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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Changes in the etiology, incidence and prognosis of acute lower respiratory track infections in human immunodeficiency virus patients显示文摘 | Rafael Perelló Ona Escoda Silvia Camón òscar Miró Marta Casta?eda Asunción Moreno Maria ángeles Marcos Verónica Perea Natalia Alcolea Miquel Sánchez Josep Maria Gatell Esteban Martínez | 2014 | Enfermedades Infecciosas y Microbiologia Clinica2014，，： | 1 |
| 3 | The Capsid Protein of Infectious Bursal Disease Virus Contains a Functional α4β1 Integrin Ligand Motif显示文摘 | L Delgui Ona A Gutierrez S | 2009 | Virology2009，386，2： | 1 |
| 4 | Binding of the general an- esthetics chloroform and 2,2,2-trichloroethanol to the hy- drophobic core of a four-a-helix bundle protein 显示文摘 | Onas S Johansson K Solt K S | 2003 | Pho- tochemistry and Photobiology2003，77，1： | 1 |
| 5 | Chitinase levels in rice cultivars correlate with resistance to the sheath blight pathogen Rhizoctonia solani显示文摘 | SHRESTHA C L ONA I MUTHUKRISHNAN S | 2008 | European Journal of Plant Pathology2008，120，1： | 1 |
| 6 | Effects of sodium chloride on water potential components,hydraulic conductivity,gas exchange and leaf ultrastructure of Arbutus unedo plants显示文摘 | Navarro A Ba(n)ona S Olmos E | | 0，，03： | 1 |
| 7 | Hypertension in transgenic mice with brain-selective overexpression of the alpha (2B)-adrenoceptor显示文摘 | Kintsurashvili E Shenouda S Ona D | 2009 | Am J Hypertens2009，22，1： | 1 |
| 8 | Foxp3^+ CD25^+ CD^+ natural regulatory T cells in dominant self-tolerance and autoimmunedisease显示文摘 | Sakaguchi S Ona M Setoguchi R | 2006 | Immunol Rev2006，212，： | 1 |
| 9 | Partial inhibition of integrin alpha (v) beta6 prevents pulmonary fibrosis without exacerbating inflam- mation 显示文摘 | Horan GS Wood S Ona V | 2008 | Am J Respir Crit Care Med2008，177，： | 1 |
| 10 | Partial inhibition of integrin alpha (v) beta6 prevents pulmonary fibrosis without exacerbating inflam- mation 显示文摘 | Horan GS Wood S Ona V | 2005 | Am J Respir Crit Care Med2005，177，1： | 1 |
| 11 | Total oxidation of volatile organic compounds by vanadium promoted palladium-titania catalysts:Comparison of aromatic and polyaromatic compounds显示文摘 | Garcia T Sol(s)ona B Cazorla-Amoros D | | 0，，： | 1 |
| 12 | Minocycline inhibits cytochrome C release and delays progression of amyotrophic lateral sclerosis in mice显示文摘 | Zhu S Stavrovskaya IG Drozda M Kim BY Ona V Li M | 2002 | Nature2002，417，6884： | 1 |
| 13 | A systematic review of FDG-PET in breast cancer显示文摘 | Esca|ona S Blasco JA Reza MM | 2010 | Med Oncol2010，27，1： | 1 |
| 14 | Craniofacial develop- ment in children with unilateral cleft lip and palate 显示文摘 | Dogan S Ona G Akin Y | 2006 | Br J Oral Maxillofac Surg2006，44，1： | 1 |
| 15 | Enhanced resistance to sheath blight by constitutive expression of infection related rice chitinase in transgenic elite indica rice cultivars显示文摘 | DATTA K TU J OLIVA N ONA I VELAZHAHAN R MEW T W MUTHUKRISHNAN S DATTA S K | 2001 | Plant Science2001，160，3： | 1 |
| 16 | Partial inhibition of integrin al- pha(v) beta6 prevents pulmonary fibrosis without exacerbating in- flammation显示文摘 | HORAN GS WOOD S ONA | 2008 | Am J Respir Cri Care Med2008，177，1： | 1 |
| 17 | Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice显示文摘 | Zhu S Stavrovskaya IG Drozda M Kim BY Ona V Li M | 2002 | Nature2002，417，6884： | 1 |
| 18 | Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease显示文摘 | Chen M Ona VO Li M Ferrante RJ Fink KB Zhu S | 2000 | Nat Med2000，6，10： | 1 |
| 19 | Antioxidative activity of 5,6,7,8-tetrahydrobiopterin and its inhibitory effect on paraquat-induced cell toxicity in cultured rat hepatocytes显示文摘 | Kojima S Ona S Iizuka I Arai T Mori H Kubota K | 1995 | Free Radic Res1995，23，： | 1 |
| 20 | Impact of innova- tive practices in environmentally focused firms: Mode- rating factors显示文摘 | Ona S Signes P Garrigos A | 2011 | International Journal of Environmental Research2011，5，2： | 1 |
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