|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A numerical study of summer ozone concentration over the Kanto area of Japan using the MM5/CMAQ model显示文摘We assessed the ability of the MM5/CMAQ model to predict ozone (O 3) air quality over the Kanto area and to investigate the factors that affect simulation of O 3.We find that the coupled MM5/CMAQ model is a useful tool for the analysis of urban environmental problems.The simulation results were compared with observational data and were found to accurately replicate most of the important observed characteristics.The initial and boundary conditions were found to have a significant effect on simulated O3 concentrations.The results show that on hot and dry days with high O3 concentration,the CMAQ model provides a poor simulation of O3 maxima when using initial and boundary conditions derived from the CMAQ default data.The simulation of peak O3 concentrations is improved with the JCAP initial and boundary conditions.On mild days,the default CMAQ initial and boundary conditions provide a more realistic simulation.Meteorological conditions also have a strong impact on the simulated distribution and accumulation of O3 concentrations in this area.Low O3 concentrations are simulated during mild weather conditions,and high concentrations are predicted during hot and dry weather.By investigating the effects of different meteorological conditions on each model process,we find that advection and diffusion differ the most between the two meteorological regimes.Thus,differences in the winds that govern the transport of O3 and its precursors are likely the most important meteorological drivers of ozone concentration over the central Kanto area. | Mai Khiem Ryozo Ooka Hong Huang Hiroshi Hayami | 2011 | Journal of Environmental Sciences2011，23，2： | 12 |
| 2 | Epstein-Barr病毒BARF1基因协同TPA诱发猴肾上皮细胞恶性转化的研究显示文摘目的 探讨Epstein Barr病毒 (EBV)BARF1基因单独或协同佛波醇乙酯 (TPA)诱发猴肾上皮细胞恶性转化的作用。方法 用猴肾永生化上皮细胞PT1和PT7单独或进一步加促癌物TPA注射裸鼠或Scid小鼠背部皮下 ,观察成瘤情况。结果 EB病毒BARF1永生化细胞PT1和PT7在裸鼠不能形成肿瘤 ,但在免疫力严重缺陷的Scid小鼠能形成肿瘤 ,成瘤率为 6 6 7%~ 10 0 % ,成瘤时间较长为45~ 6 0d。加TPA后裸鼠及Scid小鼠均能形成肿瘤 ,裸鼠的成瘤时间为 2 0~ 2 2d ,Scid小鼠的成瘤时间为 5~ 7d。用聚合酶链反应 (PCR)可从肿瘤组织中扩增出BARF1基因。结论 EB病毒BARF1基因是致癌基因 ,甚至无需促癌物等辅助条件 。 | 郭秀婵 盛望 张永利 黄燕萍 T Ooka 曾毅 | 2001 | 中华实验和临床病毒学杂志2001，15，4： | 7 |
| 3 | Is ERCP really necessary in case of suspected spontaneous passage of bile duct stones?显示文摘AIM:To investigate the usefulness of magnetic resonance cholangiopancreatography (MRCP) and the need for endoscopic retrograde cholangiopancreatography (ERCP) in cases of suspected spontaneous passage of stones into the common bile duct.METHODS:Thirty-six patients with gallbladder stones were clinically suspected of spontaneous passage of stones into the common bile duct because they presented with clinical symptoms such as abdominal pain and fever,and showed signs of inflammatory reaction and marked rise of hepatobiliary enzymes.These symptoms resolved and they showed normalized values of blood biochemical parameters after conservative treatment without evidence of stones in the common bile duct on MRCP.All these patients were subjected to ERCP within 3 d of MRCP to check for the presence of stones.RESULTS:No stones were detected by ERCP in any patient,confi rming the results of MRCP.CONCLUSION:When clinical symptoms improve,blood biochemical parameters have normalized,and MRCP shows there are no stones in the common bile duct,it can be considered the stone has spontaneously passed and thus ERCP is not necessary. | Yuji Sakai Toshio Tsuyuguchi Takeshi Ishihara Seigo Yukisawa Tadashi Ohara Masaru Tsuboi Yoshihiko Ooka Kazuki Kato Kiyotake Katsuura Michio Kimura Makoto Takahashi Kazuhisa Nemoto Masaru Miyazaki Osamu Yokosuka | 2009 | World Journal of Gastroenterology2009，15，26： | 6 |
| 4 | Clinical usefulness of endoscopic ultrasonography for the evaluation of ulcerative colitis-associated tumors显示文摘AIM:To evaluate the clinical usefulness of endoscopic ultrasonography(EUS) for the diagnosis of the invasion depth of ulcerative colitis-associated tumors.METHODS:The study group comprised 13 patients with 16 ulcerative colitis(UC)-associated tumors for which the depth of invasion was preoperatively estimated by EUS.The lesions were then resected endoscopically or by surgical colectomy and were examined histopathologically.The mean age of the subjects was 48.2 ± 17.1 years,and the mean duration of UC was 15.8 ± 8.3 years.Two lesions were treated by endoscopic resection and the other 14 lesions by surgical colectomy.The depth of invasion of UCassociated tumors was estimated by EUS using an ultrasonic probe and was evaluated on the basis of the deepest layer with narrowing or rupture of the colonic wall.RESULTS:The diagnosis of UC-associated tumors by EUS was carcinoma for 13 lesions and dysplasia for 3 lesions.The invasion depth of the carcinomas was intramucosal for 8 lesions,submucosal for 2,the muscularis propria for 2,and subserosal for 1.Eleven(69%) of the 16 lesions arose in the rectum.The macroscopic appearance was the laterally spreading tumor-non-granular type for 4 lesions,sessile type for 4,laterally spreading tumor-granular type for 3,semipedunculated type(Isp) for 2,type 1 for 2,and type 3 for 1.The depth of invasion was correctly estimated by EUS for 15 lesions(94%) but was misdiagnosed as intramucosal for 1 carcinoma with high-grade submucosal invasion.The 2 lesions treated by endoscopic resection were intramucosal carcinoma and dysplasia,and both were diagnosed as intramucosal lesions by EUS.CONCLUSION:EUS provides a good estimation of the invasion depth of UC-associated tumors and may thus facilitate the selection of treatment. | Kiyonori Kobayashi Kana Kawagishi Shouhei Ooka Kaoru Yokoyama Miwa Sada Wasaburo Koizumi | 2015 | World Journal of Gastroenterology2015，21，9： | 5 |
| 5 | Biological features and biomarkers in hepatocellular carcinoma显示文摘Similar to other cancers, a multistep process of carcinogenesis is observed in hepatocellular carcinoma(HCC). Although the mechanisms underlying the development of HCC have been investigated in terms of oncology, virology, and stem cell biology, the whole picture of hepatocarcinogenesis remains to be elucidated. Recent progress in molecular biology has provided clues to the underlying cause of various diseases. In particular, sequencing technologies, such as whole genome and exome sequencing analyses, have made an impact on genomic research on a variety of cancers including HCC. Comprehensive genomic analyses have detected numerous abnormal genetic alterations, such as mutations and copy number alterations. Based on these findings, signaling pathways and cancer-related genes involved in hepatocarcinogenesis could be analyzed in detail. Simultaneously, a number of novel biomarkers, both from tissue and blood samples, have been recently reported. These biomarkers have been successfully applied to early diagnosis and prognostic prediction of patients with HCC. In this review, we focus on the recent developments in molecular cancer research on HCC and explain the biological features and novel biomarkers. | Tetsuhiro Chiba Eiichiro Suzuki Tomoko Saito Sadahisa Ogasawara Yoshihiko Ooka Akinobu Tawada Atsushi Iwama Osamu Yokosuka | 2015 | World Journal of Hepatology2015，7，16： | 5 |
| 6 | Genome-wide analysis of NAC transcription factor family in rice显示文摘 | Mohammed Nuruzzaman Ramaswamy Manimekalai Akhter Most Sharoni Kouji Satoh Hiroaki Kondoh Hisako Ooka Shoshi Kikuchi | 2010 | Gene2010，，1： | 5 |
| 7 | Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats显示文摘 | K.B.M. Saiful Islam Satoru Fukiya Masahito Hagio Nobuyuki Fujii Satoshi Ishizuka Tadasuke Ooka Yoshitoshi Ogura Tetsuya Hayashi Atsushi Yokota | 2011 | Gastroenterology2011，，5： | 2 |
| 8 | TccP2-mediated subversion of actin dynamics by EPEC 2 - a distinct evolutionarylineage of enteropathogenic Escherichia coli 显示文摘 | Whale AD Hernandes RT Ooka T | 2007 | Microbiology2007，153，： | 1 |
| 9 | Surface-enhanced Raman spectroscopy of DOPA-eontaining peptides related to adhesive protein of marine mussel Mytilus edulis 显示文摘 | Akemi Ooka A Garrell R L | 2000 | Biopolymers2000，57，2： | 1 |
| 10 | Adsorptive and photocatalytic performance of TiO2 pillared montmorillonite in degradation of endocrine disruptors having different hydrophobicity显示文摘 | Ooka C Yoshida H Horio M | 2003 | Applied Catalysis B:Environmental2003，41，3： | 1 |
| 11 | CFD analysis of wind climate from human scale to urban scale 显示文摘 | Murakami S Ooka R Mochida A | 1999 | Journal of Wind Engineering and Industrial Acronymic1999，81，1： | 1 |
| 12 | A phase I/II study of S-1 with sorafenib in patients with advanced hepatocellular carcinoma显示文摘 | Ooka Y Chiba T Ogasawara S | 2014 | In- vest New Drugs2014，32，4： | 1 |
| 13 | Study on outdoor thermal environment of apartment block in Shenzhen, China with coupled simulation of convection, radiation and conduction 显示文摘 | Chen H Ooka R Harayama K | 2004 | Building and Environment2004，36，： | 1 |
| 14 | Bone marrow micrometastases detected by RT-PCR for mammaglobin can be an alternative prognostic factor of breast cancer显示文摘 | Ooka M Tamaki Y Sakita I | 2001 | Breast Cancer Res Treat2001，67，2： | 1 |
| 15 | Crystallization of hydrothermally treated TiO2 pillars in pillared montmorillonite for improvement of the photocatalytic activity显示文摘 | Ooka C Akita S Ohashi Y | 1999 | Journal of Materials Chemistry1999，9，11： | 1 |
| 16 | Transcatheter arterial infusion for advanced hepatocellular carcinoma: Who are candidates?显示文摘AIM: To elucidate anticancer effects of transcatheter arterial infusion chemotherapy(TAI) in patients with hepatocellular carcinoma(HCC). METHODS: Data from a total of 95 patients with HCC who received TAI were analyzed retrospectively. The efficacy of TAI was evaluated according to the Response Evaluation Criteria in Cancer of the Liver. Overall survival was calculated from the date of initial treatment to the date of death or last follow-up. Survival curves were calculated by the Kaplan-Meier method, and differences in survival were evaluated by the log rank test. Clinical variables that were identified as statistically different by a univariate analysis were included into the Cox proportional hazard regression model for multivariate analysis. A prognostic index based on the regression coefficients derived from variables identified by the multivariate analysis was constructed. Stratification of the patients was conducted using this prognostic index. RESULTS: The patient group was comprised of 76 men and 19 women with an average age of 68 years(range: 37-82 years). Six patients(6.3%) showedcomplete response and 18 patients(18.9%) showed partial response, for an overall response rate of 25.2%. The median overall survival was 27.6 mo, and the proportions of survivors at 1, 2, and 5 years were 67.4%, 54.0%, and 17.4%, respectively. Multivariate analysis demonstrated that no prior transcatheter arterial chemoembolization, lactate dehydrogenase < 230 IU/L, and performance status of 0 were the independent favorable prognostic factors. The development of a 0-3-point prognostic score index was based on the sum of these three prognostic factors. Subsequently, the patients were categorized into three groups: those with a good(prognostic index = 0-1; n = 54), intermediate(prognostic index = 2; n = 26), or poor(prognostic index = 3; n = 15) prognosis. The median survival times in these three groups were 41.0, 21.2, and 6.8 mo, respectively(P < 0.01). CONCLUSION: Our simple prognostic index may be helpful for management of patients in determining treatment strategies for advanced HCC in the era of molecularly targeted therapy. | Eiichiro Suzuki Tetsuhiro Chiba Yoshihiko Ooka Sadahisa Ogasawara Akinobu Tawada Tenyu Motoyama Naoya Kanogawa Tomoko Saito Masaharu Yoshikawa Osamu Yokosuka | 2015 | World Journal of Gastroenterology2015，21，29： | 1 |
| 17 | Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana 显示文摘 | Ooka H Satoh K Doi K | 2003 | DNA Res2003，10，6： | 1 |
| 18 | Characterization of tccP2 carried by atypical enteropathogenic Escherichia coli 显示文摘 | Ooka T Vieira MA Ogura Y | 2007 | FEMS Microbiol Lett2007，271，1： | 1 |
| 19 | Augmentation index is elevated in aortic aneurysm and dissection 显示文摘 | Shingu Y Shiiya N Ooka T | 2009 | Ann Thorac Surg2009，87，5： | 1 |
| 20 | Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana显示文摘 | OOKA H SATOH K DOI K NAGATA T OTOMO Y MURAKAMI K MATSUBARA K OSATO N KAWAI J CAMINCI P HAYASHIZAKI Y SUZUKI K KOJIMA K TAKAHARA Y YAMAMOTO K KIKUCHI S | 2003 | DNA Research2003，10，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员