approved the first hybrid closed-loop(HCL)insulin delivery system for adults with type 1 diabetes(T1D).There is limited information on the impact of using HCL systems on patient-reported outcomes(PROs)in patients with T1D in real-world clinical practice.In this independent study,we evaluated glycemic parameters and PROs over one year of continuous use of Medtronic’s 670G HCL in real-world clinical practice.AIM To assess the effects of hybrid closed loop system on glycemic control and quality of life in adults with T1D.METHODS We evaluated 71 patients with T1D(mean age:45.5±12.1 years;59%females;body weight:83.8±18.7 kg,body mass index:28.7±5.6 kg/m2,A1C:7.6%±0.8%)who were treated with HCL at Joslin Clinic from 2017 to 2019.We measured A1C and percent of glucose time-in-range(%TIR)at baseline and 12 months.We measured percent time in auto mode(%TiAM)for the last two weeks preceding the final visit and assessed PROs through several validated quality-of-life surveys related to general health and diabetes management.RESULTS At 12 mo,A1C decreased by 0.3%±0.1%(P=0.001)and%TIR increased by 8.1%±2.5%(P=0.002).The average%TiAM was only 64.3%±32.8%and was not associated with A1C,%TIR or PROs.PROs,provided at baseline and at the end of the study,showed that the physical functioning submodule of 36Item Short-Form Health Survey increased significantly by 22.9%(P<0.001).Hypoglycemia fear survey/worry scale decreased significantly by 24.9%(P<0.000);Problem Areas In Diabetes reduced significantly by-17.2%(P=0.002).The emotional burden submodules of dietary diversity score reduced significantly by-44.7%(P=0.001).Furthermore,analysis of Clarke questionnaire showed no increase in awareness of hypoglycemic episodes.WHO-5 showed no improvements in subject’s wellbeing among participants after starting the 670G HCL system.Finally,analysis of Pittsburgh Sleep Quality Index showed no difference in sleep quality,sleep latency,or duration of sleep from baseline to 12 mo.CONCLUSION The use of HCL in real-world clinical practice for one year was associated with significant improvements in A1C,%TIR,physical functioning,hypoglycemia fear,emotional distress,and emotional burden related to diabetes management.However,these changes were not associated with time in auto mode. | Ahmed Eldib Shilton Dhaver Karim Kibaa Astrid Atakov-Castillo Tareq Salah Marwa Al-Badri Abdelrahman Khater Ryan McCarragher Omnia Elenani Elena Toschi Osama Hamdy | 2024 | World Journal of Diabetes2024，15，3： | 0 |
| 12 | Synergetic effect of Egyptian propolis in immunization of BALB/c mice against bovine cysticercosis显示文摘Objective: To evaluate the synergetic effect of an ethanolic extract of Egyptian propolis in immunization of BALB/c mice with Taenia saginata(T. saginata) crude antigen against bovine cysticercosis, with reference to its effects on liver and kidney functions.Methods: Sixty female mice BALB/c strain weighing 20 to 25 g and 6-8 weeks old were randomly allocated into six groups of ten mice each. Mice in groups 1 and 2(G1 and G2) were immunized intraperitoneally with 100 μg of T. saginata crude antigen in 100 μL phosphate buffer saline emulsified in Freund's adjuvant. Besides, the mice in G2 were administered with propolis extract simultaneously with immunization. Control mice were either administered with propolis extract(G3) or injected with the same volume of phosphate buffer saline emulsified in Freund's adjuvant(G4). The mice in G5 were non-immunized infected control while, those in G6 were non-immunized non-infected control. Two weeks after the last immunization, each mouse was challenged intraperitoneally with 5 000 oncospheres except those of G6. Ethanolic extract of propolis was prepared at a dose 50 mg/kg body weight.Results: After 24 weeks of challenge, the mice in G2 showed the highest level of protection(100%), with no cyst being detected rather than mice in G1(33.3% protection). Additionally,the ELISA results, in this study, showed higher antibody titer in G2 with reduction the alteration in liver and kidney functions compared to G1.Conclusions: Egyptian propolis could increase the level of protection against experimental challenge infection with T. saginata eggs when administered simultaneously with immunization. Furthermore, it could enhance the production of antibodies to immunized antigen and decrease the alteration in liver and kidney functions. | Omnia Mohamed Kandil Somia Ayesh Nassar Soad Mohamed Nasr Hatem Abdel Mawgoud Shalaby Seham Hendawy Faragalla Mohamed El Moghazy | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，4： | 0 |
| 13 | Modification of Serum Galectin-3 and Reversal of Cardiac Remodeling Following Pediatric Transcatheter Atrial Septal Defect Closure显示文摘Objectives:We aimed to evaluate the effect of percutaneous atrial septal defect(ASD)closure in children using right heart indices and serum galectin-3(Gal-3),as potential biomarkers of right heart remodeling.Methods:This case–control prospective study included 40 children with ASD and 25 control subjects.An echocardiographic evaluation was performed before the procedure,as well as 24 h,1 month,and 6 months after intervention.Serum Gal-3 was measured before,and 1 month after the procedure.Results:Serum Gal-3 concentration,right atrial(RA)dimensions,right ventricular(RV)dimensions,indexed RA area,and right index of myocardial performance(RIMP)were significantly increased in children with ASD compared with control subjects while tricuspid annular plane systolic excursion(TAPSE)was significantly decreased.Six months after closure,RA,and RV dimensions significantly decreased and RVfunction improved(RIMP decreased and TAPSE increased).Gal-3 oncentration significantly decreased 1 month after ASD closure,but it did not reach normal range compared with control subjects.A positive correlation between Gal-3 and age at closure,RA area,RV dimensions,and RIMP was observed.A positive correlation was observed between the decrease in Gal-3 concentration and the decrease in RA area and RV dimensions 1 month after ASD closure.A significant negative correlation was observed between TAPSE and Gal-3 concentration before and after intervention.Conclusions:Percutaneous ASD closure can improve right-sided indices and decrease serum Gal-3 concentration.Gal-3 can be used as a sensitive biomarker of right heart remodeling,with a decrease in Gal-3 concentration suggesting reversal of maladaptive remodeling. | Omnia Shafei Alyaa A.Kotby Mona MEl Ganzoury Nevin M.Habeeb Eman Elsayed | 2022 | Congenital Heart Disease2022，17，2： | 0 |
| 14 | Assessing Emotional Intelligence Competencies in Public Sector Petroleum Companies in Egypt显示文摘 | Hazem Halim Karim Salem Omnia Hassan | 2015 | Journal of US-China Public Administration2015，12，4： | 0 |
| 15 | 媚情香氛 ——2006年情人节香氛盛宴显示文摘不妨寻找一些香氛 的“新鲜”灵感,然后选择一个最佳的场景和最佳的伟情香氛来渡过你们浪漫的2006年情人节! | 沉香屑 Omnia Crystalline | 2006 | 中国化妆品(时尚版)2006，，2： | 0 |
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