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| 1 | Regulation of RIG-I-like receptor-mediated signaling:interaction between host and viral factors显示文摘Retinoic acid-inducible gene I(RIG-l)-like receptors(RLRs)are RNA sensor molecules that play essential roles in innate antiviral immunity.Among the three RLRs encoded by the human genome,RIG-1 and melanoma differentiation-associated gene 5,which contain N-terminal caspase recruitment domains,are activated upon the detection of viral RNAs in the cytoplasm of virus-infected cells.Activated RLRs induce downstream signaling via their interactions with mitochondrial antiviral signaling proteins and activate the production of type Ⅰ and Ⅲ interferons and inflammatory cytokines.Recent studies have shown that RLR-mediated signaling is regulated by interactions with endogenous RNAs and host proteins,such as those involved in stress responses and posttranslational modifications.Since RLR-mediated cytokine production is also involved in the regulation of acquired immunity,the deregulation of RLR-mediated signaling is associated with autoimmune and autoinflammatory disorders.Moreover,RLRmediated signaling might be involved in the aberrant cytokine production observed in coronavirus disease 2019.Since the discovery of RLRs in 2004,significant progress has been made in understanding the mechanisms underlying the activation and regulation of RLR-mediated signaling pathways.Here,we review the recent advances in the understanding of regulated RNA recognition and signal activation by RLRs,focusing on the interactions between various host and viral factors. | Koji Onomoto Kazuhide Onoguchi Mitsutoshi Yoneyama | 2021 | Cellular & Molecular Immunology2021，18，3： | 8 |
| 2 | Viral infections activate type Ⅰ and Ⅲ interferon genes through a common mechanism显示文摘 | Onoguchi K Yoneyama M Takemura A | 2007 | J Biol Chem2007，282，10： | 1 |
| 3 | Viral infections activate types I and III interferon genes through a common mechanism显示文摘 | Onoguchi K Yoneyama M Takemura A | 2007 | J Biol Chem2007，282，10： | 1 |
| 4 | Viral infections activate types I and III interferon genes through a common mechanism显示文摘 | Onoguchi K Yoneyama M Takemura A | 2007 | J Biol Chem2007，282，10： | 1 |
| 5 | A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development显示文摘 | Onoguchi M Hirabayashi Y Koseki H | 2012 | Proc Natl Acad Sci U S A2012，109，16： | 1 |
| 6 | Viral infections activate types I and III interferon genes through a common mecha- nism 显示文摘 | Onoguchi K Yoneyama M Takemura A | 2007 | J Biol Chem2007，282，10： | 1 |
| 7 | Type I interferon pro-duction induced by RIG- I -like receptors显示文摘 | OnomotoK Onoguchi K Takahasi K | 2010 | J Interferon CytokineRes2010，30，12： | 1 |
| 8 | Viralinfections activate types Ⅰ and Ⅲ interferon genes througha common mechanism显示文摘 | Onoguchi K Yoneyama M Takemura A | 2007 | J Biol Chem2007，282，10： | 1 |
| 9 | Beneficial effect of balloon-induced pulsatility on brain oxygenation in hypothemic cardiopulmonarybypass显示文摘 | Hashimoto K Onoguchi K Takakura H | 2001 | J Cardiovasc Surg(Torino)2001，42，5： | 1 |
| 10 | Novel method for quantitative evaluation of cardiac amyloidosis using 201 TICI and 99mTc_PYP SPECT显示文摘 | Yamamoto Y Onoguchi M Haramoto M | 2012 | Ann Nucl Med2012，26，8： | 1 |
| 11 | Viral infections activate types Ⅰ and Ⅲ interferon genes through a common mechanism显示文摘 | Onoguchi K Yoneyama M Takemura A | | 0，，10： | 1 |
| 12 | Triggering antiviral re-sponse by RIG-I-related RNA helicases显示文摘 | Fujita T Onoguchi K Onomoto K | 2007 | Biochimie2007，89，67： | 1 |
| 13 | Viral infections activate types Ⅰ and Ⅲ interferon genes through a common mechanism显示文摘 | Onoguchi K Yoneyama M Takemura A | 2007 | J Biol Chem2007，282，10： | 1 |
| 14 | Viral Infections Activate Types Ⅰ and Ⅲ Interferon Genes through a Common Mechanism显示文摘 | Kazuhide Onoguchi Mitsutoshi Yoneyama Azumi Takemura | 2007 | J Biol Chem2007，282，10： | 1 |
| 15 | Virus- infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1 显示文摘 | Onoguchi K Onomoto K Takamatsu S | 2010 | PLoS Pathogens2010，6，10： | 1 |
| 16 | Viral infections acti-vate types I and HI interferon genes through a common mechanism显示文摘 | Onoguchi K Yoneyama M Takemura A | 2007 | J Biol Chem2007，282，10： | 1 |
| 17 | 心肌模型和分析软件的研发及其在心肌SPECT显像标准化中作用的多中心研究显示文摘目的该课题组自主研发了一款心肌模型和分析软件,通过标准化的定量指标来客观评价显像质量。研究目的是明确该模型和软件是否适用于显像的标准化。方法为对心肌SPECT显像进行标准化,课题组研发了心肌显像的评价分析软件(EMIT)和模型,利用该模型对胸部进行模拟,其内设置了肺和心脏。心肌模型包括5个放射性正常区域和8个放射性缺损区域。 | 唐军 Takayuki Shibutani Masahisa Onoguchi Tetsuro Katafuchi Seigo Kinuya | 2017 | 中华核医学与分子影像杂志2017，37，8： | 0 |
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